Results 101 to 110 of about 11,847,356 (302)

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

PB2509: RED BLOOD CELL PYRUVATE KINASE PROPERTIES IN SICKLE CELL DISEASE – OF MICE AND MEN

HemaSphere, 2023
Marissa Traets, Brigitte van Oirschot, Charles Levine, Judith Jans, Minke Rab, Yu-Wei Chen, Richard Van Wijk   +6 more
doaj   +1 more source

Deficiency in red blood cells [PDF]

Nature, 1991
D, MacDonald, M, Town, P, Mason, T, Vulliamy, L, Luzzatto, D K, Goff   +5 more
openaire   +2 more sources

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Immunodeficient mouse model with repeated blood withdrawal and large-volume human platelet transfusion for evaluating hemostatic efficacy of cold-stored platelets

Scientific Reports
Preclinical evaluation of novel platelet products requires an animal model that supports large-volume human platelet transfusion and achieves a high proportion of circulating human platelets. We developed a novel immunodeficient mouse model with repeated
Keita Uchiyama, Masayuki Nogawa, Tomohiko Sato, Yusuke Miyazaki, Rikizo Taira, Shigeki Miyata, Kotaro Kida   +6 more
doaj   +1 more source

Dynamics of neutrophil phenotype and function in sickle cell disease

Frontiers in Immunology
IntroductionWhile sickle cell disease (SCD) is primarily acknowledged as an erythrocyte disorder, emerging evidence suggests a role for altered neutrophil phenotype and function in SCD pathophysiology and disease severity.
Aafke E. Gaartman, Aafke E. Gaartman, Lydian A. de Ligt, Lydian A. de Ligt, Lydian A. de Ligt, Boukje M. Beuger, Anton T. J. Tool, Martijn Veldthuis, Taco W. Kuijpers, Taco W. Kuijpers, Rob van Zwieten, Bart J. Biemond, Robin van Bruggen, Erfan Nur, Erfan Nur   +14 more
doaj   +1 more source

In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols

FEBS Open Bio, EarlyView.
Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton, Fang Zhao, Reeta Davis, Meg Walsh, Kevin E O'Connor, David O'Connell, Tanja Narancic   +6 more
wiley   +1 more source

P717: AG946, A PYRUVATE KINASE (PK) ACTIVATOR IMPROVES PK PROPERTIES AND RED BLOOD CELL (RBC) METABOLISM UPON EX VIVO TREATMENT OF RBCS FROM PATIENTS WITH MYELODYSPLASTIC SYNDROMES

HemaSphere, 2023
Jonathan de Wilde, Titine Ruiter, Brigitte van Oirschot, Judith Jans, Lenny Dang, Megan Wind-Rotolo, Wouter van Solinge, Anna van Rhenen, Richard Van Wijk, Minke Rab   +9 more
doaj   +1 more source

B-cell kinetics in humans: rapid turnover of peripheral blood memory cells.

, 2005
Information about the kinetic behavior and lifespan of lymphocytes is crucial to understanding the mechanisms that regulate processes such as immunologic memory. We have used in vivo labeling of dividing cells with 6,6-(2)H(2)-glucose, combined with cell
Wallace, Diana L, George E. Griffin, Derek C. Macallan, Panayiotakopoulos, George, de Lara, Catherine, Ghattas, Hala, Zhang, Yan, Peter C. L. Beverley, Griffin, George E, Andrew Worth, George Panayiotakopoulos, Macallan, Derek C, Beverley, Peter CL, Tough, David F, Diana L. Wallace, Hala Ghattas, Becca Asquith, Worth, Andrew, David F. Tough, Asquith, Becca, Yan Zhang, Catherine de Lara   +21 more
core   +1 more source