Results 51 to 60 of about 675,022 (305)

Cellular Senescence: Mechanisms and Therapeutic Potential

Biomedicines, 2021
Cellular senescence is a complex and multistep biological process which cells can undergo in response to different stresses. Referring to a highly stable cell cycle arrest, cellular senescence can influence a multitude of biological processes—both ...
Zehuan Liao, Han Lin Yeo, Siaw Wen Wong, Yan Zhao   +3 more
doaj   +1 more source

Clinical Insights Into Hypercalcemia of Malignancy in Childhood

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Hypercalcemia of malignancy (HCM) is a rare but life‐threatening metabolic emergency in children that occurs in less than 1% of pediatric cancer cases, with a reported incidence ranging from 0.4% to 1.0% across different studies. While it is observed in 10%–20% of adult malignancies, pediatric HCM remains relatively uncommon.
Hüseyin Anıl Korkmaz
wiley   +1 more source

In vitro evidence for senescent multinucleated melanocytes as a source for tumor-initiating cells [PDF]

, 2015
Oncogenic signaling in melanocytes results in oncogene-induced senescence (OIS), a stable cell-cycle arrest frequently characterized by a bi- or multinuclear phenotype that is considered as a barrier to cancer progression.
Bröcker, E.-B., Haferkamp, S., Hufnagel, A.L., Kneitz, S., Leikam, C., Meierjohann, S., Murphy, D.J., Mühling, B., Nanda, I., Otto, C., Schartl, M., Schmid, M., Wagner, T.U.   +12 more
core   +5 more sources

Enlarged PML-nuclear bodies trigger conflicting cell cycle signal-mediated cytotoxicity in leukemia cells

Cell Death and Disease
Accumulating evidence suggests that mitogenic signaling during cell cycle arrest can lead to severe cytotoxic outcomes, such as senescence, though the underlying mechanisms remain poorly understood.
Tomohisa Baba, Soichiro Kumamoto, Yuta Moriguchi, Soji Morishita, Atsushi Hirao, Yoshikazu Johmura   +5 more
doaj   +1 more source

Epigenetic Therapies for Acute Myeloid Leukemia and Their Immune-Related Effects

Frontiers in Cell and Developmental Biology, 2019
Over the past decades, our molecular understanding of acute myeloid leukemia (AML) pathogenesis dramatically increased, thanks also to the advent of next-generation sequencing (NGS) technologies.
Valentina Gambacorta, Valentina Gambacorta, Valentina Gambacorta, Daniela Gnani, Luca Vago, Luca Vago, Raffaella Di Micco   +6 more
doaj   +1 more source

Senescence‐based colorectal cancer subtyping reveals distinct molecular characteristics and therapeutic strategies

MedComm, 2023
Cellular senescence has been listed as a hallmark of cancer, but its role in colorectal cancer (CRC) remains unclear. We comprehensively evaluated the transcriptome, genome, digital pathology, and clinical data from multiple datasets of CRC patients and ...
Min‐Yi Lv, Du Cai, Cheng‐Hang Li, Junguo Chen, Guanman Li, Chuling Hu, Baowen Gai, Jiaxin Lei, Ping Lan, Xiaojian Wu, Xiaosheng He, Feng Gao   +11 more
doaj   +1 more source

Cytoplasmic chromatin triggers inflammation in senescence and cancer [PDF]

, 2017
Chromatin is traditionally viewed as a nuclear entity that regulates gene expression and silencing. However, we recently discovered the presence of cytoplasmic chromatin fragments that pinch off from intact nuclei of primary cells during senescence, a ...
Adams, Peter D., Ahasan Al Tanim, K.M., Barber, Glen N., Berger, Shelley L., Capell, Brian C., Dou, Zhixun, Garcia, Benjamin A., Ghosh, Kanad, Jiang, Tianying, Kaestner, Klaus H., Kieckhaefer, Julia E., Lan, Yemin, Lin, Yanping, Millar, Sarah E., Sen, Payel, Seykora, John T., Shoshkes-Carmel, Michal, Simithy, Johayra, Vizioli, Maria Grazia, Wangensteen, Kirk J., Xu, Caiyue, Xu, Mingang, Zhou, Zhuo, Zhu, Jiajun   +23 more
core   +2 more sources

Survival Outcomes and Complications Among Canadian Children With Retinoblastoma: A Population‐Based Report From CYP‐C

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Retinoblastoma (RB) is the most common pediatric ocular cancer, yet population‐based data on survival and risk factors remain limited. This study aimed to describe survival in a large national RB cohort and identify predictors of death and complications.
Samuel Sassine, Ofélie Trudeau‐Ferrin, Caroline Laverdière, Patrick Hamel, Rosanne Superstein, Bénédicte Koukoui, Carole Provost, Paul C. Nathan, Vijay Ramaswamy, Furqan Shaikh, Brenda Gallie, Ashwin Mallipatna, Stephanie Kletke, Helen Dimaras, Hallie Coltin   +14 more
wiley   +1 more source

Lipid and glucose metabolism in senescence

Frontiers in Nutrition, 2023
Senescence is an inevitable biological process. Disturbances in glucose and lipid metabolism are essential features of cellular senescence. Given the important roles of these types of metabolism, we review the evidence for how key metabolic enzymes ...
Bin Liu, Qingfei Meng, Xin Gao, Huihui Sun, Zhixiang Xu, Yishu Wang, Honglan Zhou   +6 more
doaj   +1 more source

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source