Results 61 to 70 of about 104,121,840 (292)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

On the reciprocal sum of the fourth power of Fibonacci numbers

Open Mathematics, 2022
Let fn{f}_{n} be the nnth Fibonacci number with f1=f2=1{f}_{1}={f}_{2}=1. Recently, the exact values of ∑k=n∞1fks−1⌊{\left({\sum }_{k=n}^{\infty }\frac{1}{{f}_{k}^{s}}\right)}^{-1}⌋ have been obtained only for s=1,2s=1,2, where ⌊x⌋\lfloor x\
Hwang WonTae, Park Jong-Do, Song Kyunghwan   +2 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Discovering the Fascinating Pattern in the Geometric Representation of Non-intersecting Chords on the Circle within the Motzkin Sequence

JOIV: International Journal on Informatics Visualization
This study explores the Motzkin sequence and introduces a new sequence, the Wing sequence, derived from a novel geometric representation of directed paths.
Haslinda Ibrahim, Maizon Mohd Darus, Sharmila Karim   +2 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Sequences of twice-iterated Δw-Gould–Hopper Appell polynomials

Journal of Taibah University for Science
In this paper, we introduce general sequence of twice-iterated [Formula: see text]-(degenerate) Gould–Hopper Appell polynomials (TI-DGHAP) via discrete [Formula: see text]-Gould–Hopper Appell convolution. We obtain some of their characteristic properties
Neslihan Biricik, Bayram Çekim, Mehmet Ali Özarslan   +2 more
doaj   +1 more source

A formal operator involving Fermatian numbers [PDF]

Notes on Number Theory and Discrete Mathematics
In this note, old and new properties of Fermatian numbers _zₙ= (1-zⁿ)/(1-z) are recalled. A new formal operator is defined and some identities and extensions are discussed.
Carlos M. da Fonseca, Anthony G. Shannon
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

THE OPTIMAL PRINCIPLE OF BELLMAN IN THE PROBLEM OF OPTIMAL MEANS DISTRIBUTION BETWEEN ENTERPRISES FOR THE EXPANSION OF PRODUCTION

Вестник университета, 2019
The method of dynamic programming has been considered, which is used in solving multiple problems in economics, on the example of using Bellman’s optimality principle for solving nonlinear programming problems.
A. Tarasenko, I. Egorova
doaj   +1 more source