Results 51 to 60 of about 11,847,356 (302)

Optimisation of the Danish national haemoglobinopathy screening programme – A prospective intervention study

eJHaem
Introduction The Danish national haemoglobinopathy screening programme offers screening to at‐risk pregnant women. Despite efforts to increase awareness of the screening programme, most women in the target population remain unscreened. In contrast, > 90%
Esther Agnethe Ejskjær Gravholt, Finn Stener Jørgensen, Charlotte Holm, Jesper Petersen, Amina Nardo‐Marino, Mathis Mottelson, Andreas Glenthøj   +6 more
doaj   +1 more source

Large-Scale Expansion of Suspension Cells in an Automated Hollow-Fiber Perfusion Bioreactor

Bioengineering
Bioreactors enable scalable cell cultivation by providing controlled environments for temperature, oxygen, and nutrient regulation, maintaining viability and enhancing expansion efficiency.
Eric Bräuchle, Maria Knaub, Laura Weigand, Elisabeth Ehrend, Patricia Manns, Antje Kremer, Hugo Fabre, Halvard Bonig   +7 more
doaj   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

Correction: Bräuchle et al. Large-Scale Expansion of Suspension Cells in an Automated Hollow-Fiber Perfusion Bioreactor. Bioengineering 2025, 12, 644

Bioengineering
In the original publication [...]
Eric Bräuchle, Maria Knaub, Laura Weigand, Elisabeth Ehrend, Patricia Manns, Antje Kremer, Hugo Fabre, Halvard Bonig   +7 more
doaj   +1 more source

Meta-Analysis of Genome-Wide Association and Gene Expression Studies Implicates Donor T Cell Function and Cytokine Pathways in Acute GvHD

Frontiers in Immunology, 2020
Graft-vs.-host disease (GvHD) is a major complication after allogeneic hematopoietic stem cell transplantation that causes mortality and severe morbidity.
Kati Hyvärinen, Satu Koskela, Riitta Niittyvuopio, Anne Nihtinen, Liisa Volin, Urpu Salmenniemi, Mervi Putkonen, Ismael Buño, David Gallardo, Maija Itälä-Remes, Jukka Partanen, Jarmo Ritari   +11 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

A pilot clinical phase II trial MemSID: Acute and durable changes of red blood cells of sickle cell disease patients on memantine treatment

eJHaem, 2020
An increase in abundance and activity of N‐methyl D‐aspartate receptors (NMDAR) was previously reported for red blood cells (RBCs) of sickle cell disease (SCD) patients. Increased Ca2+ uptake through the receptor supported dehydration and RBC damage.
Asya Mahkro, Inga Hegemann, Elena Seiler, Greta Simionato, Viviana Claveria, Nikolay Bogdanov, Clelia Sasselli, Paul Torgerson, Lars Kaestner, Markus G. Manz, Jeroen S. Goede, Max Gassmann, Anna Bogdanova   +12 more
doaj   +1 more source

THE INSTABILITY OF RED BLOOD CELLS [PDF]

The Lancet, 1919
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openaire   +2 more sources

Effects of Blood Transfusion Sets on Red Blood Cell Hemolysis

, 2019
This experimental randomized study compared the effects of macrodrop and microdrop blood transfusion sets on red blood cell (RBC) hemolysis. Twenty units of packed RBCs from different donors were infused through 48 infusion sets from 2 manufacturers at ...
Pardo, LP, Pires, MPDO, Peterlini, MAS, Kusahara, DM, Pedreira, MLG, Avelar, AFMH, Nani, LAS, Maria Paula de Oliveira Pires, Mavilde Luz Gonçalves Pedreira, Maria Angélica Sorgini Peterlini, Luiz Augusto Silva Nani, Larissa Perez Pardo, Ariane Ferreira Machado Avelar, Denise Miyuki Kusahara   +13 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source