Results 51 to 60 of about 120,359 (315)
Molecular Oncology, EarlyView.The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song +11 more
wiley +1 more source
Fibonacci and Lucas Polynomials in n-gon
Analele Stiintifice ale Universitatii Ovidius Constanta: Seria Matematica, 2023 In this paper, we bring into light, study the polygonal structure of Fibonacci polynomials that are placed clockwise on these by a number corresponding to each vertex. Also, we find the relation between the numbers with such vertices.
Kuloğlu Bahar +2 more
doaj +1 more source
Molecular Oncology, EarlyView.In patients treated with atezolizumab as a part of the MyPathway (NCT02091141) trial, pre‐treatment ctDNA tumor fraction at high levels was associated with poor outcomes (radiographic response, progression‐free survival, and overall survival) but better sensitivity for blood tumor mutational burden (bTMB).
Charles Swanton +17 more
wiley +1 more source
Molecular Oncology, EarlyView.Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed +8 more
wiley +1 more source
Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source
Semi-local convergence of Cordero's sixth-order method
AIMS MathematicsIn this paper, the semi-local convergence of the Cordero's sixth-order iterative method in Banach space was proved by the method of recursion relation. In the process of proving, the auxiliary sequence and three increasing scalar functions can be derived
Xiaofeng Wang, Ning Shang
doaj +1 more source
Floor and ceiling functions for Pell numbers [PDF]
Notes on Number Theory and Discrete MathematicsThe analytical study of the Pell number and the role of floor and ceiling functions into their computation is examined. Closed expressions of Pell numbers were initially derived using Binet's formula, followed by an asymptotic behavior study of the ...
İsmail Sulan, Mustafa Aşçı
doaj +1 more source
Applied Mathematics in Science and Engineering, 2022 A class of nonlinear variational problems describing incompressible fluids and solids by stationary Stokes equations given in a planar domain with a crack (infinitely thin flat plate in fluids) is considered.
Victor A. Kovtunenko, Kohji Ohtsuka
doaj +1 more source
Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma
Molecular Oncology, EarlyView.The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias +12 more
wiley +1 more source
Generating Special Curves for Cubic Polynomials
MathematicsAn algorithmic method is proposed to generate all cubic polynomials with a critical orbit relation. We generate curves (polynomials of parameters) that correspond to those functions with critical orbit relations.
Khudoyor Mamayusupov +4 more
doaj +1 more source