Results 101 to 110 of about 542,977 (297)
DNA damage-dependent mechanisms of ionizing radiation-induced cellular senescence [PDF]
PeerJCellular senescence can be broadly categorized into replicative senescence and stress-induced premature senescence. Replicative senescence mainly results from the progressive shortening of telomeres during successive cell divisions, eventually leading to
Jiebing Guan +8 more
doaj +2 more sources
Cellular aging in cardiovascular diseases [PDF]
, 2010 As we progress to a society with an increasing average age, the problems that are associated with advanced age becoming more prominent. This is particularly visible by the increase onset of aging associated diseases, such as atherosclerosis, heart ...
Oeseburg, Hisko,, Oeseburg, Hisko
core +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Assessing vascular senescence in zebrafish
, 2012 Zebrafish, a diurnal vertebrate characterized by gradual senescence, is an excellent model for studying age-dependent diseases, such as neurodegenerative diseases.
Ziche, Marina +5 more
core +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Senescence associated markers to evaluate the quality in postharvest of rocket fresh cut leaves
, 2013 Senescence is a degenerative process that inevitably affects the quality and the shelf life of fresh cut leafy vegetables. The occurrence of abiotic stresses during the productive chain as well as inadequate or poor handling practices during harvest ...
H. J. Rogers +5 more
core +2 more sources
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Role of microRNAs in cellular senescence
, 2011 Senescence is recognized as a permanent arrest of cell proliferation triggered by telomere shortening or various stresses. Senescence imposes a barrier to tumorigenesis and contributes to aging.
FARAONIO, RAFFAELLA
core
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source