Results 201 to 210 of about 3,363,564 (300)

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Structural and dynamical strategies to prevent runaway excitation in reservoir computing. [PDF]

Front Comput Neurosci
Metzner C, Schilling A, Maier A, Kinfe T, Krauss P.   +4 more
europepmc   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Structure-Guided Discovery Reveals Recurrent Bioactive Peptide Architectures Across Coleoptera. [PDF]

Int J Mol Sci
Gonçalves TC, Teodoro JA, Amaral DT.
europepmc   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Spatial-Niche Perspective on the Heterogeneity and Functional Reprogramming of Tumor-Associated Macrophages in Digestive System Tumors. [PDF]

Cells
Zhang J, Huang Y, Zhang M, Lou J, Zhang S, Zhao S, Song Z, Zhang K, Jiang T, Zhang G.   +9 more
europepmc   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Comprehensive proteogenomic characterization reveals clinically relevant molecular subtypes associated with medulloblastoma progression. [PDF]

Exp Mol Med
Park SM, Kim KH, Yoon JH, D'Angelo F, Choi SA, Kim CI, Koo H, Park S, Kim H, Sundara Raj S, Kim SS, Park AK, Koh EJ, Kim SI, Shim YM, Kwang-Hoon L, Kim EE, Phi JH, Jo YS, Nam DH, Hwang D, Hyeon DY, Huh S, Kwon HJ, Ha S, Park S, Shin H, Kwon JT, Yoo H, Gwak HS, D Taylor M, Park BJ, Sa JK, Kim Y, Iavarone A, Park SH, Kim SK, Park JB.   +37 more
europepmc   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

Multi-omics profiling of recurrence-associated extrachromosomal circular DNA characteristics and its prognostic potential in lung adenocarcinoma. [PDF]

Precis Clin Med
Zhao X, Du X, Yang S, Chen S, Pu C, Fan H, Qiao M, Yang Y, Guo Y, Guo Z.   +9 more
europepmc   +1 more source