Results 41 to 50 of about 761,695 (308)

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

High sensitive fast gamma radiation sensor based on Yb-doped optical fiber: offline and online detection

JPhys Photonics
Radiation science has a wide range of applications, from industrial uses and medical treatments to space research and national defense. Optical fiber technology offers a flexible and sensitive alternative solution for accurate radiation measurements in ...
Esra Kendir Tekgül, Şerafettin Yaltkaya, Timuçin Emre Tabaru, Bülend Ortaç   +3 more
doaj   +1 more source

Modeling of the second harmonic generation in a lens-shaped InAs/GaAs quantum core/shell dot under temperature, pressure and applied electric field effects

Results in Physics, 2020
In this paper, we explore the second harmonic generation (SHG) in a lens-shaped InAs/GaAs quantum core/shell (LSQCS). The three-dimensional Schrödinger equation is given under the framework of the effective mass approximation and it is solved by using ...
D. Makhlouf, M. Choubani, F. Saidi, H. Maaref   +3 more
doaj   +1 more source

Ultrafast Lasing Dynamics in a CsPbBr3 Perovskite Microplate

Advanced Photonics Research, 2022
The perovskite microlaser is a competitive candidate of light source for optical communication and integrated photonic circuits. Understanding the fundamental mechanism of lasing is crucial for the upcoming devices.
Ju Wang, Haoran Yu, Guodong Liu, Wei Liu, Yiqun Duan, Xue Cheng, Lun Dai, Shufeng Wang, Qihuang Gong   +8 more
doaj   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Protonation states of highly conserved carboxylic acids in NeoR

Biophysics and Physicobiology
Neorhodopsin (NeoR), an enzymerhodopsin, has unique molecular properties. NeoR absorbs near-infrared light whose λmax is located at 690–700 nm. Upon light absorption, NeoR is photoisomerized into the 7-cis form with low quantum yield. Unique color-tuning
Ritsu Mizutori, Masahiro Sugiura, Hideki Kandori   +2 more
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

The Distribution Of Cosmological $\gamma$-ray Bursts

, 1995
We compare the burst distribution of the new (2B) BATSE catalogue to a cosmological distribution. The observed distribution agrees well with a cosmological one, however, it is insensitive to cosmological parameters such as $\O$ and $\Lambda$.
Cohen, Ehud, Piran, Tsvi
core   +1 more source