Results 81 to 90 of about 492,919 (268)

A local regulatory network around three NAC transcription factors in stress responses and senescence in Arabidopsis leaves [PDF]

, 2013
A model is presented describing the gene regulatory network surrounding three similar NAC transcription factors that have roles in Arabidopsis leaf senescence and stress responses. ANAC019, ANAC055 and ANAC072 belong to the same clade of NAC domain genes
Cooke, Emma J., Jonathan D. Moore, Laura Bowden, Katherine J. Denby, Hickman, Richard J., Beynon, Jim, Richard Hickman, Findlay Bewicke‐Copley, David L. Wild, Vicky Buchanan‐Wollaston, Jim Beynon, Jackson, Alison C., Denby, Katherine J., Mead, A. (Andrew), Penfold, Christopher A., Bowden, Laura, Andrew Mead, Wild, David L., Christopher A. Penfold, Moore, Jonathan D., Emily Breeze, Breeze, Emily, Alison Jackson, Sascha Ott, Buchanan-Wollaston, Vicky, Peijun Zhang, Emma Cooke, Hill, C., Zhang, Peijun, Bewicke-Copley, Findlay, Claire Hill, Ott, Sascha   +31 more
core   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Role of microRNAs in cellular senescence

, 2011
Senescence is recognized as a permanent arrest of cell proliferation triggered by telomere shortening or various stresses. Senescence imposes a barrier to tumorigenesis and contributes to aging.
FARAONIO, RAFFAELLA
core  

Gibberellin retards chlorophyll degradation during senescence of Paris polyphylla

, 2010
Chlorophyll (Chl) degradation was found to be related to the endogenous gibberellin (GA) content in shoots during senescence in the perennial plant Paris polyphylla var. yunnanensis (Franch.). Treatment with gibberellic acid (GA3) significantly increased
D. Yu, B. Q. Wang, J. R. Wei, J. R. Li, Q. Ma, K. Yu   +5 more
core   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Senescence-associated-β-galactosidase staining following traumatic brain injury in the mouse cerebrum

, 2019
Primary and secondary traumatic brain injury (TBI) can cause tissue damage by inducing cell death pathways including apoptosis, necroptosis, and autophagy. However, similar pathways can also lead to senescence.
Takakazu Kawamata, Tadasuke Tominaga, Kazuhiko Kibayashi (2823470), Tadasuke Tominaga (6444362), Yoshikazu Okada, Kazuhiko Kibayashi, Ryo Shimada (6444365), Ryo Shimada, Yoshikazu Okada (6444368), Takakazu Kawamata (6444371)   +9 more
core   +1 more source

Senescence-associated genes and non-coding RNAs function in pancreatic cancer progression

, 2020
Pancreatic cancer is a major cause of mortality with a poor diagnosis and prognosis that most often occurs in elderly patients. Few studies, however, focus on the interplay of age and pancreatic cancer at the transcriptional level.
Lianbang Zhu (8377356), Ran Zhang (117374), Xuan Ouyang (5259002), Qingyu Cheng (780924), Xiaoyuan Song (8377359)   +4 more
core   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Unravelling the roles of two senescent enhanced MYB transcription factors in the regulation of anthocyanin biosynthesis in Arabidopsis thaliana [PDF]

MYB90 and MYB75 are two MYB transcription factors that regulate anthocyanin biosynthesis in Arabidopsis. Prior to this study a microarray experiment indicated that MYB90 was required for senescence associated anthocyanin biosynthesis.
Warner, Nichola Maxine
core  

In Vitro Investigation of Therapy-Induced Senescence and Senescence Escape in Breast Cancer Cells Using Novel Flow Cytometry-Based Methods

Although cellular senescence was originally defined as an irreversible form of cell cycle arrest, in therapy-induced senescence models, the emergence of proliferative senescence-escaped cancer cells has been reported by several groups, challenging the ...
Moftakhar, Zahra, Tóth, Fanni, Sotgia, Federica, Lisanti, Michael P.   +3 more
core   +1 more source