Results 81 to 90 of about 911,944 (331)

Plant Genetic Engineering: Technological Pathways, Application Scenarios, and Future Directions

Advanced Science, EarlyView.
This review maps the fast‐evolving landscape of plant genetic engineering, linking enabling platforms with trait‐focused applications in architecture optimization, stress resilience, yield improvement, and quality enhancement. It highlights how genome editing, transgenic strategies, and emerging multi‐gene approaches reshape breeding pipelines, while ...
Peilin Wang, Wenzhi Wang, Dongjiao Wang, Qibin Wu, Youxiong Que   +4 more
wiley   +1 more source

Acute Stress Response in Women with Recurrent Miscarriage and Infertility

Nepalese Medical Journal, 2018
Introduction: Stress has been linked to reproductive failure which includes miscarriage and Infertility. Several studies showed high levels of psychological stress and stress biomarkers in women with reproductive failure.
Sunita Bhandari
doaj   +1 more source

Slow Fetal Heart Rate before Miscarriage in the Early First Trimester Predicts Fetal Aneuploidy in Women with Recurrent Pregnancy Loss [PDF]

, 2018
Establishing whether miscarriages result from fetal aneuploidy or other factors is important for treating recurrent pregnancy loss. We examined the relationship between fetal heart rate (FHR) before miscarriage in the early first trimester and fetal ...
Hasegawa, Toru, Hiramatsu, Yuji, Kamada, Yasuhiko, Kotani, Sayoko, Kubo, Kotaro, Nakatsuka, Mikiya, Sakamoto, Ai   +6 more
core   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Progesterone supplementation in women with otherwise unexplained recurrent miscarriages

Journal of Human Reproductive Sciences, 2012
Context: Recurrent miscarriages, the loss of three or more consecutive intrauterine pregnancies before 20 weeks of gestation with the same partner, affect 1%-1.5% of the pregnant population. The inadequate secretion of progesterone in early pregnancy has
Munawar Hussain, Samawal El-Hakim, David J Cahill   +2 more
doaj   +1 more source

Endometrial Epithelial Lactate Deficiency Drives CD8+ T‐Cells Dysregulation in Unexplained Recurrent Implantation Failure

Advanced Science, EarlyView.
Unexplained recurrent implantation failure (RIF) represents a significant clinical challenge. Our results demonstrate that reduced lactate production in the RIF endometrium impairs the suppression of cytotoxic CD8+ T‑cells, allowing their proliferation and thereby disrupting the local immune balance essential for successful embryo implantation.
Yuanlin He, Kang Ke, Qingxia Meng, Yichun Guan, Jichun Tan, Hong Lv, Boxian Huang, Chan Tian, Qinyan Zou, Mingxing An, Yao Gao, Jingjing Chen, Xiaoyu Wei, Xi Wang, Hongxia Ma, Yuan Lin, Feiyang Diao, Yayun Gu, Zhibin Hu   +18 more
wiley   +1 more source

The LncRNA PRNCR1 rs13252298 GG genotype is correlated with reducing susceptibility to recurrent spontaneous miscarriage in a southern Chinese population

SAGE Open Medicine
Background: LncRNAs play diverse roles and participate in various biological processes within the human body. It has been frequently reported that they are involved in the occurrence and development of recurrent spontaneous miscarriage.
Hanran Mai, Junyi Ke, Xilian Luo, Zilin Zheng, Jieyi Luo, Chenlu Wang, Yueling Lin, Menghua He, Yanxia Qu, Yufen Xu, Lanyan Fu, Lei Pi, Huazhong Zhou, Xiaoqiong Gu, Di Che, Liandong Zuo   +15 more
doaj   +1 more source

Trained Memory of Uterine Macrophages Improves Subsequent Pregnancy Outcomes

Advanced Science, EarlyView.
This study identifies that pregnancy imprints a durable, pregnancy‐specific form of trained immune memory in uterine macrophages, marked by the emergence of LILRB3+/PIR‐B+ cells that expand across gestations, acquire a tolerogenic and metabolically rewired phenotype, and actively protect against inflammatory pregnancy loss in mice.
Jing Wang, Ning Lu, Xin‐Xiu Lin, Xu‐Hui Fang, Yi‐Hui Li, Qing‐Peng Luo, Yu‐Ting Peng, Gil Mor, Ai‐Hua Liao   +8 more
wiley   +1 more source

Lifetime Estrogen Exposure, Cumulative Lifetime Stress, and Cognition in Later Life [PDF]

, 2018
The main goal of this study was to begin to examine how stress and estrogen work together to influence memory and thinking in older women. We looked at how stressful experiences affected memory in older women and how the hormone estrogen influenced the ...
Senft Miller, Anna Erika
core   +1 more source

ALIFE2 study : low-molecular-weight heparin for women with recurrent miscarriage and inherited thrombophilia : study protocol for a randomized controlled trial [PDF]

, 2015
Background A large number of studies have shown an association between inherited thrombophilia and recurrent miscarriage. It has been hypothesized that anticoagulant therapy might reduce the number of miscarriages and stillbirth in these women.
Bloemenkamp, Kitty W. M., Braams-Lisman, Babette A. M., Bruin, Jan Peter de, Coomarasamy, Arri, David, Michele, DeSancho, Maria T., Goddijn, Mariëtte, Hoek, Annemieke, Hutten, Barbara A., Jochmans, Kristin, Jong, Paulien G. de, Koks, Carolina A. M., Kuchenbecker, Walter Karl Hermann, Middeldorp, Saskia, Mol, Ben W. J., Quenby, Siobhan, Scheepers, Hubertina Catharina Johanna, Stephenson, Mary D., Torrance, H. L., van der Heijden, Olivier W. H., Verhoeve, Harold R., Visser, Jantien, Vries, Johanna Inge Petra de   +22 more
core   +1 more source