Results 71 to 80 of about 165,545 (324)

Pre‐Administration of Akkermansia Muciniphila Prevents the Development of Severe Acute Graft‐Versus‐Host Disease in Systemic Organs

Advanced Science, EarlyView.
Akkermansia muciniphila, a next‐generation probiotic, alleviates acute graft‐versus‐host disease (aGvHD) following allogeneic hematopoietic stem cell transplantation (HSCT) by providing protective effects across multiple organs. Pre‐colonization with A.
Jeong‐Eun Han, Dae‐Seong Lee, Su‐Won Jeong, Ji‐Hyun Yun, Seomin Kang, Seoyoung Jang, EunAh Lee, Ju Hye Baek, Che Ok Jeon, Jin‐Woo Bae   +9 more
wiley   +1 more source

Neddylation Targets and Stabilizes NLRP3 to Augment Inflammasome‐Mediated Colitis and Mood Disorder

Advanced Science, EarlyView.
NLRP3 inflammasome contributes to colitis and mood disorder. This study demonstrates that neddylation targets NLRP3 at K287, which hinders its interaction with K48‐linked ubiquitination E3 Trim31 and thereby stabilizes it. Neddylation blockade in myeloid cells and microglia mitigates DSS‐induced colitis and psychological stress‐induced anxiety‐like ...
Wenbin Gai, Mengyao Wu, Anbiao Wu, Zhaofei Jing, Zhenjie Ye, Jiayan Jin, Yaolin Zhang, Min Zhao, Genyu Liu, Xu Wang, Xiqin Yang, Jie Dong, Yunlu Xu, Jiyan Zhang   +13 more
wiley   +1 more source

Interactions of Antibody Drug Conjugate Anti‐Tubulin and Topoisomerase I Inhibitor Payloads with Radiotherapy to Potentiate Immunotherapy

Advanced Science, EarlyView.
Antibody drug conjugates deliver their cytotoxic anti‐tubulin or topoisomerase I inhibitor payloads to tumors through cancer cell receptor targeting. The released drug payloads induce cellular changes that interact with radiotherapy resulting in radiosensitization that improves cancer cell kill and stimulates anti‐tumor immune responses.
Jacqueline Lesperance, Bryan S. Yung, Michael M. Allevato, Marcus M Cheng, Maria F. Camargo, Robert Saddawi‐Konefka, Kanika Dhawan, Ashwyn K. Sharma, Mahsa Mortaja, Sophie Bice, Daniel J. Scanderbeg, Diego Alvarado, Jyoti Mayadev, Ramez N. Eskander, Stephen R. Adams, Pippa F. Cosper, J. Silvio Gutkind, Sunil J. Advani   +17 more
wiley   +1 more source

Accuracy and Precision of Tympanic Temperature in the Reflection of Core Temperature

نشریه پرستاری ایران, 2006
Background & Aim: Monitoring of patients' temperature is an important nursing clinical procedure. Body temperature is usually taken at different sites including pulmonary artery, rectal, oral, and axillary areas.
M. Shamshiri, D. Masroor, ES Hajikazemi, H. Haghani   +3 more
doaj  

Antifreeze Proteins in the Primary Urine of Larvae of the Beetle \u3cem\u3eDendroides canadensis\u3c/em\u3e [PDF]

, 2013
To avoid freezing while overwintering beneath the bark of fallen trees, Dendroides canadensis (Coleoptera: Pyrochroidae) larvae produce a family of antifreeze proteins (DAFPs) that are transcribed in specific tissues and have specific compartmental fates.
Blumenthal, Edward M, Duman, John G., Nickell, Philip K., Sass, Sandra, Verleye, Dawn   +4 more
core   +1 more source

Pre-cooling for endurance exercise performance in the heat: a systematic review. [PDF]

