Results 71 to 80 of about 93,434 (284)

Transitions and multistability in macroevolutionary dynamics of large mammals [PDF]

open access: yesActa Palaeontologica Polonica
On multi-million-year timescales, the climate system of the Earth exhibits complex wandering behaviour. We investigate the evolutionary impacts of long-term climate change by analysing the dynamics of Cenozoic mammal evolution, looking for the presence ...
Simona Bekeraitė   +4 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

Recurrence plot features of ECG signals [PDF]

open access: yesProceedings of the First Joint BMES/EMBS Conference. 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Annual Fall Meeting of the Biomedical Engineering Society (Cat. No.99CH37015), 2003
Single beats from ECG recording were used to demonstrate how the nonlinear dynamical analysis method of recurrence plots can be used to qualitatively describe data. It is concluded that, for ECG examples, the characteristics of the signals that cause particular features of the recurrence plots are easily identified.
Mewett, David   +2 more
openaire   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

open access: yesMolecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak   +10 more
wiley   +1 more source

Recurrence plot analysis of irregularly sampled data

open access: yesPhysical Review E, 2018
Irregularly sampled time series usually require data preprocessing before a desired time-series analysis can be applied. We propose an approach for distance measuring of pairs of data points which is directly applicable to irregularly sampled time series.
Ozken, I.   +6 more
openaire   +3 more sources

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

open access: yesMolecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena   +15 more
wiley   +1 more source

Forecasting abrupt changes in foreign exchange markets: method using dynamical network marker

open access: yesNew Journal of Physics, 2014
We apply the idea of dynamical network markers (Chen et al 2012 Sci. Rep. http://dx.doi.org/10.1038/srep00342 ) to foreign exchange markets so that early warning signals can be provided for any abrupt changes.
Shunsuke Oya   +2 more
doaj   +1 more source

Recurrence quantification analysis of global stock markets [PDF]

open access: yes
This study investigates the presence of deterministic dependencies in international stock markets using recurrence plots and recurrence quantification analysis (RQA). The results are based on a large set of free float-adjusted market capitalization stock
Joao A. Bastos, Jorge Caiado
core  

Recurrence Plots for the analysis of Vegetation Health Index (VHI) [PDF]

open access: yes, 2015
Many satellite and information services, such as NOAA STAR, are providing maps displaying data about vegetation indices. Using the time-series that we can obtain from these maps, several analyses are possible. Here we propose the use of recurrence plots.
Sparavigna, Amelia Carolina
core   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

open access: yesMolecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi   +7 more
wiley   +1 more source

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