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Advanced Healthcare Materials, EarlyView.Schematic illustration of the mechanism of targeted delivery of nanoparticles including 1) paracellular, 2) endolysosomal escape, 3) receptor mediated endocytosis, and 4) M cell mediated transport for non‐GI diseases by oral administration such as atherosclerosis, cancer, diabetes, and brain diseases. Abstract Oral drug delivery is a promising approach
Subarna Ray +2 more
wiley +1 more source
Advanced Healthcare Materials, EarlyView.Deinococcus radiodurans‐derived extracellular vesicles (R1‐EVs) provide radioprotection against total‐body irradiation‐induced acute radiation syndrome in mice. R1‐EVs mitigate oxidative damage by scavenging free radicals, promoting intestinal repair, enhancing hematopoietic function, and modulating immune responses. This study highlights the potential
Jeong Moo Han +7 more
wiley +1 more source
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Red‐blood‐cell alloimmunization and number of red‐blood‐cell transfusions
Vox Sanguinis, 2011Background Patients receiving red‐blood‐cells may form antibodies against the alloantigens expressed by red‐blood‐cells, with the risk of serious morbidity and the need for extensive phenotype‐matching in subsequent transfusions. The incidence of alloimmunization is considered variable for specific patient groups and for first time antibody formation.
Zalpuri, S. +5 more
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The International Journal of Biochemistry & Cell Biology, 2002
Red blood cells are derived from haemopoietic stem cells in bone marrow. Following a series of maturation steps, directed largely by the hormone erythropoietin (Epo), red cells enucleate and enter the circulatory system. In circulation these small, flexible biconcave cells containing haemoglobin transport O(2) from the lungs to the periphery, and CO(2)
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Red blood cells are derived from haemopoietic stem cells in bone marrow. Following a series of maturation steps, directed largely by the hormone erythropoietin (Epo), red cells enucleate and enter the circulatory system. In circulation these small, flexible biconcave cells containing haemoglobin transport O(2) from the lungs to the periphery, and CO(2)
openaire +3 more sources
Artificial Cells, Blood Substitutes, and Biotechnology, 1998
Soluble polymerized haemoglobin (polyhaemoglobin) is now in a phase III clinical trials. Patients have received up to 20 units (10 litres) in trauma surgery and other surgery. Polyhaemoglobin can be stored for more than 1 year. Haemoglobin solutions have no blood group antigen and can be used as a 'universal donor' oxygen carrier.
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Soluble polymerized haemoglobin (polyhaemoglobin) is now in a phase III clinical trials. Patients have received up to 20 units (10 litres) in trauma surgery and other surgery. Polyhaemoglobin can be stored for more than 1 year. Haemoglobin solutions have no blood group antigen and can be used as a 'universal donor' oxygen carrier.
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Survey of Anesthesiology, 1969
AS an essential therapeutic agent in modern medical practice, human blood is clearly a valuable and limited natural resource. The total use of blood grows annually, as does the difficulty of procuring it in amounts sufficient to meet expanding needs.
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AS an essential therapeutic agent in modern medical practice, human blood is clearly a valuable and limited natural resource. The total use of blood grows annually, as does the difficulty of procuring it in amounts sufficient to meet expanding needs.
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Transfusion Clinique et Biologique, 2010
Since its discovery in the 17th century, the red blood cell, recognized in time as the critical cell component for survival, has been the focus of much attention. Its unique role in gas exchange (oxygen/CO(2) transport) and its distinct characteristics (absence of nucleus; biconcave cell shape) together with an - in essence - unlimited supply lead to ...
Alan W. Thomas +2 more
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Since its discovery in the 17th century, the red blood cell, recognized in time as the critical cell component for survival, has been the focus of much attention. Its unique role in gas exchange (oxygen/CO(2) transport) and its distinct characteristics (absence of nucleus; biconcave cell shape) together with an - in essence - unlimited supply lead to ...
Alan W. Thomas +2 more
openaire +3 more sources
Cryopreservation of red blood cells
Vox Sanguinis, 1994“There is practically no mention in the literature of attempts to keep red blood cells alive in vitro, yet methods for their preservation might have much practical importance, and certainly would possess theoretical interest. Kept cells could be utilized for serum reactions or for transfusion.
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1993
Clinical psychophysiology requires competence in many therapeutic skills, including assessment of physical, mental, affective, and emotional states; biofeedback; and psychotherapy, which we may perform as strict behaviorists, cognitivists, or both. If we are physiologists, we tend to see the mind embedded in brain neurons; if mentalists, we believe a ...
Robert Fried, Joseph Grimaldi
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Clinical psychophysiology requires competence in many therapeutic skills, including assessment of physical, mental, affective, and emotional states; biofeedback; and psychotherapy, which we may perform as strict behaviorists, cognitivists, or both. If we are physiologists, we tend to see the mind embedded in brain neurons; if mentalists, we believe a ...
Robert Fried, Joseph Grimaldi
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Clinics in Laboratory Medicine, 2021
Red blood cell (RBC) transfusions are necessary to increase a patient's oxygen carrying capacity. The optimal transfusion trigger remains elusive, but a restrictive transfusion trigger of 7 g/dL has been shown in studies to reduce RBC transfusions without adversely affecting patient outcomes.
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Red blood cell (RBC) transfusions are necessary to increase a patient's oxygen carrying capacity. The optimal transfusion trigger remains elusive, but a restrictive transfusion trigger of 7 g/dL has been shown in studies to reduce RBC transfusions without adversely affecting patient outcomes.
openaire +2 more sources