Results 201 to 210 of about 240,394 (261)

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Dynamic miRNA-host gene co-expression and functional regulation in response to salinity fluctuations during biological invasions. [PDF]

Mar Life Sci Technol
Yan W, Fu R, Huang X, Shenkar N, Zhan A.
europepmc   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

The Extrachromosomal DNA Fusion Factory: Extrachromosomal Genesis of Oncogenic Fusion Transcripts. [PDF]

Research (Wash D C)
Maimaitiyiming Y, Yang C, Hua Naranmandura.   +2 more
europepmc   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Hierarchical recurrent temporal prediction as a model of the mammalian dorsal visual pathway. [PDF]

PLoS Comput Biol
Klavinskis-Whiting S, King AJ, Harper NS.   +2 more
europepmc   +1 more source

Integrative Multi-Omics Analysis Reveals Molecular Signatures of Recurrence in Paired Primary and Recurrent High-Grade Serous Ovarian Cancer. [PDF]

Int J Mol Sci
Kim MA, Nam J, Shin HY, Kim JY, Jun A, Cho H, Han MR, Kim JH.   +7 more
europepmc   +1 more source

Dysregulation of post-translational modifications in glioma: advances in pathological mechanisms and clinical targeting strategies. [PDF]

J Transl Med
Wu J, Liu H, Li X, Huang H, Zhu H, Wang J, Yue H, Li R, Shu K, You C.   +9 more
europepmc   +1 more source