Results 71 to 80 of about 492,919 (268)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

17AAG Treatment Accelerates Doxorubicin Induced Cellular Senescence: Hsp90 Interferes with Enforced Senescence of Tumor Cells.

, 2012
Contains fulltext : 110962.pdf (Publisher’s version ) (Open Access)Hsp90 chaperone has been identified as an attractive pharmacological target to combat cancer.
Sarangi, U., Kumar, J.U., Upasana Sarangi, Amere Subbarao Sreedhar, Paithankar, K.R., Khande Rao Paithankar, Jonnala Ujwal Kumar, Vaidyanathan Subramaniam, Sreedhar, A.S., Subramaniam, V.   +9 more
core   +1 more source

Age-related cellular copper dynamics in the fungal ageing model Podospora anserina and in ageing human fibroblasts [PDF]

, 2009
In previous investigations an impact of cellular copper homeostasis on ageing of the ascomycete Podospora anserina has been demonstrated. Here we provide new data indicating that mitochondria play a major role in this process.
Rittmeyer, Claudia, Olivier Toussaint, Scheckhuber, Christian Q., Ricardo Gredilla, Bernd O Kolbesen, Heinz D, Boilan, Emmanuelle, Claudia Rittmeyer, Gredilla, Ricardo, Christian Q. Scheckhuber, Emmanuelle Boilan, Heinz D. Osiewacz, Debacq-Chainiaux, Florence, Osiewacz, Heinz D., Scheckhuber, Christian Quintus, Christian Q Scheckhuber, Florence Debacq-Chainiaux, Toussaint, Olivier, Kolbesen, Bernd O., Karin Luce, Bernd O. Kolbesen, Heinz D Osiewacz, Grief, Jürgen, Florence Debacq, Jürgen Grief, Luce, Karin   +25 more
core   +1 more source

SAHF, to senesce or not to senesce? [PDF]

Cell Cycle, 2011
Maciej K. Kocylowski, Thanos D. Halazonetis   +1 more
openaire   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Overexpression of a NAC transcription factor delays leaf senescence and increases grain nitrogen concentration in wheat [PDF]

, 2015
Increasing the duration of leaf photosynthesis during grain filling using slow-senescing functional stay-green phenotypes is a possible route for increasing grain yields in wheat (Triticum aestivum L.).
Zhao, D., Derkx, A. P., Buchner, P. H., Hawkesford, M., Hawkesford, M. J., Buchner, P., Liu, D., Liu, D-C., Derkx, A.   +8 more
core   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

The effect of radiation on cellular ageing [PDF]

, 2012
This thesis was submitted for the degree of Master of Philosophy and awarded by Brunel UniversityHumans are exposed to low and moderate doses of ionising radiation (IR) from a range of diagnostic and occupational sources which may lead to cellular ...
Sabin, Rebecca Jane
core