Results 91 to 100 of about 11,395,794 (316)
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
La red del Comercio Justo y sus principales actores
Investigaciones Geográficas, 2010 Este artículo trata de una descripción concisa del fenómeno del comercio justo y su participación en el comercio mundial. Al mismo tiempo, examina el papel de los diferentes actores que participan en la red del comercio justo, desde los productores hasta
Brisa Ceccon Rocha, Eliane Ceccon
doaj
K-12 public school finance in Missouri: an overview [PDF]
Education ...
Matthew G. Springer, Michael Podgursky
core
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
The state of state and local government finance [PDF]
This paper provides an overview of the state-local government sector, a review of the short-run impact of the 2007-09 recession on state and local governments, and a brief summary of key long-run challenges state and local governments will encounter in ...
Ronald C. Fisher
core
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Enunciación, 2019 Toda investigación tiene como punto de partida el panorama sobre la trayectoria del campo de estudio en la que se inscribe. En la tradición académica se trata de los antecedentes.
Fabio de Jesús Jurado Valencia
doaj
Urban decentralization and income inequality: is sprawl associated with rising income segregation across neighborhoods? [PDF]
Existing research shows an inverse relationship between urban density and the degree of income inequality within metropolitan areas; this information suggests that as urban areas spread out, they become increasingly segregated by income.
Christopher H. Wheeler
core
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source