Results 41 to 50 of about 1,095,269 (268)
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
On L′ (2, 1)–Edge Coloring Number of Regular Grids
Analele Stiintifice ale Universitatii Ovidius Constanta: Seria Matematica, 2019 In this paper, we study multi-level distance edge labeling for infinite rectangular, hexagonal and triangular grids. We label the edges with non-negative integers.
Deepthy D., Kureethara Joseph Varghese
doaj +1 more source
Effect of Corner Shape on Hydraulic Performance of One-Cycle Rectangular Labyrinth Weirs
Fluids, 2020 The hydraulic performance of rectangular labyrinth weirs has been investigated by many researchers, however, the effects of the corner shape on the hydraulic performance of rectangular labyrinth weirs have not been addressed in the current literature ...
Omed S. Q. Yousif, Moses Karakouzian
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Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Filling polygonal holes with bicubic patches [PDF]
, 1991 Consider a bicubic rectangular patch complex which surrounds an n-sided hole in R3.
Gregory, JA, Zhou, J
core
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Rectangular Layouts and Contact Graphs [PDF]
, 2006 Contact graphs of isothetic rectangles unify many concepts from applications including VLSI and architectural design, computational geometry, and GIS. Minimizing the area of their corresponding {\em rectangular layouts} is a key problem.
Buchsbaum, Adam L. +3 more
core +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Energies, 2018 The dynamics of liquid water in the gas channels with rectangular sections (REC), trapezoidal sections with open angles of 60 degrees (T60), and trapezoidal sections with open angles of 72 degrees (T72) are numerically investigated via the volume of ...
Jin Hyun Kim, Woo Tae Kim
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Multiobjective Geometric Analysis of Stiffened Plates under Bending through Constructal Design Method [PDF]
Journal of Applied and Computational Mechanics, 2020 Constructal design, finite element method and exhaustive search are applied to analyze different arrangements of steel plates with rectangular or trapezoidal stiffeners.
Vinícius Torres Pinto +4 more
doaj +1 more source