Results 11 to 20 of about 492,919 (268)

A senescent cell bystander effect: senescence‐induced senescence [PDF]

Aging Cell, 2012
SummarySenescent cells produce and secrete various bioactive molecules including interleukins, growth factors, matrix‐degrading enzymes and reactive oxygen species (ROS). Thus, it has been proposed that senescent cells can damage their local environment, and a stimulatory effect on tumour cell growth and invasiveness has been documented.
Nelson G, Wordsworth J, Wang CF, Jurk D, Lawless C, Martin-Ruiz C, von Zglinicki T   +6 more
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SENESCENCE AND SENILITY. [PDF]

The Lancet, 1922
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Thompson, R. J. C., Todd, R. E.
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Senescence is not inevitable [PDF]

Biogerontology, 2017
Senescence, the physiological deterioration resulting in an increase in mortality and decline in fertility with age, is widespread in the animal kingdom and has often been regarded as an inescapable feature of all organisms. This essay briefly describes the history of the evolutionary theoretical ideas on senescence. The canonical evolutionary theories
Owen R. Jones, James W. Vaupel
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The transcriptome of Populus in elevated CO2 reveals increased anthocyanin biosynthesis during delayed autumnal senescence [PDF]

, 2010
The delay in autumnal senescence that has occurred in recent decades has been linked to rising temperatures. Here, we suggest that increasing atmospheric CO2 may partly account for delayed autumnal senescence and for the first time, through transcriptome
Tallis, M.J., Street, N.R., Calfapietra, C., Street, N. R., DeAngelis, P., Tallis, Matthew, C. Calfapietra, Street, N., M. J. Tallis, Karnosky, D., Karnosky, D. F., De Angelis, P., Zhang, J., F. Miglietta, G. Taylor, Taylor, G., Tallis, M. J., J. Zhang, N. R. Street, P. De Angelis, Rogers, A., Y. Lin, Lin, Y., Karnosky, D.F., D. F. Karnosky, A. Rogers, Miglietta, F.   +26 more
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The Immortal Senescence [PDF]

, 2016
Activation of oncogenic signaling paradoxically results in the permanent withdrawal from cell cycle and induction of senescence (oncogene-induced senescence (OIS)). OIS is a fail-safe mechanism used by the cells to prevent uncontrolled tumor growth, and, as such, it is considered as the first barrier against cancer.
Anna, Bianchi-Smiraglia, Brittany C, Lipchick, Mikhail A, Nikiforov   +2 more
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Density dependence triggers runaway selection of reduced senescence [PDF]

, 2007
In the presence of exogenous mortality risks, future reproduction by an individual is worth less than present reproduction to its fitness. Senescent aging thus results inevitably from transferring net fertility into younger ages.
Doncaster, C. Patrick, Robert M Seymour, C. Patrick Doncaster, Seymour, RM, C Patrick Doncaster, Seymour, Robert M., Doncaster, CP, Robert M. Seymour   +7 more
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ATM in senescence

Oncotarget, 2015
Senescence is a state of stable cell growth arrest that can be triggered by multiple stressors, including oncogene activation [1]. In normal diploid mammalian cells, activation of oncogenes such as oncogenic RAS or BRAF decreases dNTP levels, which leads to replication stress and ultimately senescence [2].
Katherine M, Aird, Rugang, Zhang
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A specific group of genes respond to cold dehydration stress in cut Alstroemeria flowers whereas ambient dehydration stress accelerates developmental senescence expression patterns [PDF]

, 2010
Petal development and senescence entails a normally irreversible process. It starts with petal expansion and pigment production, and ends with nutrient remobilization and ultimately cell death.
Rogers, H., Thornber, Sarah, Thornber, Sarah Elizabeth, Irene Bramke, Bramke, I., Tony Stead, Rogers, Hilary Joan, Vicky Buchanan-Wollaston, Thornber, S., Stead, T., Elizabeth Harrison, Rogers, Hilary, Breeze, E., Wagstaff, Carol, Bramke, Irene, Brian Thomas, Carol Wagstaff, Emily Breeze, Breeze, Emily, Harrison, Elizabeth, Buchanan-Wollaston, V., Thomas, Bryan, Sarah Thornber, Stead, Tony, Buchanan-Wollaston, Vicky, Hilary Rogers, Thomas, B., Thomas, Brian, Harrison, E.   +28 more
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Hormonal changes during salinity-induced leaf senescence in tomato (Solanum lycopersicum L.) [PDF]

, 2008
Leaf senescence is one of the most limiting factors to plant productivity under salinity. Both the accumulation of specific toxic ions (e.g. Na+) and changes in leaf hormone relations are involved in the regulation of this process. Tomato plants (Solanum
Lutts, S., Pérez-Alfocea, Francisco, Lutts, Stanley, Romero-Aranda, Remedios, Martínez-Andújar, Cristina, Acosta, Manuel, Ghanem, M. E., Ghanem, Michel Edmond, Albacete, Alfonso, Romero-Aranda, M. Remedios, Dodd, Ian C.   +10 more
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Senescence and Cancer [PDF]

Cancer Translational Medicine, 2018
Senescence is a double-edged sword that can function in opposite directions. It is a potential mechanism for a cell to avoid malignant transformation. However, senescence can also promote cancer development by altering the cellular microenvironment through a senescence-associated secretory phenotype (SASP). At least, three types of cellular stress such
Sulin, Zeng, Wen H, Shen, Li, Liu
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