Results 11 to 20 of about 675,022 (305)
The emerging role of cellular senescence in renal diseases [PDF]
, 2020 Cellular senescence represents the state of irreversible cell cycle arrest during cell division. Cellular senescence not only plays a role in diverse biological events such as embryogenesis, tissue regeneration and repair, ageing and tumour occurrence ...
Alpini, Gianfranco +12 more
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The Skin Epilipidome in Stress, Aging, and Inflammation
Frontiers in Endocrinology, 2021 Lipids are highly diverse biomolecules crucial for the formation and function of cellular membranes, for metabolism, and for cellular signaling. In the mammalian skin, lipids additionally serve for the formation of the epidermal barrier and as surface ...
Florian Gruber +10 more
doaj +1 more source
Developmental and age-related changes in apolipoprotein B mRNA editing in mice.
Journal of Lipid Research, 1992 Apolipoprotein B (apoB) mRNA is modified by a post-transcriptional editing reaction (C to U) changing a glutamine (CAA) to a translational stop codon (UAA) and producing apoB-48 mRNA in mammalian liver and intestine. Developmental and age-related changes
K Higuchi +3 more
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SWI/SNF regulates a transcriptional programme that induces senescence to prevent liver cancer [PDF]
, 2016 Oncogene-induced senescence (OIS) is a potent tumour suppressor mechanism. To identify senescence regulators relevant to cancer, we screened an shRNA library targeting genes deleted in hepatocellular carcinoma (HCC).
Banito, A +16 more
core +2 more sources
Redox Biology, 2021 The soluble receptor for advanced glycation end-products (sRAGE) has been classically considered a sink for pro-inflammatory RAGE ligands and as such has been associated with protection from inflammatory stress and disease.
Jorge D. Erusalimsky
doaj +1 more source
Acts of negotiation: toward a grounded theory of nursing practice in chronic wound care in Austria
BMC Health Services Research, 2023 Background Demographic change and the rise of diabetes mellitus are leading to a projected increase in the prevalence of chronic wounds. People suffering from chronic wounds experience significant losses in their health-related quality of life.
Deborah Drgac, Raffael Himmelsbach
doaj +1 more source
A chemogenomic screening identifies CK2 as a target for pro-senescence therapy in PTEN-deficient tumours [PDF]
, 2015 Enhancement of cellular senescence in tumours triggers a stable cell growth arrest and activation of an antitumour immune response that can be exploited for cancer therapy.
Alajati, Abdullah +25 more
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Environmental conditions during early life accelerate the rate of senescence in a short-lived passerine bird [PDF]
, 2015 Environmental conditions experienced in early life may shape subsequent phenotypic traits including life history. We investigated how predation risk caused by domestic cats (Felis silvestris catus) and local breeding density affected patterns of ...
Balbontín Arenas, Javier +1 more
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Controlling secretion to limit chemoresistance [PDF]
, 2016 The tumor microenvironment influences cancer progression and therapy outcome by mechanisms not yet fully understood. In this issue, Bent et al. (2016) show how chemotherapy causes endothelial senescence.
Georgilis, A, Gil, J
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Myopathy with Concurrent Tadalafil and Simvastatin
Case Reports in Medicine, 2009 A 48-year-old man, using statin, was admitted to hospital with progressive myalgia after consumption of tadalafil and simvastatin. Muscle pain and penile erection disappeared seven days after interruption of therapy.
Maria Pia Gargante +3 more
doaj +1 more source