Results 11 to 20 of about 16,341 (256)

Pure Red Cell Aplasia [PDF]

Blood, 2016
AbstractPure red cell aplasia (PRCA) is a syndrome defined by a normocytic normochromic anemia with severe reticulocytopenia and marked reduction or absence of erythroid precursors from the bone marrow. Diamond-Blackfan anemia is a congenital form of PRCA.
R. Means
semanticscholar   +9 more sources

Clonal hematopoiesis in adult pure red cell aplasia

Scientific Reports, 2021
Idiopathic pure red cell aplasia (PRCA) and secondary PRCA associated with thymoma and large granular lymphocyte leukemia are generally considered to be immune-mediated.
Naohito Fujishima, Junki Kohmaru, Souichi Koyota, Keiji Kuba, Tomoo Saga, Ayumi Omokawa, Yuki Moritoki, Shigeharu Ueki, Fumihiro Ishida, Shinji Nakao, Akira Matsuda, Akiko Ohta, Kaoru Tohyama, Hiroshi Yamasaki, Kensuke Usuki, Yasuhiro Nakashima, Shinya Sato, Yasushi Miyazaki, Yasuhito Nannya, Seishi Ogawa, Kenichi Sawada, Kinuko Mitani, Makoto Hirokawa   +22 more
doaj   +2 more sources

Pure red cell aplasia and seronegative myasthenia gravis in association with thymoma

Journal of Community Hospital Internal Medicine Perspectives, 2020
Pure red cell aplasia is an uncommon paraneoplastic syndrome of thymoma. Myasthenia gravis is the most common paraneoplastic syndrome associated with thymoma. We present a case of a 79-year-old Pacific Islander female who presented with profound fatigue,
Sun Yong Lee, Amandeep Gill, Syung Min Jung   +2 more
doaj   +2 more sources

Rational management approach to pure red cell aplasia

Haematologica, 2018
Pure red cell aplasia is an orphan disease, and as such lacks rationally established standard therapies. Most cases are idiopathic; a subset is antibody-mediated.
Suresh Kumar Balasubramanian, Meena Sadaps, Swapna Thota, Mai Aly, Bartlomiej P. Przychodzen, Cassandra M. Hirsch, Valeria Visconte, Tomas Radivoyevitch, Jaroslaw P. Maciejewski   +8 more
doaj   +2 more sources

Phagocytosis of Lymphocytes and Erythrocytes by B-Cell Lymphoma in a Patient With a Clinical Suspicion of Pure Red Cell Aplasia. [PDF]

Clin Case Rep
ABSTRACT Herein, we report a diagnostically challenging case of a B‐cell lymphoma initially masquerading as pure red cell aplasia (PRCA). The key to diagnosis was the unique finding of phagocytic activity (engulfing erythrocytes and lymphocytes) by atypical mature lymphocytes in both peripheral blood and bone marrow, accompanied by clinical signs of ...
Cao T, Li Y, Peng X.
europepmc   +2 more sources

Immune-Mediated Multilineage Cytopenias in Thymoma: A Retrospective Case Series. [PDF]

Thorac Cancer
Thymoma‐associated immune dysregulation can drive multilineage cytopenias through T‐cell–mediated mechanisms. Patients show heterogeneous marrow involvement, frequent relapse, and variable lineage‐specific responses to immunosuppressive therapy, with sirolimus demonstrating activity in T‐cell‐driven phenotypes. ABSTRACT Background Thymoma is associated
Hu N, Wei Y, Lin W, Dong X, Wang H.
europepmc   +2 more sources

Pure Red Cell Aplasia (PRCA) and Cerebellar Hypoplasia as Atypical Features of Polyglandular Autoimmune Syndrome Type I (APS-1): Two Sisters With the Same AIRE Mutation but Different Phenotypes

Frontiers in Pediatrics, 2019
The polyglandular autoimmune syndrome type I is a rare hereditary autosomal recessive disease. We describe a child with the classic triad of the disease and her sister with pure red cell aplasia and cerebellar hypoplasia.
Matteo Chinello, Margherita Mauro, Gaetano Cantalupo, Rita Balter, Massimiliano De Bortoli, Virginia Vitale, Ada Zaccaron, Elisa Bonetti, Rossella Gaudino, Elena Fiorini, Simone Cesaro   +10 more
doaj   +2 more sources

Pure Red Cell Aplasia Associated With Thymic Tumors, a Nationwide Retrospective Study. [PDF]

Am J Hematol
ABSTRACT Pure red cell aplasia (PRCA) is the most frequent autoimmune cytopenia associated with thymic tumors (TTs). In a nationwide retrospective study, we included 41 patients (22 women, median age 62 years). At PRCA diagnosis, the mean hemoglobin level was 6.6 ± 2.1 g/dL, and the reticulocyte count was 6 ± 5 × 109/L. PRCA was diagnosed before TT (8%,
Hemmer M, Moinard S, Lambotte O, Malphettes M, Terriou L, Lioger B, Le Guenno G, Viallard JF, Michel M, Lobbes H.   +9 more
europepmc   +2 more sources

How I manage acquired pure red cell aplasia in adults.

Blood, 2021
Pure red cell aplasia (PRCA) is a rare hematological disorder with multiple etiologies. The multifaceted nature of this disease is emphasized by the variety of concomitant clinical features.
C. Gurnari, J. Maciejewski
semanticscholar   +1 more source

Daratumumab for treatment-refractory acquired idiopathic pure red cell aplasia

Haematologica, 2022
Not available.
Naseema Gangat, Jonathan Bleeker, Douglas Lynch, Horatiu Olteanu, Louis Letendre, Ayalew Tefferi   +5 more
doaj   +2 more sources