Results 51 to 60 of about 2,670,868 (221)

Association of tumor necrosis factor-alpha 308G/A polymorphism with recurrent miscarriages in women

Journal of Human Reproductive Sciences, 2016
BACKGROUND: Recurrent miscarriage (RM) is the most common pregnancy loss in the first trimester affecting approximately 0.5–2% of women. It is a heterogeneous condition and remains an enigma as the underlying cause is still difficult to track down.
Neha Sudhir, Badaruddoza, Archana Beri, Anupam Kaur   +3 more
doaj   +1 more source

A Novel Mutation in NLRP7 Related to Recurrent Hydatidiform Mole and Reproductive Failure [PDF]

International Journal of Fertility and Sterility, 2019
Background Hydatidiform mole (HM) is an abnormal human pregnancy with excessive trophoblastic proliferation and abnormal embryonic development, dividing into two complete HM (CHM) and partial HM (PHM) groups.
Jafar Fallahi, Vahid Razban, Mozhdeh Momtahan, Mojgan Akbarzadeh-Jahromi, Bahia Namavar-Jahromi, Zahra Anvar   +5 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Debate 6: Microbiome Testing is Indicated for Implantation Failure in 2023 Motion For – Author: Mary Louise Hull; Motion Against – Author: Rong Li

Fertility & Reproduction, 2023
Motion: For Uninvestigated Recurrent Implantation Failure (RIF) has a significant cost, can waste embryos with the potential for life and leads to empirical therapies such as the use of steroids.
Mary Louise Hull, Rong Li
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

The paradox of pregnancy : an update on the immunology of early pregnancy [PDF]

, 2008
Pregnancy is an altered physiological state where an organism essentially foreign to the individual carrying it, grows, develops and at an appropriate time probably initiates a series of signals which lead to its safe expulsion from the woman's body. The
Formosa, Mark
core  

Sequential embryo transfer combined with intrauterine perfusion improved pregnancy outcomes in patients with recurrent implantation failure

BMC Women's Health
Objective To compare the application of sequential embryo transfer, cleavage embryo transfer, and blastocyst transfer combined with intrauterine perfusion in frozen–thawed embryo transfer cycles in patients with recurrent implantation failure to provide ...
Wenda Zou, Dan Liu, Juan Peng, Zhijing Tang, Yukun Li, Juan Zhang, Ziwei Liu   +6 more
doaj   +1 more source

Candida biofilm formation and recurrent vulvovaginal candidiasis [PDF]

Microbiology Australia, 2023
Recurrent vulvovaginal candidiasis (RVVC), a recalcitrant Candida infection of the lower female reproductive tract, is a difficult-to-treat medical condition affecting the morbidity of many otherwise healthy women.
Yue Qu, Xenia Kostoulias, Yao Sun
doaj  

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source