Results 151 to 160 of about 622,442 (395)

The application of cytology in the diagnosis of cancer of the rectum, sigmoid, and descending colon [PDF]

, 1952
G Bader, George N. Papanicolaou
openalex   +1 more source

FXYD3 Promotes Tumor Progression by Binding With IRF7 to Regulate JAK2/STAT5 Signaling in Intrahepatic Cholangiocarcinoma

Advanced Science, EarlyView.
FXYD3 binds IRF7 via its 60–87aa domain, triggering a cGAS/STING‐mediated positive feedback loop amplified by type I interferon. This sustains JAK2/STAT5 activation, accelerating ICC progression. Targeting FXYD3 with siFXYD3@PEP suppresses tumors and enhances chemotherapy sensitivity. Abstract Intrahepatic cholangiocarcinoma (ICC) has a poor prognosis,
Yan Zhou, Xiaofeng Shen, Shuo Zhang, XiaoHong Pu, Zipeng Xu, Xiang Zhao, Wei Feng, Yuan Liang, Xingtao He, Aihua Yang, Yudong Qiu, Yihang Yuan, Chaobo Chen, Jun Chen   +13 more
wiley   +1 more source

Aloe‐Emodin Targeting FOXC2 Disrupts NETs Formation and EMT‐Driven Postoperative Peritoneal Adhesion Through TGF‐β1‐Smad2/3 Pathway

Advanced Science, EarlyView.
Forkhead box protein C2 (FOXC2) is highlighted as a pivotal effector in postoperative peritoneal adhesion (PPA) formation. Mechanically, FOXC2 mediates NETs‐induced EMT alterations through the TGF‐β1‐Smad2/3 pathway. Aloe‐emodin (AE) ameliorates FOXC2‐driven fibrosis by blocking NETs formation and EMT changes through this pathway.
Lili Yang, Yunda Fang, Yuheng Lian, Ziyang Kong, Jia Miao, Yanqi Chen, Wen Li, Feiyan Chen, Bin Zhang, Yao Chen, Yaoyao Bian   +10 more
wiley   +1 more source

The Surgical Anatomy of the Anal Canal and Rectum [PDF]

, 1936
C. Naunton Morgan
openalex   +1 more source

Alkaline–Acid Intestine Environment Controlled by A Carbonic Anhydrase Gene Influences Synthesis of Sex Pheromone by Symbionts

Advanced Science, EarlyView.
A model proposing that elevated rectal expression of CAh1 in males alkalinizes the environment to regulate Bacillus production of a male‐specific sex pheromone. Abstract The intricate interplay between animals and their intestinal microbes is pivotal in shaping various aspects of animal biology.
Shiyu Gui, Lexin Xie, Zhenghao Wang, Yan Chen, Yi Xiao, Ziyun Lin, Jingxiang Chen, Yongyue Lu, Laurent Keller, Daifeng Cheng   +9 more
wiley   +1 more source

Multi-Omics Integration Reveals the Impact of Gastrointestinal Microbiota on Feed Efficiency in Tan Sheep

Microorganisms
The rumen and intestinal microbiota play a pivotal role in the digestion and absorption processes of ruminants. Elucidating the mechanisms by which gastrointestinal microbiota influence the feed conversion ratio (FCR) in ruminants is significantly ...
Guohan Sun, Xiaohong Han, Tonggao Liu, Xinrui Zhang, An Shi, Chong Yang, Jinzhong Tao   +6 more
doaj   +1 more source

ARL5B Drives Esophageal Squamous Cell Carcinoma Progression via ROCK1–SREBP1‐Mediated Lipid Metabolic Reprogramming

Advanced Science, EarlyView.
Esophageal squamous cell carcinoma urgently requires new therapeutic strategies. Adenosine diphosphate‐ribosylation factor‐like protein 5B (ARL5B) is identified as a novel oncogene that remodels fatty acid metabolism through the ras homologous‐associated coiled‐coil containing protein kinase 1 (ROCK1)–sterol regulatory element‐binding protein 1 (SREBP1)
Xinyue Ma, Yanfei Sun, Hongyuan Mao, Chenhan Huang, Zerun Li, Tianzi Wang, Dizhi Jiang, Xinyu Zhang, Zhenyu Yuan, Zhihui Zhang, Bo Cheng, Ruiqing Wang, Yufeng Cheng   +12 more
wiley   +1 more source

Retention of Urine after Excision of Rectum [PDF]

, 1938
H. T. Simmons
openalex   +1 more source

The High‐Altitude Adaptation Characteristics of Microbiota‐Host Cross‐Talk in Yak Gastrointestinal Track

Advanced Science, EarlyView.
In this study, a single‐cell atlas of 117,019 yak gastrointestinal cells across 54 subtypes identified HNF4A and SREBF2 as key transcription factors targeting MYO6 gene. Cross‐species and multi‐omics analyses reveals epithelial cells as key regulators that, through interactions with microbes, particularly Bacillus, facilitate flexible energy supply and
Chun Huang, Minghao Zhang, Qingbo Zheng, Qinran Yu, Guowu Yang, Wenwen Ren, Xiaoming Ma, Yongfu La, Pengjia Bao, Min Chu, Xian Guo, Chunnian Liang, Ping Yan   +12 more
wiley   +1 more source

Comparative Analysis of the Immunohistochemical Expression of the Parkin and APC proteins in Polyps and Colorectal Adenocarcinomas

Brazilian Journal of Oncology
Introduction Colorectal carcinoma is the result of a series of mutations based on the adenoma-carcinoma sequence. We aimed to perform a comparative analysis of the immune expression of the parkin (PARK2 gene) and of the APC (APC gene ...
William Augusto Casteleins, Claudia Caroline Veloso da Silva-Camargo, Amanda Pereira Agostinho, Rosimeri Kuhl Svoboda Baldin, Bruno Ribeiro Batista, Jacqueline Nabhen, Marcia Olandoski, Lucia de Noronha, Vanessa Santos Sotomaior   +8 more
doaj   +1 more source