Results 101 to 110 of about 3,363,564 (300)

Retinal glycoprotein enrichment by concanavalin a enabled identification of novel membrane autoantigen synaptotagmin-1 in equine recurrent uveitis. [PDF]

, 2012
Complete knowledge of autoantigen spectra is crucial for understanding pathomechanisms of autoimmune diseases like equine recurrent uveitis (ERU), a spontaneous model for human autoimmune uveitis. While several ERU autoantigens were identified previously,
Cornelia A. Deeg, Amann, B., Naim, Hassan Y., Amann, Barbara, Hauck Stefanie M., Barbara Amann, Hassan Y. Naim, Swadzba Margarete E., Naim, H.Y., Naim Hassan Y., Hauck, S.M., Cornelia A Deeg, Swadzba, Margarete E., Margarete E. Swadzba, Deeg Cornelia A., Amann Barbara, Stefanie M Hauck, Stefanie M. Hauck, Hassan Y Naim, Deeg, Cornelia A., Hauck, Stefanie M., Margarete E Swadzba, Deeg, C.A., Swadzba, M.E.   +23 more
core   +2 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Reservoir computing with output feedback [PDF]

, 2011
Reinhart RF. Reservoir computing with output feedback. Bielefeld: Bielefeld University; 2011.A dynamical system approach to forward and inverse modeling is proposed. Forward and inverse models are trained in associative recurrent neural networks that are
Reinhart, René Felix, Reinhart, Felix
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

DESIGN-ADAPTIVE POINTWISE NONPARAMETRIC REGRESSION ESTIMATION FOR RECURRENT MARKOV TIME SERIES [PDF]

A general framework is proposed for (auto)regression nonparametric estimation of recurrent time series in a class of Hilbert Markov processes with a Lipschitz conditional mean.
Guerre
core  

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Times Series Forecasting using Chebyshev Functions based Locally Recurrent neuro-Fuzzy Information System

International Journal of Computational Intelligence Systems, 2017
The model proposed in this paper, is a hybridization of fuzzy neural network (FNN) and a functional link neural system for time series data prediction. The TSK-type feedforward fuzzy neural network does not take the full advantage of the use of the fuzzy
A.K. Parida, R. Bisoi, P.K. Dash, S. Mishra   +3 more
doaj   +1 more source

Green's functions of recurrence relations with reflection [PDF]

Journal of Mathematical Analysis and Applications, 2019
In this work we develop an algebraic theory of linear recurrence equations and systems with constant coefficients and reflection. We obtain explicit solutions and the Green's functions associated to different problems under general linear boundary conditions.
openaire   +2 more sources

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Emergence of syntax and word prediction in an artificial neural circuit of the cerebellum

Nature Communications
The cerebellum, interconnected with the cerebral neocortex, plays a vital role in human-characteristic cognition such as language processing, however, knowledge about the underlying circuit computation of the cerebellum remains very limited.
Keiko Ohmae, Shogo Ohmae
doaj   +1 more source