Results 131 to 140 of about 551,144 (359)

MRI‐Derived Lymph Nodes Morphological and Topological Structure (LNs‐MTS) Model for Evaluating Immune Status and Prognosis in Rectal Cancer

Advanced Science, EarlyView.
An MRI‐derived Lymph Nodes morphological and topological structure (LNs‐MTS) model is established to evaluate the immune status of the lymph node system in rectal cancer. It provides a non‐invasive, quantitative approach for prognosis assessment and optimizing adjuvant therapy decisions.
Yunxiao Liu, Liwen Zhang, Yanfen Cui, Weiyuan Zhang, Hanqing Hu, Shuai Jiao, Jian Ma, Jiale Li, Jun Xiang, Jinna Li, Haiyi Liu, Xiaotang Yang, Jie Tian, Xishan Wang, Guiyu Wang, Xu Guan   +15 more
wiley   +1 more source

Neuroendocrine Rectal Tumors: Main Features and Management

GE: Portuguese Journal of Gastroenterology, 2015
The incidence of neuroendocrine tumors of the rectum has been increasing in the last decades, partly due to improved investigation. They are mostly well-differentiated small tumors with a rather good overall prognosis. In the last few years, some aspects
Ângela Rodrigues, Fernando Castro-Poças, Isabel Pedroto   +2 more
doaj   +1 more source

Socioeconomic Indicators, Tobacco and Alcohol in the Aetiology of Digestive Tract Neoplasms [PDF]

, 2017
Ferraroni M {Institute of Medical Statistics, University of Milan, 20133 Milan, Italy), Negri E, La Vecchia C, D'Avanzo B and Franceschi S. Socioeconomic indicators, tobacco and alcohol in the aetiology of digestive tract neoplasms. International Journal
D'AVANZO, BARBARA, FERRARONI, MONICA, FRANCESCHI, SILVIA, NEGRI, EVA, VECCHIA, CARLO LA   +4 more
core  

Akkermansia muciniphila‐Derived N‐Acetylspermidine Modulates the Localization of Intestinal α1,2‐Fucosylated Proteins to Maintain Gut Homeostasis

Advanced Science, EarlyView.
This study demonstrates that Akkermansia muciniphila alleviates colitis by enhancing intestinal α1,2‐fucosylation through its metabolite N‐acetylspermidine. Mechanistically, N‐acetylspermidine‐induced PIM1 inhibition promotes HDAC2‐mediated reduction of chromatin accessibility at TP73, thereby upregulating C1GALT1C1 to boost α1,2‐fucosylation.
Ye Yao, Zhangming Pei, Yuanyuan Dai, Yinghan Chen, Zepeng Chang, Hongchao Wang, Jianxin Zhao, Hao Zhang, Qixiao Zhai, Wenwei Lu, Wei Chen   +10 more
wiley   +1 more source

The role of endoscopic ultrasonography in the management of cystic lesions of the pancreas [PDF]

, 2003
Objective. To review the role of endoscopic ultrasonography in the management of cystic lesions of the pancreas. Data sources. MEDLINE literature search (1998-2003). Study selection. Key words for the literature search were 'endoscopic ultrasonography', '
Chan, ACY, Liu, CL
core  

KLK1 as an Epithelial‐Specific Brake Inhibits Colorectal Tumorigenesis by Suppressing B1R‐Mediated Fibroblast Phenotypic Transition

Advanced Science, EarlyView.
KLK1 downregulation disrupts the intestinal mucosal barrier and impairs kallikrein‐kinin signaling, thereby reducing Lys‐des‐Arg9‐BK production. This enhances B1R activation on ADAMDEC1⁺ fibroblasts, promoting inflammation and extracellular matrix (ECM) remodeling. The resulting iCAFs promote colorectal cancer progression, highlighting a novel KLK1‐B1R
Lisha Zhou, Meijing Wang, Shunji Liu, Limei Gu, Shijia Liu, Qianming Du, Tianyi Zhang, Yinuo Ma, Lixin Zhao, Jiaming Wang, Qiang Xu, Tingsheng Ling, Haibo Cheng, Hongqi Chen, Yang Sun   +14 more
wiley   +1 more source

Enhancing prognostic accuracy in predicting rectal neuroendocrine neoplasms

World Journal of Gastroenterology
The recently published retrospective study introduces the GATIS score, a new predictive model for rectal neuroendocrine neoplasms. By analyzing data from a large Chinese multicenter cohort, the study shows that the GATIS score, incorporating tumor grade, T stage, tumor size, age, and prognostic nutritional index, demonstrates superior predictive power ...
Raj, Renin Peter AA, Nashwan, Abdulqadir J   +1 more
openaire   +2 more sources

Patients‐Derived Organoids Sequencing‐based FOXP4 Facilitates Radioresistance by Transcriptionally Modifying GPX4 to Regulate ferroptosis in Colorectal Cancer

Advanced Science, EarlyView.
FOXP4 regulates GPX4 transcription to suppress ferroptosis. In CRC patients, initial biopsies established PDO cultures alongside concurrent chemoradiotherapy. Post‐treatment MRI with mrTRG scoring stratified radioresistant/sensitive cohorts. Parallelly, 8Gy‐irradiated PDOs underwent viability‐based stratification.
Qianping Chen, Yuzhao Jin, Luyu Liao, Rong Shen, Xingnan Ge, Qingyu Jiang, Ying Huang, Quanquan Sun, Dong Liu, Luying Liu, Tongxin Liu, Qinghui Dai, Xiyuan Tang, Zhe Han, Xin Gao, Xinhua Lin, Wei Mao, Ji Zhu   +17 more
wiley   +1 more source

Outcomes and Learning Curve in Endoscopic Submucosal Dissection of Rectal Neoplasms with Severe Fibrosis: Experience of a Western Center. [PDF]

GE Port J Gastroenterol, 2023
Félix C, Barreiro P, Mendo R, Mascarenhas A, Chagas C.   +4 more
europepmc   +1 more source

Cancer Cell‐Derived Large Extracellular Vesicles Promote Venous Thromboembolism by Activating NETosis Through Delivering CYBA

Advanced Science, EarlyView.
Venous thromboembolism (VTE) is a major threat to cancer patients. Cancer‐derived large extracellular vesicles deliver CYBA (p22phox) to neutrophils, triggering reactive oxygen species (ROS) and citrullinated histone H3 (citH3) formation. This drives neutrophil extracellular traps formation (NETosis), elevating VTE risk.
Xiangji Li, Yingjiao Ju, Chenjie Xu, Shixiang Ma, Lan Sun, Qingdong Guo, Mingyuan Liu, Yibin Xie, Li Min   +8 more
wiley   +1 more source