Results 101 to 110 of about 492,919 (268)
Senescence associated markers to evaluate the quality in postharvest of rocket fresh cut leaves
, 2013 Senescence is a degenerative process that inevitably affects the quality and the shelf life of fresh cut leafy vegetables. The occurrence of abiotic stresses during the productive chain as well as inadequate or poor handling practices during harvest ...
H. J. Rogers +5 more
core
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
The Antisenescence Effect of Trans-Cinnamaldehyde on Adipose-Derived Stem Cells
, 2017 As assuring cell quality is an essential parameter for the success of stem cell therapy, the impact of various senescence-inducing stress signals, and strategies to circumvent them, has been an important area of focus in stem cell research.
Rajamani, Karthyayani;Lin, Yi-Chun;Wen, Tung-Chou;Hsieh, Jeanne;Subeq, Yi-Maun;Liu, Jen-Wei;Lin, Po-Cheng;Harn, Horng-Jyh;Lin, Shinn-Zong;Chiou, Tzyy-Wen
core +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Activating senescence in p16-positive Basal-like breast cancer. [PDF]
, 2016 PhDBreast cancer is the most common cancer in the UK and Basal-like breast cancer (a highly aggressive subtype) accounts for approximately 8-22% of all cases depending on ethnicity.
Moore, Madeleine
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Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
TAp73 promotes anti-senescence-anabolism not proliferation
, 2014 TAp73, a member of the p53 family, has been traditionally considered a tumor suppressor gene, but a recent report has claimed that it can promote cellular proliferation.
Maria Valeria Catani (7651889) +5 more
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Investigating the role of the non-canonical inflammasome in senescence [PDF]
, 2019 Cellular senescence is a permanent proliferative arrest of cells triggered by several different stress mechanisms. Senescent cells display an inflammatory phenotype termed the senescence-associated secretory phenotype (SASP), being IL-1 signalling one
Fernández Duran, Irene
core
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source