Results 141 to 150 of about 4,845,209 (387)

A Novel Class of Multi‐substituted Diaryl Scaffold Derivatives Inhibit Glioblastoma Progression by Targeting CD155

Advanced Science, EarlyView.
Structural modification of clofoctol yielded a novel blood‐brain barrier‐permeable compound, B7, featuring a multi‐substituted diaryl scaffold. B7 demonstrates potent anti‐glioblastoma activity by suppressing glioblastoma stem cells proliferation, migration, and invasion through interactions with five key residues of poliovirus receptor cell adhesion ...
Yong‐jian Wang, Ting Sun, Si‐tu Xue, Zhong‐di Cai, Hong Yi, Miao Lv, Shi‐bo Kou, Rui Liu, Xiao‐zhong Peng, Zhuo‐rong Li   +9 more
wiley   +1 more source

Immediate results of combined and multivisceral resections for rectal cancer

Сибирский онкологический журнал, 2019
Background. Currently, the indications for multivisceral pelvic resections have increased dramatically. However, short-and long-term outcomes after these resections for locally advanced rectal cancer remain a subject of debate.The purpose of the study ...
S. G. Afanasyev, A. Yu. Dobrodeev, I. B. Khadagaev, S. A. Fursov, E. A. Usynin, А. S. Tarasova, D. A. Sorokin, V. V. Faltin, A. V. Usova   +8 more
doaj   +1 more source

Changing outcomes following pelvic exenteration for locally advanced and recurrent rectal cancer

BJS Open, 2019
Pelvic exenteration for locally advanced rectal cancer (LARC) and locally recurrent rectal cancer (LRRC) is technically challenging but increasingly performed in specialist centres. The aim of this study was to compare outcomes of exenteration over time.
M. E. A. G. J. N. Abdul M. W. A. K. K. R. M. G. B. K. Kelly Aalbers Aziz Abraham‐Nordling Alberda Antoni, M. Kelly, A. Aalbers, N. A. Aziz, M. Abraham-Nordling, W. Alberda, A. Antoniou, K. Austin, R. Baker, M. Bali, G. Baseckas, B. Bednarski, G. Beets, P. Berg, J. Beynon, S. Biondo, L. Bordeianou, M. Brunner, P. Buchwald, J. Burger, D. Burling, N. Campain, K. Chan, G. Chang, M. Chew, P. Chong, H. Christensen, M. Codd, A. Colquhoun, A. Corr, M. Coscia, P. Coyne, B. Creavin, L. Damjanović, I. Daniels, M. Davies, R. Davies, J. de Wilt, Q. Denost, C. Deutsch, D. Dietz, E. Dozois, M. Duff, T. Eglinton, M. Evans, M. Evans, N. Fearnhead, F. Frizelle, E. García-Granero, J. L. García-Sabrido, L. Gentilini, M. George, R. Glynn, T. Golda, B. Griffiths, J. Hagemans, D. Harji, D. Harris, A. Heriot, W. Hohenberger, T. Holm, J. Jenkins, Y. Kanemitsu, S. Kapur, D. Keller, S. Kelley, H. Kim, C. Koh, N. Kok, R. Kokelaar, C. Kontovounisios, M. Kusters, D. Larson, S. Laurberg, W. Law, P. Lee, M. Lydrup, A. Lynch, A. Martling, K. Mathis, W. Meijerink, A. Mentha, S. Merkel, F. McDermott, J. McGrath, A. Mihailo, A. Mirnezami, J. Morton, T. Mullaney, M. Nielsen, G. Nieuwenhuijzen, P. Nilsson, P. O'Connell, G. Palmer, D. Patsouras, G. Pellino, G. Poggioli, M. Quinn, A. Quyn, R. Radwan, S. Rasheed, P. Rasmussen, R. Rocha, J. Rothbarth, C. Roxburgh, H. Rutten, É. Ryan, P. Sagar, T. Sammour, A. Schizas, E. Schwarzkopf, V. Scripcariu, I. Shaikh, D. Shida, A. Simpson, N. Smart, J. Smith, M. Solomon, M. M. Sørensen, S. Steele, D. Steffens, L. Stocchi, N. Stylianides, C. Taylor, P. Tekkis, S. Tsukamoto, W. H. Turner, J. Tuynman, G. V. van Ramshorst, D. V. van Zoggel, W. Vasquez‐Jimenez, C. Verhoef, M. Verstegen, C. Wakeman, S. Warrier, H. Wasmuth, M. Weiser, J. Wheeler, J. Wild, D. Winter, J. Yip   +140 more
semanticscholar   +1 more source

Patients‐Derived Organoids Sequencing‐based FOXP4 Facilitates Radioresistance by Transcriptionally Modifying GPX4 to Regulate ferroptosis in Colorectal Cancer

