Results 71 to 80 of about 1,206,872 (317)

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

The role of probiotic supplementation in reducing Helicobacter pylori recurrence after classic quadruple therapy

Frontiers in Pharmacology
BackgroundHelicobacter pylori (H. pylori) infection remains a global public health issue, closely linked to peptic ulcer disease, gastric cancer, and MALT lymphoma.
Jie Zhao, Jieyun Chen, Yanqing Wang, Chen Zhu, Chenjing Xia, Wei Yang   +5 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Endoscopic management of large laterally spreading colorectal tumors (LSTs): a comparative study of techniques and outcomes

Zaporožskij Medicinskij Žurnal
Laterally spreading colorectal tumors (LSTs) are associated with a risk of high-grade dysplasia and potential malignant transformation. Endoscopic resection is the standard of care for non-invasive LSTs, with the choice of technique guided by lesion size,
V. S. Tkachov, O. M. Kiosov, A. V. Klymenko   +2 more
doaj   +1 more source

An Unusual Presentation of Low-grade Chondrosarcoma of the First Metatarsal Bone requiring extensive Resection: A Case Report [PDF]

Journal of Clinical and Diagnostic Research
Chondrosarcoma (CS) is one of the common malignant bone tumours arising from chondrocytes with variable degrees of malignancy. It is mainly noted in flat bones like the pelvis and scapula, and sometimes in long bones like the proximal femur.
D Udayakumar, V udaya, B suresh Gandhi, Naveen Jegaprasath   +3 more
doaj   +1 more source

A joint frailty model to estimate the recurrence process and the disease-specific mortality process without needing the cause of death.

, 2014
In chronic diseases, such as cancer, recurrent events (such as relapses) are commonly observed; these could be interrupted by death. With such data, a joint analysis of recurrence and mortality processes is usually conducted with a frailty parameter ...
Roch Giorgi, Belot, Aurélien, Remontet, Laurent, CENSUR working survival group, Giorgi, Roch, Virginie Rondeau, Rondeau, Virginie, Laurent Remontet, Aurélien Belot   +8 more
core   +1 more source

Analysis of Recurrence after Frontolateral Laryngectomy [PDF]

, 2017
Objective: This study aimed to evaluate the recurrence and survival of patients treated with frontolateral laryngectomy for T1 and T2 glottic laryngeal carcinoma.Methods: Patients who underwent frontolateral laryngectomy for glottic laryngeal carcinoma ...
Feda Bayrak, Onal, Kazim, BAYRAK, ASUMAN FEDA, Koray Balcı, Murat Songu, Yilmaz Ozkul, Ozkul, Yilmaz, Songu, Murat, Ates, Duzgun, Abdulkadir Imre, Yılmaz Özkul, Imre, Abdulkadir, Kazım Önal, Koray Balci, Kazim Onal, Balci, Koray, Duzgun Ates   +16 more
core   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Local recurrences for mixed germ cell tumors without scrotal violation, is metastatic disease around the corner? A case report

Future Science OA
We hereby report the case of a 40-year-old male, who initially underwent a left inguinal orchiectomy for a stage Is mixed germ cell tumor achieving an R0 status.
Georges Abi Tayeh, Constance Michel, Xavier Durand   +2 more
doaj   +1 more source