, 2012
PMCID: PMC3568721The electronic version of this article is the complete one and can be found online at: http://www.biomedcentral.com/1741-7015/10/166. This is an Open Access article distributed under the terms of the Creative Commons Attribution License
AC Burton, B Nielsen, C Tyler, CG Maher, Christian Barton, CR Abbiss, D Kay, DJ McCann, DT Lee, DT Martin, Dylan Morrissey, F Marino, FE Marino, GA Selkirk, GF Ranalli, H Hasegawa, H Olschewski, J Booth, J González-Alonso, J Webster, JA Sterne, JD Cotter, JD MacDougall, JJ Peiffer, K Brück, M Cabanac, M Gleeson, M Ihsan, MA Febbraio, MA Merrick, MJ Price, MJ Quod, MJ Quod, ML Ross, MN Sawka, MN Sawka, N Bogerd, N El Helou, NA de Morton, Nicola Maffulli, P Sedgwick, Paul R Jones, R Duffield, R Eccles, R Siegel, R Siegel, RJ Maughan, RM Smith, S Uckert, SA Arngrïmsson, SA Tenaglia, SD Galloway, Stephanie Hemmings, TD Noakes, TL Vanden Hoek, TT Romet, V Hessemer, V Schmidt   +57 more
core   +2 more sources

Exclusive Breastfeeding Drives AMPK‐Dependent Thermogenic Memory in BAT and Promotes Long‐Term Metabolic Benefits in Offspring

Advanced Science, EarlyView.
Exclusive breastfeeding establishes a thermogenic memory in brown adipose tissue by activating the HIF1AN/AMPK/α‐ketoglutarate axis via milk‐derived extracellular vesicles enriched in miR‐125a‐5p. This programming preserves metabolic health, while αKG supplementation restores BAT function under mixed feeding, offering strategies to mitigate the ...
Ningxi Wu, Anwen Yin, Xiang Yu, Mingxin Wang, Jiahui Zhang, Kerong Liu, Yutong Hou, Minkai Cao, Yiting Zhang, Xiaoxiao Zhang, Yao Gao, Xirong Guo, Le Zhang, Yun Li   +13 more
wiley   +1 more source

Scrotal Cooling Increases Rectal Temperature in Man

Experimental Biology and Medicine, 2002
The aim of this study was to evaluate the effect of scrotal cooling on rectal temperature in man. Pilot studies suggested that immersing the scrotum in a 30°C water bath increased rectal temperature, but immersing the scrotum in a 0°C water bath did not. Six healthy young men immersed their scrotums in a 35°C water bath for 11 min followed by 21 min at
Peter D, Vash, Thomas M, Engels, Fouad R, Kandeel, Frank, Greenway   +3 more
openaire   +2 more sources

The Effects of Men\u27s Lacrosse Protective Equipment on Thermoregulation and Perceptions During Exercise Heat Stress [PDF]

, 2019
The effects of men\u27s lacrosse protective equipment on thermoregulation and perceptions during exercise heat stress Amanda P. Glasgow: Exercise Science Research Center, University of Arkansas, Fayetteville, AR.
Glasgow, Amanda
core   +3 more sources

Western Diet Inhibits FUT7‐Mediated Treg Intestinal Homing to Disrupt the Homeostasis of Intestinal Epithelial Cells in Crohn's Disease

Advanced Science, EarlyView.
In this study, we constructed a nanoparticle that was CD4 antibody‐mediated targeted, Fut7‐expressing plasmid‐loaded cationic liposome, namely CD4‐LDP‐Fut7. Upregulation of Fut7 expression in Tregs by using CD4‐LDP‐Fut7 can increase Treg homing to the intestine, thereby facilitating repair of the intestinal epithelial barrier and inhibiting ...
Qian Zhou, Xianfei Wang, Teng Ben, Chunping Zhu, Xinlong Lin, Yinmu Li, Xinyue Zhang, Yeling Chen, Yuchen Xuan, Huaiwen Chen, Ke Liu, Fang Wu, Yuexin Ren, Gao Tan   +13 more
wiley   +1 more source