Results 81 to 90 of about 104,473 (343)

Microglial Fkbp5 Impairs Post‐Stroke Vascular Integrity and Regeneration by Promoting Yap1‐Mediated Glycolysis and Oxidative Phosphorylation

Advanced Science, EarlyView.
A post‐stroke perivascular niche of microglia characterized by low expression of M2 markers and elevated glycolysis, oxidative phosphorylation (OXPHOS), and phagocytic activity is identified, which is termed stroke‐activated vascular‐associated microglia (stroke‐VAM).
Yanan Li, Yanmei Qiu, Yunlei Yang, Yanhao Wei, Haokun Peng, Longhai Zeng, Pengcheng Li, Rentang Bi, Bo Hu   +8 more
wiley   +1 more source

Colorectal cancer screening: strategies to select populations with moderate risk for disease [PDF]

, 2015
Objective: to analyse the association between rectal bleeding or a family history of colorectal cancer (CRC) and the results obtained in two rounds of a CRC screening pilot programme performed in L'Hospitalet, Barcelona, Spain.
Binefa i Rodríguez, Gemma, Blanco Guillermo, Ignacio, Borràs Andrés, Josep Maria, Catalan Colorectal Cancer Screening Pilot Program Group, Espinàs Piñol, Josep Alfons, Guardiola, Jordi, Navarro, Matilde, Peris, Mercè   +7 more
core  

Habitual intake of flavonoid subclasses and risk of colorectal cancer in two large prospective cohorts [PDF]

, 2016
Background: Flavonoids inhibit the growth of colon cancer cells in vitro. In a secondary analysis of a randomized controlled trial, the Polyp Prevention Trial, a higher intake of one sub-class, flavonols, was significantly associated with reduced risk of
Aedín Cassidy, Andrew T Chan, Arts, Bobe, Cassidy, Cassidy, Charles S Fuchs, Colditz, Cutler, DerSimonian, Devore, Edward L Giovannucci, Eric B Rimm, Feskanich, Fini, Gao, Giovannucci, Hirvonen, Hu, Jennifer H Lin, Kana Wu, Kandaswami, Katharina Nimptsch, Knekt, Knekt, Kyle, Lambert, Lee, Lin, Mahmoud, McCullough, Mingyang Song, Moon, Mursu, Park, Platz, Rich-Edwards, Rimm, Rossi, Rossi, Sacks, Salvini, Shuji Ogino, Simons, Stampfer, Theodoratou, Tobias Pischon, Voorrips, Walter C Willett, Wei, Willett, Willett, Willett, Williamson, Williamson, Woo, Xuehong Zhang, Yamauchi, Yang, Yu, Yuan, Zamora-Ros, Éilis J O’Reilly   +62 more
core   +1 more source

NAD+‐Dependent Enzyme SIRT3 Limits Intestinal Epithelial Cell Functions Through NAD+ Synthesis Pathway in Colorectal Cancer

Advanced Science, EarlyView.
Microbiota‐derived quinolinic acid is used as an alternative source of replenishing the intracellular NAD+ pool induced by SIRT3 deficiency to regulate intestinal epithelial cell and T cell function, which has implications for targeting intestinal epithelial cells as an approach to the treatment of immune‐associated diseases, including colorectal ...
Ruiying Niu, Yingjie Dong, Jianghui Tong, Jingxuan Xia, Longhao Zhao, Zi Geng, Yingxin Lin, Jinghe Zhang, Xinyi Liu, Manqi Fang, Xi Jin, Yujing Bi, Guangwei Liu   +12 more
wiley   +1 more source

P53 mutations in human adrenocortical neoplasms [PDF]

, 1994
The mechanisms of tumorigenesis of adrenocortical neoplasms have not been elucidated as yet. However, loss of heterozygosity at chromosomal locus 17p has been consistently observed in adrenocortical cancer.
Allolio, B., Chrousos, G. P., Karl, M., Linehan, M., Mastorakis, G., Reincke, Martin, Travis, W.   +6 more
core  

Water enema computed tomography (WE-CT) in the local staging of low colorectal neoplasms: comparison with transrectal ultrasound [PDF]

, 1998
BACKGROUND: To determine the accuracy of computed tomography performed with a water enema application (WE-CT) in the local staging of low colorectal neoplasms and to compare the results with those of transrectal ultrasonography (TRUS).
Agostinho, A, Caseiro-Alves, F, Castro e Sousa, F, Gonçalo, Manuela, Ilharco, J, Vilaça-Ramos, H   +5 more
core   +1 more source

Early Detection of Cell Death Using Transmembrane Water Exchange Magnetic Resonance Imaging

Advanced Science, EarlyView.
Cell death is important in both the development and treatment of cancer. In this study, it is demonstrated for the first time that a specific measurement of the transmembrane water exchange rate using magnetic resonance imaging can be used as an early marker of cell death in mammalian cells, in animals and in human patients. Abstract Cell death plays a
Athanasia Kaika, Luca Nagel, Ulrike Höckendorf, Bangwen Xie, Geoffrey J. Topping, Mathias Schillmaier, Irina Beer, Frits H. A. van Heijster, Julian Rauch, Tristan A. Kuder, Sandra Sühnel, Bernd Erber, Christian Lohrmann, Simone Ballke, Thomas Metzler, Katja Steiger, Philipp J. Jost, Natalia P. Ivleva, Philipp Paprottka, Jonathan Nadjiri, Kevin M. Brindle, Wolfgang A. Weber, Franz Schilling   +22 more
wiley   +1 more source

Metastasis of Rectal Signet Ring Cell Carcinoma to Typical Lipoma: A Rare Presentation of the Tumor-to-Tumor Metastasis Phenomenon

Journal of Investigative Medicine High Impact Case Reports
Rectal signet ring cell carcinoma represents a rare subtype of colorectal adenocarcinoma known for its aggressive biological nature and poor prognosis. Although the co-occurrence of colorectal carcinoma with other tumors has been reported, the uncommon ...
Houyem Mansouri MD, Ines Zemni MD, Nedia Boujelbene MD, Fatma Saadallah MD, Mohamed Ali Ayadi MD, Leila Achouri MD   +5 more
doaj   +1 more source

The KDM6B/SLC10A2 Axis Suppresses MDSCs Recruitment via ERK/AP‐1 Signaling in Colorectal Cancer

Advanced Science, EarlyView.
In wild‐type intestinal epithelial cells, KDM6B demethylates SLC10A2 to promote its expression, after which SLC10A2 suppresses ERK phosphorylation, inhibiting AP‐1 (Fos/Jun) transcription and chemokine production. In KDM6B‐deficient intestinal epithelial cells, SLC10A2 methylation increases, and its expression decreases.
Zhibo Hu, Jing Xun, Bin Liu, Xiaolin Jiang, Yingdi Han, Huichao Yang, Qi Gao, Ruifang Gao, Aimin Zhang, Xueliang Wu, Dapeng Zhang, Dihua Li, Tian Li, Shimin Yang, Ximo Wang, Xiangyang Yu, Qi Zhang   +16 more
wiley   +1 more source

Large Friable Rectal Neuroendocrine Tumor Complicated by Hemorrhagic Shock: A Rare Case Report and Review of the Literature

JGH Open
Rectal neuroendocrine tumors (NETs) are rare neoplasms that are usually asymptomatic and diagnosed incidentally. There are limited data on the presentation and management of high‐grade poorly differentiated large friable rectal NETs.
Yazan Abboud, Imran Qureshi, Ayham Khrais, Alexander Le, Param Patel, Ozlem Fidan Ozbilgin, Sima Vossough‐Teehan   +6 more
doaj   +1 more source