Results 71 to 80 of about 891,540 (202)

Efficacy and Safety of Pharmaceutically Manufactured Cannabidiol in Recurrent Pericarditis: A Phase II Clinical Trial

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Recurrent pericarditis may be mediated through inappropriate activation of the NACHT, leucine‐rich repeat, and pyrin domain‐containing protein 3 inflammasome. Pharmaceutically manufactured cannabidiol is an oral formulation that inhibits NACHT,
Sushil Allen Luis, Allan L. Klein, Paul C. Cremer, Antonio Abbate, Jonathan R. Salik, Georgia K. Thomas, Syed Waqas Haider, Tracy E. Hagerty, David Lin, Thomas E. Waggoner, Stephen J. Nicholls, Bridget‐Anne Kirwan, Kelly A. D. Narine, Andrea B. Parker, Andrew Hamer   +14 more
doaj   +1 more source

INtraVESical immunoTherapy (INVEST) prior to radical cystectomy for bladder cancer: trial protocol

BJU International, EarlyView.
Background High‐risk non‐muscle‐invasive bladder cancer (HRNMIBC) has a variable prognosis, managed predominantly by local surgical resection and intravesical Bacillus Calmette–Guérin (BCG), or radical cystectomy (RC). Current treatments are poorly tolerated, have supply limitations and often fail to control the disease.
Ruby Lister‐Whelan, Ethan Senior, Jessica Kendall, Jamie B. Oughton, Fiona Collinson, Jon Griffin, Rachel Hubbard, Steven Kennish, Aidan Noon, Derek J. Rosario, Irbaz B. Riaz, Julie Telliez, James W. F. Catto, Syed A. Hussain   +13 more
wiley   +1 more source

Evaluation and management of recurrent pericarditis in special populations: A contemporary review

Brain & Heart
About 15 – 30% of patients develop recurrent episodes of pericarditis following an acute pericarditis attack. In developed countries, most cases of pericarditis are of idiopathic etiology.
Harsha Sanaka, E. Haroun, Karl Abou Zeid, A. D. Arockiam, Allan L Klein, Tom Kai Ming Wang   +5 more
semanticscholar   +1 more source

Novel therapeutic targets for chronic visceral pain in gastrointestinal disorders

British Journal of Pharmacology, EarlyView.
Chronic visceral pain imposes a major clinical challenge in gastroenterology and beyond, profoundly impacting patients' quality of life. However, limited understanding of its complex, multifaceted pathophysiology, encompassing both peripheral and central mechanisms, continues to impede the development of effective management strategies.
Fleur Veldman, Christopher J. Black, Andrea Shin, Daniel Keszthelyi   +3 more
wiley   +1 more source

Return-to-play in an endurance athlete with recurrent pericarditis and transient pericardial constriction: A case report

Apunts Sports Medicine
Recurrent pericarditis management is a significant challenge, especially in athletes, due to the recommendation of exercise restriction. It requires a comprehensive, multidisciplinary approach balancing treatment efficacy with a tailored return-to-play ...
Mireia Guarner Piquet
doaj   +1 more source

Untying the Gordian knot of pericardial diseases: A pragmatic approach

Hellenic Journal of Cardiology, 2016
Pericardial disorders constitute a relatively common cause of heart disease. Although acute pericarditis, especially the idiopathic forms that are the most prevalent, is considered a benign disease overall, its short- and long-term complications, namely,
George Lazaros, Massimo Imazio, Antonio Brucato, Dimitrios Tousoulis   +3 more
doaj   +1 more source

Acute anaphylactic and multiorgan inflammatory effects of Comirnaty in pigs: evidence of spike protein mRNA transfection and paralleling inflammatory cytokine upregulation

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Rare but severe adverse events (AEs) associated with mRNA‐lipid nanoparticle (LNP) COVID‐19 vaccines, such as Comirnaty, include anaphylaxis and inflammatory organ disorders, but their underlying mechanisms are poorly understood. We aimed to develop an animal model to study these phenomena.
László Dézsi, Gábor Kökény, Gábor Szénási, Csaba Révész, Tamás Mészáros, Bálint A. Barta, Réka Facsko, Anna Szilasi, Tamás Bakos, Gergely T. Kozma, Attila B. Dobos, Béla Merkely, Tamás Radovits, János Szebeni   +13 more
wiley   +1 more source

Expanding the Therapeutic Landscape of Pericarditis: A Systematic Review of the Use of Conventional Immunosuppressants

Medicina
Background and Objectives: While interleukin-1 inhibitors represent the standard of care for refractory idiopathic recurrent acute pericarditis, current guidelines also endorse conventional immunosuppressive (IS) agents as potential alternatives. The use
Andrea Silvio Giordani, Caterina Menghi, Antonella Risoli, Anna Baritussio, Federico Scognamiglio, Matteo Castegnaro, Elena Pontara, Maria Grazia Cattini, Elisa Bison, Celeste Ambra Murace, Elena Verrecchia, Marco Giuseppe Del Buono, Francesco Landi, Ludovico Luca Sicignano, Alida Linda Patrizia Caforio   +14 more
doaj   +1 more source

Arrhythmias associated with immune checkpoint inhibitor therapy—A clinical perspective

British Journal of Pharmacology, EarlyView.
Immune checkpoint inhibitors (ICIs) have transformed cancer therapy but are associated with a growing spectrum of cardiovascular immune‐related adverse events. Among these, arrhythmias represent a rare yet potentially life‐threatening complication. ICI‐induced arrhythmias encompass a wide clinical spectrum, including atrial arrhythmias, conduction ...
Dong Wang, Melanie Ricke‐Hoch, David Duncker, Johann Bauersachs, Dominik Berliner   +4 more
wiley   +1 more source

Mental Health Disorders in End‐Stage Kidney Disease: A Narrative Review of Clinical Considerations for Integrated Management

Hemodialysis International, EarlyView.
ABSTRACT Introduction End stage kidney disease (ESKD) is associated with a high prevalence of depression and anxiety, arising from both biological factors and the psychosocial burden of chronic dialysis care. Approximately 25%–30% of dialysis patients experience clinically significant depressive symptoms when assessed by structured clinical interview ...
Kunal Malhotra, Jordan Fangue‐Nelon, Garima Singh   +2 more
wiley   +1 more source