Results 51 to 60 of about 1,995,629 (215)

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Evaluation of the Predisposing Factors for Recurrent Respiratory Tract Infections in Iraqi Pediatric Patients.

Al-Mustansiriyah Journal of Pharmaceutical Sciences, 2014
Recurrent respiratory tract infections are responsible for about 85% of all diseases in childhood, and are associated with significant morbidity and mortality.
Fadya Yaqoob Al-Hamdani, Basma Zuheir Al-Mutawalli   +1 more
doaj   +1 more source

Age-dependent differences in the pathogenesis of bovine respiratory syncytial virus infections related to the development of natural immunocompetence [PDF]

, 2010
The severity of respiratory syncytial virus (RSV) infections appears to differ with age in both humans and bovines. A primary RSV infection in naïve infants and in young calves runs a more severe course when they are 1–6 months old than in their first ...
Most, R.G., van der, Stockhofe-Zurwieden, N., Schrijver, R.S., Antonis, A.F.G., Poel, W.H.M., van der, Jong, M.C., de, Kimman, T.G.   +6 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Metabolomic profile of children with recurrent respiratory infections

Pharmacological Research, 2017
Recurrent respiratory infections (RRI) represent a widespread condition which has a severe social and economic impact. Immunostimulants are used for their prevention. It is crucial to better characterize children with RRI to refine their diagnosis and identify effective personalized prevention strategies.
BOZZETTO, SARA, PIRILLO, PAOLA, CARRARO, SILVIA, Berardi, Mariangela, Cesca, Laura, STOCCHERO, MATTEO, GIORDANO, GIUSEPPE, Zanconato, Stefania, BARALDI, EUGENIO   +8 more
openaire   +3 more sources

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Unveiling Kartagener’s Syndrome in a Young Male: A Case Report [PDF]

Journal of Clinical and Diagnostic Research
Kartagener's Syndrome (KS) is a rare genetic condition that affects the cilia. It is characterised by a situs inversus triad, chronic sinusitis, and bronchiectasis, distinguishing it from other diseases.
Priyanka Kalpesh Negandhi, Sourya Acharya, Nitish Batra, Mohd Faizan Ulla Khan, Rahil Shaikh   +4 more
doaj   +1 more source

Prediction of recurrent course of respiratory infections in premature infants

Сучасна педіатрія: Україна, 2022
The problem of prevention of frequent respiratory diseases for children remains relevant. Among premature infants, the most vulnerable group are children with very low and extremely low birth weight.
E.B. Kozakevіch, V.K. Kozakevіch, L.S. Ziuzina, M.E. Fesenko, E.I. Melashchenko   +4 more
doaj   +1 more source

Global, Regional, and National Burden of Upper Respiratory Infections and Otitis Media, 1990–2021: A Systematic Analysis From the Global Burden of Disease Study 2021 [PDF]

Background: Upper respiratory infections (URIs) are the leading cause of acute disease incidence worldwide and contribute to a substantial health-care burden.
GBD 2021 Upper Respiratory Infections Otitis Media Collaborators, Solanki, Ranjan, GBD 2021 Upper Respiratory Infections Otitis Media Collaborators,, Luca Cegolon   +3 more
core   +1 more source

Five‐Year Outcomes of Laparoscopic Sphincter‐Preserving Surgery for Rectal Cancer: A Prospective Study in Elderly Vietnamese Patients

Aging and Cancer, EarlyView.
This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho, Quang Le, Ngoc Thach Tran, Van Viet Ung, Loc Vu   +4 more
wiley   +1 more source