Results 141 to 150 of about 521,175 (343)

Intraoral Drug Delivery: Bridging the Gap Between Academic Research and Industrial Innovations

Advanced Functional Materials, EarlyView.
Intraoral drug delivery offers a promising route for systemic and localized therapies, yet challenges such as enzymatic degradation, limited permeability, and microbial interactions hinder efficacy. This figure highlights innovative strategies—mucoadhesive materials, enzyme inhibitors, and permeation enhancers—to overcome these barriers.
Soheil Haddadzadegan, Simona Summonte, Fabrizio Ricci, Matthias Sandmeier, Andreas Bernkop‐Schnürch   +4 more
wiley   +1 more source

Caracterización de pacientes operados de cáncer colorrectal en el hospital “Guillermo Domínguez López”

Revista Electrónica Dr. Zoilo E. Marinello Vidaurreta, 2020
Fundamento: en el municipio Puerto Padre han ido aumentando paulatinamente los pacientes con el diagnóstico de cáncer de colon y recto.Objetivo: caracterizar a los pacientes operados de cáncer colorrectal en el servicio de cirugía del hospital “Guillermo
Jorge Luis Montes-de-Oca-Mastrapa, Adriana de la Caridad Cera-Gisbert   +1 more
doaj  

Neuroendocrine Cancer of Rectum Metastasizing to Ovary

Case Reports in Oncological Medicine, 2016
Neuroendocrine carcinomas (NECs) are rare malignancies that originate from the hormone-producing cells of the body’s neuroendocrine system. Rectal high grade NEC (HG-NEC) constituting less than 1% of colorectal cancers can cause large ovarian metastasis ...
Sapna Vinit Amin, Aswathy Kumaran, Sunanda Bharatnur, Akhila Vasudeva, Kartik Udupa, Dinesh Bangalore Venkateshiah, Shaila T. Bhat   +6 more
doaj   +1 more source

Transforming Healthcare: Intelligent Wearable Sensors Empowered by Smart Materials and Artificial Intelligence

Advanced Materials, EarlyView.
Wearable sensors, empowered by AI and smart materials, revolutionize healthcare by enabling intelligent disease diagnosis, personalized therapy, and seamless health monitoring without disrupting daily life. This review explores cutting‐edge advancements in smart materials and AI‐driven technologies that empower wearable sensors for diagnostics and ...
Shuwen Chen, Shicheng Fan, Zheng Qiao, Zixiong Wu, Baobao Lin, Zhijie Li, Michael A. Riegler, Matthew Yu Heng Wong, Arve Opheim, Olga Korostynska, Kaare Magne Nielsen, Thomas Glott, Anne Catrine T. Martinsen, Vibeke H. Telle‐Hansen, Chwee Teck Lim   +14 more
wiley   +1 more source

Effects of supplemental vitamin D and calcium on markers of proliferation, differentiation, and apoptosis in the normal colorectal mucosa of colorectal adenoma patients.

PLoS ONE, 2018
To clarify the roles of vitamin D and calcium as potential chemopreventive agents against colorectal cancer in humans, and to develop "treatable", pre-neoplastic, phenotypic biomarkers of risk for colorectal neoplasms, we estimated the effects of ...
Yasheen Gao, Caroline Y Um, Veronika Fedirko, Robin E Rutherford, March E Seabrook, Elizabeth L Barry, John A Baron, Roberd M Bostick   +7 more
doaj   +1 more source

On tumor development: fractional transport approach [PDF]

arXiv, 2004
A growth of malignant neoplasm is considered as a fractional transport approach. We suggested that the main process of the tumor development through a lymphatic net is fractional transport of cells. In the framework of this fractional kinetics we were able to show that the mean size of main growth is due to subdiffusion, while the appearance of ...
arxiv  

Bioprinted Patient‐Derived Organoid Arrays Capture Intrinsic and Extrinsic Tumor Features for Advanced Personalized Medicine

Advanced Science, EarlyView.
An embedded bioprinting enabled‐arrayed patient‐derived organoids (Eba‐PDO) platform that replicates intrinsic and extrinsic tumor characteristics is introduced. Eba‐PDOs more accurately mimic tissue than standard PDOs (Std‐PDOs) due to maturation in the tumor microenvironment.
Jonghyeuk Han, Hye‐Jin Jeong, Jeonghan Choi, Hyeonseo Kim, Taejoon Kwon, Kyungjae Myung, Kyemyung Park, Jung In Park, Samuel Sánchez, Deok‐Beom Jung, Chang Sik Yu, In Ho Song, Jin‐Hyung Shim, Seung‐Jae Myung, Hyun‐Wook Kang, Tae‐Eun Park   +15 more
wiley   +1 more source

A new era in surgical oncology: preliminary insights into the hinotori™ surgical robot system’s role in rectal surgery using the double bipolar method

World Journal of Surgical Oncology
Background The da Vinci™ Surgical System, recognized as the leading surgical robotic platform globally, now faces competition from a growing number of new robotic surgical systems.
Hidetoshi Katsuno, Koji Morohara, Tomoyoshi Endo, Yuko Chikaishi, Kenji Kikuchi, Kenichi Nakamura, Kazuhiro Matsuo, Takahiko Higashiguchi, Tetsuya Koide, Tsunekazu Hanai, Zenichi Morise   +10 more
doaj   +1 more source

TRIM38 Suppresses the Progression of Colorectal Cancer via Enhancing CCT6A Ubiquitination to Inhibit the MYC Pathway

Advanced Science, EarlyView.
This study reveals the tumor‐suppressive role of TRIM38 in colorectal cancer (CRC). TRIM38 is downregulated through DNA hypermethylation and correlates with unfavorable clinical features and poor prognosis. Mechanistically, TRIM38 inhibits CRC progression by promoting K48‐linked ubiquitination of CCT6A, leading to the destabilization of c‐Myc.
Yue Zhang, Xinyu Tan, Lu Wang, Dongjian Ji, Chuan Zhang, Wen Peng, Renzhong Zhu, Xiaowei Wang, Jiahui Zhou, Yifei Feng, Yueming Sun   +10 more
wiley   +1 more source

Functional Materials Targeted Regulation of Gasdermins: From Fundamentals to Functionalities and Applications

Advanced Science, EarlyView.
Targeted regulation of pyroptosis to modulate the immune landscape is a novel design strategy for cancer immunotherapy and anti‐inflammatory treatment. Pyroptosis, as a double‐edged sword, underscores the importance of optimizing the design strategy of functional materials and appropriately activating pyroptosis for the effective treatment of diseases.
Luyao Tian, Shuo Piao, Xia Li, Lanping Guo, Luqi Huang, Wenyuan Gao   +5 more
wiley   +1 more source