Results 181 to 190 of about 8,246,076 (287)

Distribution of poly(A) polymerase I in bacteria: an expanded role for horizontal gene transfer. [PDF]

Microbiology (Reading)
Jones GH.
europepmc   +1 more source

Targeted Restoration of the Microbial Tryptophan Oxidative Pathway Ameliorates Autism‐Like Behavioral and Synaptic Deficits

Advanced Science, EarlyView.
ABSTRACT Autism Spectrum Disorder (ASD) is associated with gut microbiota dysbiosis, yet the contribution of specific microbial metabolic pathways remains unclear. Reanalysis of a public ASD cohort revealed reduced functional potential in microbial tryptophan oxidative metabolism.
Rui Guo, Caian He, Xiao Xiao, Jingmeng Li, Zilong Zhang, Ying He, Chuanchuan Wang, Jiale Zhao, Jun Gong, Jiarui Liang, Tian Yuan, Haiting Sun, Xuebo Liu, Chao Gao, Zhigang Liu   +14 more
wiley   +1 more source

Development of a Loop-Mediated Isothermal Amplification (LAMP) Assay for Rapid Molecular Identification of the Bark Beetle <i>Ips hauseri</i> (Coleoptera: Curculionidae). [PDF]

Insects
Jiao J, Zhang W, Yan L, Zhou Y, Li S, Ren L, Sattar A.   +6 more
europepmc   +1 more source

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source

Complete mitochondrial genome and phylogenetic analysis of Taiwanese Wedgefish (<i>Rhynchobatus immaculatus</i>). [PDF]

Mitochondrial DNA B Resour
Wang S, Zhu X, Zhao L, Liu M.
europepmc   +1 more source

Integrative Multi‐Omics Analysis Reveals a Mitochondrial–Immune Axis Associated With Neoadjuvant Chemotherapy Response in High‐Grade Serous Ovarian Cancer

Advanced Science, EarlyView.
Integrative multi‐omics analysis delineates a mitochondrial–immune axis governing neoadjuvant chemotherapy response in high‐grade serous ovarian cancer. Immune‐active tumors exhibit enhanced B‐cell infiltration and favorable sensitivity, whereas metabolically rewired tumors display oxidative phosphorylation dependency and resistance.
Wei Jiang, Yi Wang, Xiaohang Lu, Qianlan Yao, Libing Xiang, Xu Cai, Xiaoyu Tu, Shaoxian Tang, Ying Xu, Yufan Cheng, Liming Shen, Huijuan Yang   +11 more
wiley   +1 more source

Extreme longevity revealed by 24-year genetic mark-recapture challenges conservation of endangered sea cucumbers. [PDF]

iScience
Uthicke S, Cabrera MG, Byrne M, Purcell SW.   +3 more
europepmc   +1 more source

TOLLIP Inhibits Psoriasis Progression via Suppressing PKM2‐Mediated Glycolysis in Keratinocytes

Advanced Science, EarlyView.
In this study, we identify TOLLIP as a critical regulator of psoriasis pathogenesis through its modulation of glycolytic metabolism. Our findings establish the TOLLIP‐PKM2‐glycolysis axis as a key mechanism linking metabolic reprogramming to psoriasis pathogenesis, and propose TOLLIP as a promising therapeutic target.
Xiuhuan Jiang, Guoying Miao, Na Shen, Qingxia Han, Xiaoru Han, Zichang Qiao, Kexin Feng, Zhuo Tan, Yaguang Wang, Xiuhua Liu, Chen Wu, Zhenzhen Yan   +11 more
wiley   +1 more source

The overlooked conservation values of saline lakes. [PDF]

Nat Commun
Burian A, Wilson R, Kratina P, Ábrám Ö, Afonina E, Alcocer J, Alfonso MB, Anderson T, Anufriieva E, Balci N, Barbosa LG, Baxter BK, Bazarova B, Bazhenov Y, Beckmann M, Boros E, Borzenko S, Bucher EH, Camacho A, Casamayor EO, Chao X, Coleman P, Colla MF, Datson B, Echaniz S, Farias ME, Fetahi T, García CM, Golovatyuk L, Hudson P, Hueso-Kortekaas K, Johnston J, Karimov BK, Kalioujnaia I, Komova A, Krienitz L, Kulshreshtha S, Larson R, Lipka O, Matyugina E, Mauvisseau Q, Melack J, Mills K, Morant D, Moreno E, Namsaraev Z, Oren A, Rogers C, Ryves DB, Sánchez MI, Camacho-Santamans A, Santamans AC, Schagerl M, Selivanova E, Shadrin N, Sima S, Tashlykova N, Teubner K, Tsybekmitova G, Timms B, Ulanova S, Vidal Quini NE, Vignatti A, Wurtsbaugh WA, Zapitis C, Zechmeister T, Zhang C, Zadereev E.   +67 more
europepmc   +1 more source

RNAi in the Rhizarian Phytopathogen Plasmodiophora brassicae: The Causal Agent of Clubroot Disease in Cruciferous Crops

Advanced Science, EarlyView.
This study uncovers an unusual RNAi pathway in the rhizarian pathogen Plasmodiophora brassicae. In the absence of Dicer, a Drosha‐like RNase III protein supports the biogenesis of predominant 21‐nt small RNAs, and two Argonaute proteins mediate small RNA‐guided silencing.
Xiong Zhang, Yupo Wu, Jiachang Hou, Lixia Gao, Longqi Pan, Cuicui Shen, Chuanji Zhao, Feng Gao, Yi Zhang, Li Ren, Xiaoping Fang, Xiaoling Dun, Shengyi Liu, Lijiang Liu   +13 more
wiley   +1 more source