Results 1 to 10 of about 456,023 (269)

Pericentromeric repetitive ncRNA regulates chromatin interaction and inflammatory gene expression

Nucleus, 2022
Cellular senescence provokes a dramatic alteration of chromatin organization and gene expression profile of proinflammatory factors, thereby contributing to various age-related pathologies via the senescence-associated secretory phenotype (SASP ...
Kenichi Miyata, Akiko Takahashi
doaj   +1 more source

A senescent cell bystander effect: senescence‐induced senescence [PDF]

Aging Cell, 2012
SummarySenescent cells produce and secrete various bioactive molecules including interleukins, growth factors, matrix‐degrading enzymes and reactive oxygen species (ROS). Thus, it has been proposed that senescent cells can damage their local environment, and a stimulatory effect on tumour cell growth and invasiveness has been documented.
Nelson G, Wordsworth J, Wang CF, Jurk D, Lawless C, Martin-Ruiz C, von Zglinicki T   +6 more
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Hepatocyte growth factor derived from senescent cells attenuates cell competition-induced apical elimination of oncogenic cells

Nature Communications, 2022
Ras mutations induce cell competition and cellular senescence to inhibit the proliferation of oncogenic mutated cells. Here the authors demonstrate that cellular senescence inhibits cell competition-induced elimination of oncogenic cells through HGF ...
Nanase Igarashi, Kenichi Miyata, Tze Mun Loo, Masatomo Chiba, Aki Hanyu, Mika Nishio, Hiroko Kawasaki, Hao Zheng, Shinya Toyokuni, Shunsuke Kon, Keiji Moriyama, Yasuyuki Fujita, Akiko Takahashi   +12 more
doaj   +1 more source

Telomere Maintenance and the cGAS-STING Pathway in Cancer

Cells, 2022
Cancer cells exhibit the unique characteristics of high proliferation and aberrant DNA damage response, which prevents cancer therapy from effectively eliminating them.
Hiroshi Ebata, Tze Mun Loo, Akiko Takahashi   +2 more
doaj   +1 more source

SENESCENCE AND SENILITY. [PDF]

The Lancet, 1922
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Thompson, R. J. C., Todd, R. E.
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RNaseH2A downregulation drives inflammatory gene expression via genomic DNA fragmentation in senescent and cancer cells

Communications Biology, 2022
Cellular senescence caused by oncogenic stimuli is associated with the development of various age-related pathologies through the senescence-associated secretory phenotype (SASP).
Sho Sugawara, Ryo Okada, Tze Mun Loo, Hisamichi Tanaka, Kenichi Miyata, Masatomo Chiba, Hiroko Kawasaki, Kaoru Katoh, Shizuo Kaji, Yoshiro Maezawa, Koutaro Yokote, Mizuho Nakayama, Masanobu Oshima, Koji Nagao, Chikashi Obuse, Satoshi Nagayama, Keiyo Takubo, Akira Nakanishi, Masato T. Kanemaki, Eiji Hara, Akiko Takahashi   +20 more
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Senescence is not inevitable [PDF]

Biogerontology, 2017
Senescence, the physiological deterioration resulting in an increase in mortality and decline in fertility with age, is widespread in the animal kingdom and has often been regarded as an inescapable feature of all organisms. This essay briefly describes the history of the evolutionary theoretical ideas on senescence. The canonical evolutionary theories
Owen R. Jones, James W. Vaupel
openaire   +3 more sources

The Skin Epilipidome in Stress, Aging, and Inflammation

Frontiers in Endocrinology, 2021
Lipids are highly diverse biomolecules crucial for the formation and function of cellular membranes, for metabolism, and for cellular signaling. In the mammalian skin, lipids additionally serve for the formation of the epidermal barrier and as surface ...
Florian Gruber, Florian Gruber, Florian Gruber, Martina Marchetti-Deschmann, Martina Marchetti-Deschmann, Christopher Kremslehner, Christopher Kremslehner, Christopher Kremslehner, Markus Schosserer, Markus Schosserer, Markus Schosserer   +10 more
doaj   +1 more source

Developmental and age-related changes in apolipoprotein B mRNA editing in mice.

Journal of Lipid Research, 1992
Apolipoprotein B (apoB) mRNA is modified by a post-transcriptional editing reaction (C to U) changing a glutamine (CAA) to a translational stop codon (UAA) and producing apoB-48 mRNA in mammalian liver and intestine. Developmental and age-related changes
K Higuchi, K Kitagawa, K Kogishi, T Takeda   +3 more
doaj   +1 more source

Acts of negotiation: toward a grounded theory of nursing practice in chronic wound care in Austria

BMC Health Services Research, 2023
Background Demographic change and the rise of diabetes mellitus are leading to a projected increase in the prevalence of chronic wounds. People suffering from chronic wounds experience significant losses in their health-related quality of life.
Deborah Drgac, Raffael Himmelsbach
doaj   +1 more source