Results 31 to 40 of about 456,023 (269)

Senescence at a glance

Journal of Cell Science, 2013
Cellular senescence is a stable proliferation arrest that is associated with extensive cellular remodelling and an altered secretory pathway. Through its numerous inducers that lead to altered gene expression, senescence is able to influence many contrasting functions and pathologies, namely tumour suppression, tumour promotion, wound healing and ...
Jeff S, Pawlikowski, Peter D, Adams, David M, Nelson   +2 more
openaire   +3 more sources

Cup‐Like Nuclei Is a Hallmark of DUX4/ERG Acute Lymphoblastic Leukemia and Reveals Cytoplasmic Mitochondria Accumulation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Cup‐like nuclei are a distinctive morphological feature observed in certain cases of acute lymphoblastic leukemia (ALL). We provide evidence that they characterize DUX4/ERG ALL independently of IKZF1 deletion and reveal marked mitochondrial accumulation in this ALL subset.
Chloé Arfeuille, Hugo Roux, Odile Fenneteau, Aurélie Caye‐Eude, Alexia Kinoo, Yoann Vial, André Baruchel, Marion Strullu, Elodie Lainey, Hélène Cavé   +9 more
wiley   +1 more source

Enlarged PML-nuclear bodies trigger conflicting cell cycle signal-mediated cytotoxicity in leukemia cells

Cell Death and Disease
Accumulating evidence suggests that mitogenic signaling during cell cycle arrest can lead to severe cytotoxic outcomes, such as senescence, though the underlying mechanisms remain poorly understood.
Tomohisa Baba, Soichiro Kumamoto, Yuta Moriguchi, Soji Morishita, Atsushi Hirao, Yoshikazu Johmura   +5 more
doaj   +1 more source

Genomic Diversity and Clinical Variability in Pediatric Primary Cutaneous Anaplastic Large Cell Lymphoma: A Case Series

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Primary cutaneous anaplastic large cell lymphoma (pcALCL) is a rare pediatric CD30‐positive T‐cell lymphoproliferative disorder with an excellent prognosis, but its genomic drivers are poorly defined. We report three children with skin‐limited disease demonstrating striking molecular heterogeneity, including NPM::ALK, NUP214::FRK, and a novel ...
Shoshana Greenberger, Efrat Bar‐Ilan, Victoria Marcu, Evgeny Grishin, Rinat Yacobi, Aviv Barzilai, Hana Golan, Assaf Arie Barg   +7 more
wiley   +1 more source

Cellular Senescence: Mechanisms and Therapeutic Potential

Biomedicines, 2021
Cellular senescence is a complex and multistep biological process which cells can undergo in response to different stresses. Referring to a highly stable cell cycle arrest, cellular senescence can influence a multitude of biological processes—both ...
Zehuan Liao, Han Lin Yeo, Siaw Wen Wong, Yan Zhao   +3 more
doaj   +1 more source

The Combined Effect of Obesity and Contraceptive Use on Pulmonary Embolism in Adolescent Females Residing in the United States

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Combined oral contraceptive (COC) use in obese adult women dramatically increases the relative risk of developing a pulmonary embolism (PE). The risk of a PE in obese adolescent females taking contraceptives is currently unknown. The purpose of this investigation was to determine the effect of body mass index (BMI) and contraceptive
John Puetz, Joanne Salas
wiley   +1 more source

Epigenetic Therapies for Acute Myeloid Leukemia and Their Immune-Related Effects

Frontiers in Cell and Developmental Biology, 2019
Over the past decades, our molecular understanding of acute myeloid leukemia (AML) pathogenesis dramatically increased, thanks also to the advent of next-generation sequencing (NGS) technologies.
Valentina Gambacorta, Valentina Gambacorta, Valentina Gambacorta, Daniela Gnani, Luca Vago, Luca Vago, Raffaella Di Micco   +6 more
doaj   +1 more source

Senescence‐based colorectal cancer subtyping reveals distinct molecular characteristics and therapeutic strategies

MedComm, 2023
Cellular senescence has been listed as a hallmark of cancer, but its role in colorectal cancer (CRC) remains unclear. We comprehensively evaluated the transcriptome, genome, digital pathology, and clinical data from multiple datasets of CRC patients and ...
Min‐Yi Lv, Du Cai, Cheng‐Hang Li, Junguo Chen, Guanman Li, Chuling Hu, Baowen Gai, Jiaxin Lei, Ping Lan, Xiaojian Wu, Xiaosheng He, Feng Gao   +11 more
doaj   +1 more source

MicroRNAs and senescence

Aging, 2011
The discovery and analysis of microRNAs (miRNAs) has revealed a new mechanism of gene regulation. miRNAs can base-pair with specific mRNA targets and regulate their expression at the post-transcriptional level [1]. Changes in miRNA abundance are implicated in controlling many biological processes including cellular senescence [2], an irreversible form ...
Ivan, Martinez, Laura L, Almstead, Daniel, DiMaio   +2 more
openaire   +2 more sources

Are Fertility Preservation Procedures Before Gonadotoxic Therapy and Hematopoietic Stem Cell Transplantation Feasible and Safe in Very Young Children? A Retrospective Cohort Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Fertility preservation (FP) is increasingly integrated into the care of pediatric patients exposed to gonadotoxic therapy or conditioning for hematopoietic stem cell transplantation (HSCT), yet perioperative data in infants and toddlers remain scarce.
Kerstin Saalabian, Yannick Braun, Till‐Martin Theilen, Anke Barnbrock, Theresa Rohm, Fabienne Hammant, Nicole Sänger, Aynura Abbasova‐Semiz, Jan‐Henning Klusmann, Thomas Klingebiel, Udo Rolle, Peter Bader, Henning C. Fiegel, Andrea Jarisch   +13 more
wiley   +1 more source