Results 71 to 80 of about 88,313 (244)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Bandwidth extension method based on nonlinear audio characteristics classification

open access: yesTongxin xuebao, 2013
A bandwidth extension method based on audio classification was proposed.Time series of audio signals were classified into four types based on recurrence plot and recurrence quantification analysis,and the fine spectrums were recovered by taking advantage
Li-yan ZHANG   +3 more
doaj   +2 more sources

Recurrence Quantification Analysis (RQA) of Toroidal End Tool Milling Process

open access: yesApplied Sciences
One type of milling process is the face milling of flat surfaces using a toroidal face cutter. A key feature of this process is that changes in the depth of the cut alter the entering angle, impacting milling dynamics by shifting cutting force ...
Lukasz Zylka   +4 more
doaj   +1 more source

Dynamic Natural Language Processing with Recurrence Quantification Analysis

open access: yesCoRR, 2018
Writing and reading are dynamic processes. As an author composes a text, a sequence of words is produced. This sequence is one that, the author hopes, causes a revisitation of certain thoughts and ideas in others. These processes of composition and revisitation by readers are ordered in time.
Rick Dale   +2 more
openaire   +2 more sources

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

open access: yesMolecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu   +13 more
wiley   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

open access: yesMolecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski   +10 more
wiley   +1 more source

Nonlinear dynamical analysis of GNSS data: quantification, precursors and synchronisation

open access: yesProgress in Earth and Planetary Science, 2018
The goal of any nonlinear dynamical analysis of a data series is to extract features of the dynamics of the underlying physical and chemical processes that produce that spatial pattern or time series; a by-product is to characterise the signal in terms ...
Bruce Hobbs, Alison Ord
doaj   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

open access: yesMolecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht   +3 more
wiley   +1 more source

Effect of the Long-Term Mean and the Temporal Stability of Water-Energy Dynamics on China’s Terrestrial Species Richness

open access: yesISPRS International Journal of Geo-Information, 2017
Water-energy dynamics broadly regulate species richness gradients but are being altered by climate change and anthropogenic activities; however, the current methods used to quantify this phenomenon overlook the non-linear dynamics of climatic time-series
Chunyan Zhang   +6 more
doaj   +1 more source

Recurrence quantification analysis for the identification of burst phase synchronisation

open access: yesChaos: An Interdisciplinary Journal of Nonlinear Science, 2018
In this work, we apply the spatial recurrence quantification analysis (RQA) to identify chaotic burst phase synchronisation in networks. We consider one neural network with small-world topology and another one composed of small-world subnetworks. The neuron dynamics is described by the Rulkov map, which is a two-dimensional map that has been used to ...
E. L. Lameu   +11 more
openaire   +5 more sources

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