Results 131 to 140 of about 88,736 (267)

Oxaliplatin‐induced neuropathy after total neoadjuvant therapy for rectal cancer: Dose–response relationship and impact on quality of life

International Journal of Cancer, EarlyView.
What's New? Oxaliplatin serves a key role in the treatment of rectal cancer, though it is a significant cause of chemotherapy‐induced peripheral neuropathy. As total neoadjuvant therapy, in which all therapy is given before surgery, has become more common, understanding neuropathy has grown increasingly important. This study examined neuropathy and its
Georg W. Wurschi, Andreas Hinz, Melanie Schneider, Jan‐Niklas Becker, Bernd Frerker, Samuel M. Vorbach, Felix Ehret, Markus Diefenhardt, Fabian Schunn, Maria‐Elena von Gruben, Marcel Büttner, Elgin Hoffmann, Alexander Rühle, Josephine Beier, Simone Ferdinandus, Maike Trommer, Ezgi Ceren Sahin, Julian Hlouschek, Kynann Aninditha, Daphne Schepers von Ohlen, Justus Kaufmann, Alina Depardon, Hai Minh Ha, Christopher Kessler, Adrianna Cieslak, Simon Trommer, Alexander Fabian, Florian Rißner, Maximilian Römer, Klaus Pietschmann   +29 more
wiley   +1 more source

Robot‐assisted resection of diaphragmatic and hepatorenal recess peritoneal endometriosis: Two cases and a narrative review

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract In this report, we describe two cases of diaphragmatic endometriosis with concurrent hepatorenal recess peritoneal involvement managed using robotic‐assisted laparoscopic surgery with the da Vinci Xi platform. In both patients, diaphragmatic implants and hepatorenal recess peritoneal lesions were excised en bloc, followed by resection of ...
Xiaoming Guan, Qiannan Yang, Daniel Y. Lovell, Chunhua Zhang   +3 more
wiley   +1 more source

Inhibition of ferroptosis by microbiota‐derived lithocholic acid underlies the intestinal radioprotection of a host defensin‐derived oligopeptide

iMeta, EarlyView.
AT9(C/G), an oligopeptide derived from human defensin 5, enriches Bifidobacterium pseudolongum and increases lithocholic acid (LCA) levels in the intestine. Reduced levels of LCA link to increased severity of ionizing radiation‐induced intestinal injury (IRIII) in both murine and clinical studies.
Xue Ouyang, Yingjuan He, Zihao Jin, Shaobo Wang, Gaomei Zhao, Xiaona Su, Jia Du, Yin Chen, Chengzhang Tan, Xin Li, Songling Han, Bin Wang, Jinghong Zhao, Jianqin Niu, Chuan Chen, Junping Wang, Cheng Wang   +16 more
wiley   +1 more source

Microbial metabolites in tumor epigenetic regulation

iMeta, EarlyView.
The gut microbiome modulates tumor epigenetic regulation through bioactive metabolites derived from dietary substrates. Microbiota‐produced SCFAs, secondary BAs, one‐carbon metabolites, and tryptophan‐derived ligands regulate histone acetylation, DNA methylation, and chromatin remodeling via HDAC, DNMT, AhR, and metabolic cofactor‐dependent pathways ...
Wangzheqi Zhang, Haoling Zhang, Yan Liao, Shuya Jiang, Haolong Zhang, Chenwei Huang, Zhijing Song, Rui Zhao, Ping Lu, Xiaohong Kang, Eryan Kong, Yalin Zhu, Wei Wang, Xuesong Liu, Yisheng Chen, Zhiwen Luo, Zhaoyu Li, Di Wang, Na Xing, Yadong Guo, Jingjing Zhang, Xiaojing Wang, Wenyi Wang, Mowaffaq Adam, Bakiah Shaharuddin, Muhamad Yusri Musa, Doblin Sandai, Chenglong Zhu, Aimin Jiang, Peng Luo, Zhijie Zhao, Zui Zou   +31 more
wiley   +1 more source

Targeting DGKα/PA axis inhibits tumor immune evasion and augments sensitivity to immunotherapy in gastrointestinal cancers

iMeta, EarlyView.
Immune checkpoint inhibitors (ICIs) have shown promising antitumor efficacy in certain types of solid tumors. However, the efficacy of ICIs remains unsatisfactory owing to the dysregulation of signaling pathways in local tumor tissues. Here, we reveal that diacylglycerol kinase α (DGKα)‐derived phosphatidic acid (PA) directly binds to nuclear factor‐κB
Jie Chen, Siqi Liu, Ting Peng, Fenglong Wang, Yuheng Zhu, Jingyuan Pang, Qingnan Wu, Yan Wang, Qimin Zhan   +8 more
wiley   +1 more source

Rectal PEComa Mimicking Gastrointestinal Stromal Tumor on Endoscopic Ultrasound. [PDF]

ACG Case Rep J
Zlatanic V, Gonda T, Young GQ, Wolfe S, Zlatanic J.   +4 more
europepmc   +1 more source

Hypervision Proton Surgery: The Future Direction of Proton Therapy

iNew Medicine, EarlyView.
ABSTRACT Proton beams provide unique physical advantages characterized by a low entrance dose, negligible exit dose, and a sharp Bragg peak, which enable superior sparing of normal tissues and support safe dose escalation for improved tumor control. However, conventional photon‐based fractionation remains widely used in proton therapy, where prolonged ...
Li Li, Shuanghu Yuan
wiley   +1 more source

Dual Tumor Pathogenesis in the Gastrointestinal Tract: Synchronous Rectal Schwannoma and Gallbladder Papillary Adenocarcinoma-A Case Report. [PDF]

Reports (MDPI)
Cotovanu A, Cosma CD, Molnar C, Gurzu S, Beleaua MA, Butiurca VO, Botoncea M.   +6 more
europepmc   +1 more source

Chinese pan‐cancer patient genomic characteristics: A comprehensive analysis based on the National Cancer Center–Clinical Diagnostics Knowledgebase real‐world clinical sequencing cohort

Interdisciplinary Medicine, EarlyView.
We assembled National Cancer Center–Clinical Diagnostics Knowledgebase, a clinical genomic knowledgebase of 6935 tumors with matched normal samples, revealing key somatic alterations and actionable variants (70.2% of the cohort). Enrichment of certain different gene mutations was observed between Chinese and American populations, along with a strong ...
Hongrui Li, Shun Wang, Guowei Zhao, Jiangtao Li, Xin Li, Bingning Wang, Yi Zhang, Mengfei Yao, Lei Guo, Jianming Ying, Wenbin Li   +10 more
wiley   +1 more source

Health-related quality of life scores of ultralow rectal cancer patients after conformal sphincter preservation operation compared to newly derived preoperative EORTC QLQ-C30, CR38 reference values and EORTC QLQ-C30 norm. [PDF]

Front Oncol
Ding HB, Sun G, Yu GY, Gao XH, Lou Z, Kuo Z, Gong HF, Zhu XM, Zhang W.   +8 more
europepmc   +1 more source