Results 71 to 80 of about 20,734 (289)

Malectin Alleviates Endoplasmic Reticulum Stress in Gestational Diabetes Mellitus via Glycoprotein Quality Control Mechanisms

Advanced Science, EarlyView.
Malectin alleviates high glucose‐induced ER stress and damage in placental trophoblasts, a function dependent on its six critical carbohydrate‐binding residues. In a GDM mouse model, administration of TAT‐Malectin ameliorated hyperglycemia and placental ER stress and prevented fetal macrosomia.
Jiahui Zhu, Yumeng Zhang, Ye Wang, Xiaoyu Zhu, Ailin Yuan, Weijing Yin, Huangmin Yu, Xuemin Pang, Yufeng He, Yuchen Wang, Tong Wang, Yong Li, Yunlong Si   +12 more
wiley   +1 more source

Zinc Exposure Causes Disulfidptosis to Induce Miscarriage by Up‐Regulating GATA1/METTL1/SLC7A11 Axis

Advanced Science, EarlyView.
Zn exposure up‐regulates GATA1, promoting GATA1‐mediated METTL1 and SLC7A11 transcription. It also enhances METTL1‐mediated m7G modification on SLC7A11 mRNA, increasing SLC7A11 mRNA stability. Ultimately, Zn exposure up‐regulates SLC7A11 at both transcriptional and post‐transcriptional levels, causing disulfidptosis. Knockdown of murine Slc7a11, Gata1,
Wenxin Huang, Yi Sun, Yanxin Wang, Haijun Yan, Xiaoping Yue, Weidong Wu, Xueyu Chen, Jinfang Zhang, Yanbing Lin, Qiong Lei, Nan Ji, Shuaishuai Xing, Liqin Zeng, Qingzheng Kang, Depeng Zhao, Geng Guo, Huidong Zhang   +16 more
wiley   +1 more source

Testing for inherited thrombophilia in recurrent miscarriage

, 2011
Approximately 1-5% of women trying to conceive experience recurrent miscarriage, and in 50% of these women, the cause of the preceding miscarriages is unknown.
Mariëtte Goddijn, Paulien de Jong, Saskia Middeldorp, Goddijn, Mariëtte, de Jong, Paulien G., Middeldorp, Saskia   +5 more
core   +1 more source

Targeting Supramolecular Active Complexes of Nav1.7/Nav1.8 to Relieve Chronic Neuropathic Pain

Advanced Science, EarlyView.
In mice and patients with severe chronic neuropathic pain (NP), Nav1.7, Nav1.8, TrkB, and five cytoskeletal proteins form supramolecular active complexes (SMACs) with polygonal lattice structures as noxious signal amplifiers in dorsal root ganglion (DRG) neurons.
Liting Sun, Hang Xian, Yunxin Shi, Taotan Yang, Hongyan Shuai, Wenchao Hu, Siying Fei, Miao Xu, Taoyuan Yang, Ruilong Xia, Ting Wen, Fengting Zhu, Yan Fu, Yang Li, Wei Xia, Ran Qian, Yuanying Liu, Zhicheng Tian, Lamei Li, Qian Zhou, Lize Xiong, Rui Cong, Ceng Luo, Shengxi Wu, Xiafeng Shen, Xin Yu, Rou‐Gang Xie, Changgeng Peng   +27 more
wiley   +1 more source

Ectopic pregnancy in women with recurrent miscarriage

, 2018
The aim of this study was to investigate the possible association between recurrent miscarriage (RM) and ectopic pregnancy (EP)
Capogna M. V., Ergasti R., Pietropolli A., Piccione E., Ticconi C., Borelli B., Martelli F., Bruno V., Sorge R.   +8 more
core   +2 more sources

The LncRNA PRNCR1 rs13252298 GG genotype is correlated with reducing susceptibility to recurrent spontaneous miscarriage in a southern Chinese population

SAGE Open Medicine
Background: LncRNAs play diverse roles and participate in various biological processes within the human body. It has been frequently reported that they are involved in the occurrence and development of recurrent spontaneous miscarriage.
Hanran Mai, Junyi Ke, Xilian Luo, Zilin Zheng, Jieyi Luo, Chenlu Wang, Yueling Lin, Menghua He, Yanxia Qu, Yufen Xu, Lanyan Fu, Lei Pi, Huazhong Zhou, Xiaoqiong Gu, Di Che, Liandong Zuo   +15 more
doaj   +1 more source

Acute Stress Response in Women with Recurrent Miscarriage and Infertility

Nepalese Medical Journal, 2018
Introduction: Stress has been linked to reproductive failure which includes miscarriage and Infertility. Several studies showed high levels of psychological stress and stress biomarkers in women with reproductive failure.
Sunita Bhandari
doaj   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Progesterone supplementation in women with otherwise unexplained recurrent miscarriages

Journal of Human Reproductive Sciences, 2012
Context: Recurrent miscarriages, the loss of three or more consecutive intrauterine pregnancies before 20 weeks of gestation with the same partner, affect 1%-1.5% of the pregnant population. The inadequate secretion of progesterone in early pregnancy has
Munawar Hussain, Samawal El-Hakim, David J Cahill   +2 more
doaj   +1 more source

Lymphocyte immunotherapy in the treatment of recurrent miscarriage: systematic review and meta-analysis

, 2017
Purpose: Recurrent miscarriage (RM) affects up to 2–3% of couples of reproductive age. There are several causes for this condition, including immunologic.
Costa, Fabricio Da Silva, Sarno, Manoel, Araujo Junior, Edward, Barini, Ricardo, Cavalcante, Marcelo Borges   +4 more
core   +1 more source