Advanced Science, EarlyView.
FOXP4 regulates GPX4 transcription to suppress ferroptosis. In CRC patients, initial biopsies established PDO cultures alongside concurrent chemoradiotherapy. Post‐treatment MRI with mrTRG scoring stratified radioresistant/sensitive cohorts. Parallelly, 8Gy‐irradiated PDOs underwent viability‐based stratification.
Qianping Chen, Yuzhao Jin, Luyu Liao, Rong Shen, Xingnan Ge, Qingyu Jiang, Ying Huang, Quanquan Sun, Dong Liu, Luying Liu, Tongxin Liu, Qinghui Dai, Xiyuan Tang, Zhe Han, Xin Gao, Xinhua Lin, Wei Mao, Ji Zhu   +17 more
wiley   +1 more source

Rectal Injuries Following the Stockholm Method of Treatment of Cancer of the Cervix Uteri [PDF]

, 1947
Axel Ingelman‐Sundberg
openalex   +1 more source

Cancer Cell‐Derived Large Extracellular Vesicles Promote Venous Thromboembolism by Activating NETosis Through Delivering CYBA

Advanced Science, EarlyView.
Venous thromboembolism (VTE) is a major threat to cancer patients. Cancer‐derived large extracellular vesicles deliver CYBA (p22phox) to neutrophils, triggering reactive oxygen species (ROS) and citrullinated histone H3 (citH3) formation. This drives neutrophil extracellular traps formation (NETosis), elevating VTE risk.
Xiangji Li, Yingjiao Ju, Chenjie Xu, Shixiang Ma, Lan Sun, Qingdong Guo, Mingyuan Liu, Yibin Xie, Li Min   +8 more
wiley   +1 more source

European guidelines from the EHTG and ESCP for Lynch syndrome: an updated third edition of the Mallorca guidelines based on gene and gender

BJS (British Journal of Surgery), EarlyView., 2020
Recommendations for clinical and molecular identification of LS, surgical and endoscopic management of LS‐associated colorectal cancer and preventive measures for cancer were produced. The emphasis was on surgical and gastroenterological aspects of the cancer spectrum.
T. T. Seppälä, A. Latchford, I. Negoi, A. Sampaio Soares, R. Jimenez‐Rodriguez, L. Sánchez‐Guillén, D. G. Evans, N. Ryan, E. J. Crosbie, M. Dominguez‐Valentin, J. Burn, M. Kloor, M. von Knebel Doeberitz, F. J. B. van Duijnhoven, P. Quirke, J. R. Sampson, P. Møller, G. Möslein, on behalf of the European Hereditary Tumour Group (EHTG) and European Society of Coloproctology (ESCP)   +18 more
wiley   +1 more source

II. Pregnancy and Labour Complicated by Rectal Cancer. [PDF]

, 1908
J Kynoch
openalex   +1 more source

Tumour invasiveness, the local and systemic environment and the basis of staging systems in colorectal cancer [PDF]

, 2017
background: The present study aimed to examine the relationship between tumour invasiveness (T stage), the local and systemic environment and cancer-specific survival (CSS) of patients with primary operable colorectal cancer.
A Chrysanthopoulou, A Huijbers, AJ Munro, B Mlecnik, C Guastadisegni, C S D Roxburgh, CE Dukes, CH Richards, D C McMillan, D Church, D Hanahan, DC McMillan, F Pages, F Pages, FA Sinicrope, G Bindea, GJ Guthrie, H Ueno, H Ueno, H van Wyk, HC van Wyk, ID Nagtegaal, J Edwards, J Galon, J Guinney, J H Park, J Li, JB O'Connell, JH Park, JH Park, JH Park, JH Park, K Birkenkamp-Demtroder, K Klintrup, L De Smedt, LL Gunderson, LS Rozek, MJ Pollheimer, P G Horgan, P Quirke, R Salazar, S Ogino, SA Vayrynen, SS McAllister, T Kantola, VH Koelzer, W De Roock, WE Mesker   +47 more
core   +1 more source

A Charge‐Adhesive Targeted DNA Gel Bandage for the Precision Treatment of Inflammatory Bowel Disease

Advanced Science, EarlyView.
DNA gel bandage (DNAgb) is designed to precisely target the site of inflammation of IBD, by achieving dual specific localization of inflamed mucosa through electrostatic interactions and ApITGA4‐mediated affinity targeting. DNAgb effectively the activation of inflammatory pathways and reshapes the immune microenvironment.
Peifen Lu, Hongxiu Yuan, Gang Wang, Tao Cheng, Lie Li, Yixi Dong, Runyu Zhao, Xuerui Zhang, Jianwei Jiao, Jin Jiao   +9 more
wiley   +1 more source