Results 21 to 30 of about 479,194 (269)

Molecular Mechanisms of Alveolar Epithelial Stem Cell Senescence and Senescence-Associated Differentiation Disorders in Pulmonary Fibrosis

open access: yesCells, 2022
Pulmonary senescence is accelerated by unresolved DNA damage response, underpinning susceptibility to pulmonary fibrosis. Recently it was reported that the SARS-Cov-2 viral infection induces acute pulmonary epithelial senescence followed by fibrosis ...
Xiaojing Hong   +4 more
doaj   +1 more source

Wheat leaf senescence and its regulatory gene network

open access: yesCrop Journal, 2021
Wheat leaf senescence is a developmental process that involves expressional changes in thousands of genes that ultimately impact grain protein content (GPC), grain yield (GY), and nitrogen use efficiency.
Nigarin Sultana   +3 more
doaj   +1 more source

Cellular Senescence

open access: yesAnnals of Medicine, 1992
The ageing of cells, cellular senescence, is an event that is encountered in all normal cells. Cells grown in vitro have a limited life span and do not grow well after a certain number of divisions. They cease to divide and eventually die. In accordance with this, the life expectancy of an established cell culture depends on the age of the donor. Cells
K, Koli, J, Keski-Oja
openaire   +2 more sources

Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney diseaseResearch in context

open access: yesEBioMedicine, 2019
Background: Senescent cells, which can release factors that cause inflammation and dysfunction, the senescence-associated secretory phenotype (SASP), accumulate with ageing and at etiological sites in multiple chronic diseases.
LaTonya J. Hickson   +32 more
doaj   +1 more source

Senescence and Cancer [PDF]

open access: yesCancer Translational Medicine, 2018
Senescence is a double-edged sword that can function in opposite directions. It is a potential mechanism for a cell to avoid malignant transformation. However, senescence can also promote cancer development by altering the cellular microenvironment through a senescence-associated secretory phenotype (SASP). At least, three types of cellular stress such
Sulin, Zeng, Wen H, Shen, Li, Liu
openaire   +2 more sources

Capturing and Selecting Senescence Variation in Wheat

open access: yesFrontiers in Plant Science, 2021
Senescence is a highly quantitative trait, but in wheat the genetics underpinning senescence regulation remain relatively unknown. To select senescence variation and ultimately identify novel genetic regulators, accurate characterization of senescence ...
Elizabeth A. Chapman   +3 more
doaj   +1 more source

Folate levels in hepatocellular carcinoma patients with portal vein thrombosis

open access: yesBMC Gastroenterology, 2020
Background Portal vein thrombosis (PVT) occurs frequently in hepatocellular carcinoma (HCC) and is often diagnosed in the course of a routine patient evaluation and surveillance for liver cancer.
Giulia Malaguarnera   +7 more
doaj   +1 more source

THE KINETICS OF SENESCENCE [PDF]

open access: yesJournal of General Physiology, 1924
The course of decline of vitality with age due to the process of senescence, when not complicated by the process of growth, follows a simple exponential law; that is the degree of vitality or of senescence (defining vitality as the reciprocal of senescence) at any moment is, regardless of age, a constant percentage of the degree of vitality or ...
openaire   +2 more sources

Resveratrol in Autism Spectrum Disorders: Behavioral and Molecular Effects

open access: yesAntioxidants, 2020
Resveratrol (RSV) is a polyphenolic stillbenoid with significant anti-oxidative and anti-inflammatory properties recently tested in animal models of several neurological diseases.
Michele Malaguarnera   +2 more
doaj   +1 more source

Transcriptional Programs and Regulators Underlying Age-Dependent and Dark-Induced Senescence in Medicago truncatula

open access: yesCells, 2022
In forage crops, age-dependent and stress-induced senescence reduces forage yield and quality. Therefore, delaying leaf senescence may be a way to improve forage yield and quality as well as plant resilience to stresses.
Kashif Mahmood   +4 more
doaj   +1 more source

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