Reproductive Biology and Endocrinology, 2021 Background MicroRNAs (miRNAs) are small, non-coding RNAs that are dysregulated in many diseases and can act as biomarkers. Although well-studied in cancer, the role of miRNAs in embryo implantation is poorly understood.
Hong Zeng, Yu Fu, Lang Shen, Song Quan
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Preimplantation and postimplantation therapy for the treatment of reproductive failure
Journal of Human Reproductive Sciences, 2013 Treatment of patients with recurrent pregnancy losses and recurrent implantation failure can be instituted only when the underlying etiology is determined.
Pratap Kumar, Siddharth Mahajan
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Recurrent implantation failure: definition and management [PDF]
Reproductive BioMedicine Online, 2014 Recurrent implantation failure refers to failure to achieve a clinical pregnancy after transfer of at least four good-quality embryos in a minimum of three fresh or frozen cycles in a woman under the age of 40 years. The failure to implant may be a consequence of embryo or uterine factors.
C, Coughlan +9 more
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Biomolecular Markers of Recurrent Implantation Failure—A Review [PDF]
International Journal of Molecular Sciences, 2021 Currently, infertility affects 8–12% of reproductive age couples worldwide, a problem that also affects women suffering from recurrent implantation failure (RIF). RIF is a complex condition resulting from many physiological and molecular mechanisms involving dynamic endometrium–blastocyst interaction.
Aleksandra E. Mrozikiewicz +2 more
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Frontiers in Immunology, 2023 Pregnancy success is dependent on the establishment of maternal tolerance during the preimplantation period. The immunosuppressive function of regulatory T cells is critical to limit inflammation arising from implantation of the semi-allogeneic ...
Sarah Yull +13 more
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Serum relaxin levels are reduced in pregnant women with a history of recurrent miscarriage, and correlate with maternal uterine artery Doppler indices in first trimester [PDF]
, 2009 Objectives: Defective implantation is a mechanism for recurrent pregnancy loss (RPL). We sought to determine whether the serum expression of human relaxin-2 (RLX) is impaired in women with a history of RPL.
Bogic +30 more
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Recurrent pregnancy loss is associated with a pro-senescent decidual response during the peri-implantation window [PDF]
, 2020 During the implantation window, the endometrium becomes poised to transition to a pregnant state, a process driven by differentiation of stromal cells into decidual cells (DC).
Brighton, Paul (Paul J.) +12 more
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Uterine selection of human embryos at implantation [PDF]
, 2014 Human embryos frequently harbor large-scale complex chromosomal errors that impede normal development. Affected embryos may fail to implant although many first breach the endometrial epithelium and embed in the decidualizing stroma before being rejected ...
A Mertzanidou +44 more
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A giant mystery in giant cell myocarditis: navigating diagnosis, immunosuppression, and mechanical circulatory support. [PDF]
, 2020 Giant cell myocarditis is a rare but often devastating diagnosis. Advances in cardiac imaging and mechanical circulatory support have led to earlier and more frequent diagnoses and successful management. This disease state has wide variation in acuity of
Dunn, Steven P +3 more
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Impact of sitagliptin on endometrial mesenchymal stem-like progenitor cells : a randomised, double-blind placebo-controlled feasibility trial [PDF]
, 2020 Background: Recurrent pregnancy loss (RPL) is associated with the loss of endometrial mesenchymal stem-like progenitor cells (eMSC). DPP4 inhibitors may increase homing and engraftment of bone marrow-derived cells to sites of tissue injury.
Brighton, Paul (Paul J.) +13 more
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