Results 51 to 60 of about 542,977 (297)

Epigenetic Therapies for Acute Myeloid Leukemia and Their Immune-Related Effects

Frontiers in Cell and Developmental Biology, 2019
Over the past decades, our molecular understanding of acute myeloid leukemia (AML) pathogenesis dramatically increased, thanks also to the advent of next-generation sequencing (NGS) technologies.
Valentina Gambacorta, Valentina Gambacorta, Valentina Gambacorta, Daniela Gnani, Luca Vago, Luca Vago, Raffaella Di Micco   +6 more
doaj   +1 more source

Lipid and glucose metabolism in senescence

Frontiers in Nutrition, 2023
Senescence is an inevitable biological process. Disturbances in glucose and lipid metabolism are essential features of cellular senescence. Given the important roles of these types of metabolism, we review the evidence for how key metabolic enzymes ...
Bin Liu, Qingfei Meng, Xin Gao, Huihui Sun, Zhixiang Xu, Yishu Wang, Honglan Zhou   +6 more
doaj   +1 more source

Post-Meiotic Intra-Testicular Sperm Senescence in a Wild Vertebrate [PDF]

, 2012
There is growing interest in sperm senescence, both in its underlying mechanisms and evolutionary consequences, because it can impact the evolution of numerous life history traits. Previous studies have documented various types of sperm senescence, but
Richard H. Wagner, Penn, Dustin J., Richard H Wagner, Hoi Herbert, Wagner, Richard H., Hettyey Attila, Hoi, Herbert, Attila Hettyey, Dustin J. Penn, Balázs Vági, Herbert Hoi, Vági Balázs, Wagner Richard H., Penn Dustin J., Hettyey, Attila, Vági, Balázs, Dustin J Penn   +16 more
core   +2 more sources

Provider and Parent Perspectives on Prioritizing the “Asking and Monitoring” Pediatric Cancer Psychosocial Standards of Care

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background The Standards for Psychosocial Care for Children with Cancer and Their Families (“Standards”) are evidence‐based guidelines for psychosocial care in pediatric oncology. Care related to the three “Asking and Monitoring” Standards—Assessment of Psychosocial Needs, Assessment of Financial Needs, and Monitoring Neurocognitive Problems ...
Julia B. Tager, Natalie Koskela‐Staples, Emily M. Pariseau, Michele Scialla, Kimberly Buff, Lori Wiener, Victoria Sardi Brown, Anne E. Kazak, Kimberly S. Canter   +8 more
wiley   +1 more source

Investigating the modulation of long non-coding RNAs associated to senescence using computational and biological approaches [PDF]

, 2022
Senescent cells (SC) are characterized by a distinct change in their morphology and gain of a senescence-associated secretory phenotype (SASP). A complex grid of molecular processes is implicated in the onset of the senescence that is in common also with
Sabrina Briguglio, Cristina Battaglia, Maria Grazia Cattaneo, Flavio Liciulli, Clara Rossi, Marco Venturin, Lisa Giovannelli, Stefano Bellosta, Arianna Consiglio, Giorgio Grillo   +9 more
core   +2 more sources

Combined Bacopa, Phosphatidylserine, and Choline Protect Against Stress-Induced Neurotoxicity

Biomedicines
Background/Objectives: Chronic stress leads to sustained elevations in cortisol levels, which promote neuronal damage and impair memory. Prolonged stress also enhances proinflammatory signaling.
Chiara Sasia, Giacomina Videtta, Nicoletta Galeotti   +2 more
doaj   +1 more source

Does symmetry preclude the evolution of senescence? A comment on Pen & Flatt 2021

, 2022
Patterns of senescence across the tree of life remain poorly understood and a clearly important task is to identify the minimal conditions for senescence to occur at all.
E. Yagmur Erten, Hanna Kokko, Charlotte de Vries   +2 more
core   +1 more source

Safety and Effectiveness of a High‐Dose, Tailored Tissue Plasminogen Activator Therapy Protocol: A Joint Pediatric Hematology and Cardiac ICU Quality Improvement Initiative Analysis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Pediatric thromboembolism is increasingly encountered in critical care. Systemic thrombolysis with tissue plasminogen activator (tPA) facilitates vessel or valve patency, yet pediatric‐specific protocols remain undefined, and safety concerns persist. Objective To evaluate the efficacy and safety of a tailored, prolonged systemic tPA
Eran Shostak, Oded Gilad, Yael Feinstein, Sigal Nakav, Ofer Schiller, Joanne Yacobovich   +5 more
wiley   +1 more source

Camellia japonica Seed Oil Fermented by Sporidiobolus pararoseus Prevents Skin Cellular Photoaging by Inducing Autophagy

Life
Camellia japonica L. (Theaceae) seed oil is an essential component for skin protection, attributed to its antioxidant properties and anti-aging effects. In this study, Camellia japonica seed oil underwent fermentation with Sporidiobolus pararoseus (Fell &
Bai Lv, Jiale Meng, Xichao Zhang, Guangtao Li, Hongqi Gao, Yi Jiang, Zhanwei Zhou, Gang Chen   +7 more
doaj   +1 more source

Neuropsychological and Educational Outcomes in Shwachman–Diamond Syndrome—A Report From the North American Shwachman–Diamond Syndrome Registry

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Shwachman–Diamond syndrome (SDS) is a rare autosomal recessive ribosomopathy characterized by bone marrow failure and multisystem involvement, with emerging evidence of associated neurocognitive impairment. Methods We conducted a retrospective study of 240 individuals with biallelic Shwachman–Bodian–Diamond syndrome (SBDS) mutations
Jane Koo, Melissa Gerstle, Leah Cheng, Richard Cooper, Katherine Coyne, Claire Dusa, Naomi E. Joffe, Diana Schwarz, Sarah Steltz, Akiko Shimamura, Kasiani C. Myers, Thea Quinton   +11 more
wiley   +1 more source