Results 51 to 60 of about 91,797 (258)

Transitions and multistability in macroevolutionary dynamics of large mammals [PDF]

Acta Palaeontologica Polonica
On multi-million-year timescales, the climate system of the Earth exhibits complex wandering behaviour. We investigate the evolutionary impacts of long-term climate change by analysing the dynamics of Cenozoic mammal evolution, looking for the presence ...
Simona Bekeraitė, Robertas Stankevič, Ivona Juchnevičiūtė, Kristian Agasøster Haaga, Andrej Spiridonov   +4 more
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Character-level linguistic biomarkers for precision assessment of cognitive decline: a symbolic recurrence approach

Frontiers in Aging Neuroscience
Early-stage Alzheimer's disease (AD) remains difficult to assess using conventional linguistic or cognitive assessments, which often overlook subtle and individualized disruptions in speech.
Kevin Mekulu, Faisal Aqlan, Hui Yang
doaj   +1 more source

Detection of Causal Relations in Time Series Affected by Noise in Tokamaks Using Geodesic Distance on Gaussian Manifolds

Entropy, 2017
: Modern experiments in Magnetic Confinement Nuclear Fusion can produce Gigabytes of data, mainly in form of time series. The acquired signals, composing massive databases, are typically affected by significant levels of noise.
Andrea Murari, Teddy Craciunescu, Emmanuele Peluso, Michela Gelfusa, JET Contributors   +4 more
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

A Novel and Accurate Recurrence Plot-Based Characterization of Speech Dynamics in Hyperfunctional Dysphonia, Laryngitis, and Vocal Fold Polyp

IEEE Access
The accurate and interpretable detection of pathological voice conditions remains a critical challenge in clinical speech analysis. Existing acoustic and deep learning–based approaches are majorly based on spectral or temporal representations that
Anisha G. Krishnan, G. Jyothish Lal, E. A. Gopalakrishnan   +2 more
doaj   +1 more source

Assessing Hydrograph Similarity and Rare Runoff Dynamics by Cross Recurrence Plots

Water Resources Research, 2019
This paper introduces a novel measure to assess similarity between event hydrographs. It is based on cross recurrence plots (CRP) and recurrence quantification analysis (RQA), which have recently gained attention in a range of disciplines when dealing ...
Dadiyorto Wendi, Bruno Merz, Norbert Marwan   +2 more
doaj   +1 more source

Detection of Spatio-Temporal Recurrent Patterns in Dynamical Systems

Frontiers in Applied Mathematics and Statistics, 2019
Background: The study of repetitive (quasi-periodic) spatio-temporal patterns in complex dynamical systems with a well defined spatial structure may be complicated if the recurrent behavior is confined to specific local regions, where it lasts for a ...
Pietro Bonizzi, Ralf Peeters, Stef Zeemering, Arne van Hunnik, Olivier Meste, Joël Karel   +5 more
doaj   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source