Results 111 to 120 of about 3,363,564 (300)

Nonlinear system identification for predictive control using continuous time recurrent neural networks and automatic differentiation. [PDF]

open access: yes, 2008
In this paper, a continuous time recurrent neural network (CTRNN) is developed to be used in nonlinear model predictive control (NMPC) context. The neural network represented in a general nonlinear state-space form is used to predict the future ...
Cao, Yi, Al Seyab, Rihab Khalid Shakir
core   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

open access: yesFEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança   +2 more
wiley   +1 more source

Calcium and phosphorus balance and its significance for the course of recurrent peptic ulcer disease

open access: yesТерапевтический архив, 2013
AIM: To evaluate calcium and phosphorus balances during recurrent peptic ulcer disease (PUD) and to estimate the impact of found changes on the course of an ulcerative process, secretory and motor functions in the stomach/MATERIAL AND METHODS: Sixty ...
V V Chernin, L A Fomina
doaj  

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

open access: yesFEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

Deep learning-based pathway-centric approach to characterize recurrent hepatocellular carcinoma after liver transplantation

open access: yesHuman Genomics
Background Liver transplantation (LT) is offered as a cure for Hepatocellular carcinoma (HCC), however 15–20% develop recurrence post-transplant which tends to be aggressive.
Jeffrey To   +8 more
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

open access: yesFEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices   +3 more
wiley   +1 more source

Seeking functions for spinal recurrent inhibition

open access: yesThe Journal of Physiology, 2008
In this issue of The Journal of Physiology, Lamy et al. (2008) describe a rhythmic modulation of recurrent inhibition during walking in man. This provides some insight into the function of recurrent inhibition, first described by Renshaw (1941) as an inhibition of cat motoneurones produced by antidromic stimulation of the axons of neighbouring ...
openaire   +3 more sources

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Embodied sharpness: exploring the slicing gesture in political talk shows

open access: yesFrontiers in Psychology
This paper explores the Slicing gesture within German political talk shows, focusing on its role in recurrent gesture sequences observed in German political talk shows.
Silva H. Ladewig
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

open access: yesFEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge   +6 more
wiley   +1 more source

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