Results 91 to 100 of about 233,459 (268)

The Complexity of Genotype-Phenotype Correlations in Hereditary Spherocytosis: A Cohort of 95 Patients

HemaSphere, 2019
. Hereditary spherocytosis (HS) is a phenotypically and genetically heterogeneous disease. With the increased use of Next Generation Sequencing (NGS) techniques in the diagnosis of red blood cell disorders, the list of unique pathogenic mutations ...
Annelies van Vuren, Bert van der Zwaag, Rick Huisjes, Nathalie Lak, Marc Bierings, Egbert Gerritsen, Eduard van Beers, Marije Bartels, Richard van Wijk   +8 more
doaj   +1 more source

Shape Memory Polymer‐Based Flexible Pressure Sensor for Real‐Time Venous Thrombosis Monitoring

Advanced Materials Interfaces, EarlyView.
A shape‐memory tubular flexible pressure sensor with a 100‐mesh microstructured SMP‐PLA/MWCNTs sensing layer was developed for PICC‐mounted monitoring of thrombosis‐related pressure changes. The sensor combines high sensitivity (204 kPa−1), a fast response time (28 ms), and conformal catheter fixation and was validated by hydrostatic and ex vivo ...
Yi Chen, Mengtao Huang, Ang Wang, Linsen Tang, Mengting He, Xuejin Li, Shaoxing Qu, Zongrong Wang   +7 more
wiley   +1 more source

Additive‐Manufactured, Multifunctional Bioreactor Technology for Dynamic Culture of 3D Bioprinted Tissue Models

Advanced Materials Technologies, EarlyView.
We introduce an additively manufactured bioreactor with a perfusion flow system and integrated temperature and pH sensors for skeletal muscle tissue biofabrication. The bioreactor's performance was evaluated by assessing the viability, spreading of the myoblast cells in a printed scaffold, and contraction of the isolated murine musculi interossei ...
Lys Sprenger, Johann Schorzmann, Hsuan‐Heng Lu, Muhammad Osama, Julian Bauer, Michael Haug, Oliver Friedrich, Aldo R. Boccaccini, Frank Döpper, Sahar Salehi   +9 more
wiley   +1 more source

Red Blood Cell Aging as a Homeostatic Response to Exercise-Induced Stress

Applied Sciences, 2019
Our knowledge on the molecular mechanisms of red blood cell aging is mostly derived from in vitro studies. The Four Days Marches of Nijmegen in the Netherlands, the world’s largest yearly walking event, constitutes a unique possibility to study the
Joames K. Freitas Leal, Dan Lazari, Coen C.W.G. Bongers, Maria T.E. Hopman, Roland Brock, Giel J.C.G.M. Bosman   +5 more
doaj   +1 more source

Flexible Implantable Silicon Carbide Multi‐Electrode Array (MEA) for Cell Multichannel Recording and Cell Ablation

Advanced Materials Technologies, EarlyView.
Flexible silicon carbide (SiC) microelectrode arrays enable high‐fidelity, multichannel cell extracellular recording and precise localized ablation. SiC has been extensively evaluated to persist long‐term in chronic physiological conditions while remaining robust, with excellent electrical and electrochemical stability.
Minh Anh Huynh, Matthew Barton, Sharda Yadav, Tuan‐Khoa Nguyen, Nam‐Trung Nguyen   +4 more
wiley   +1 more source

Biophysical profiling of red blood cells from thin-film blood smears using deep learning

Heliyon
Microscopic inspection of thin-film blood smears is widely used to identify red blood cell (RBC) pathologies, including malaria parasitism and hemoglobinopathies, such as sickle cell disease and thalassemia.
Erik S. Lamoureux, You Cheng, Emel Islamzada, Kerryn Matthews, Simon P. Duffy, Hongshen Ma   +5 more
doaj   +1 more source

Red Blood Cell Homeostasis: pharmacological interventions to explore biochemical, morphological and mechanical properties

Frontiers in Molecular Biosciences, 2016
During their passage through the circulation, red blood cells (RBCs) encounter severe physiological conditions consisting of mechanical stress, oxidative damage and fast changes in ionic and osmotic conditions.
Judith eCluitmans, Federica eGevi, Angela eSiciliano, Alessandro eMatte, Joames eFreitas Leal, Lucia eDe Franceschi, Lello eZolla, Roland eBrock, Merel eAdjobo-Hermans, Giel eBosman   +9 more
doaj   +1 more source

An Imaging‐Guided, Patient‐Specific Guiding Aid (RWNGuide) for Safe and Reproducible Inner Ear Drug Delivery

Advanced Materials Technologies, EarlyView.
A patient‐specific, imaging‐guided aid enables precise and reproducible drug delivery to the inner ear. By guiding therapeutic agents directly to the round window niche, this approach reduces variability in drug localization, improves delivery safety, and addresses a critical bottleneck in inner ear therapy, offering a scalable strategy for precision ...
Yanjing Luo, Shanshan Jiang, Yimian Luo, Adele Moatti, Farnaz Matin‐Mann   +4 more
wiley   +1 more source

Microneedles Mediated Delivery of Nanodiamonds for Quantum Sensing of Free Radicals in Skin Tissue

Advanced Materials Technologies, EarlyView.
Fluorescent nanodiamonds are nanoscale sensors capable of monitoring cellular stress responses. However, to function effectively, they must be delivered into cells or tissues. Here, we demonstrate their application in the skin by developing a dissolvable microneedle platform that dissolves after skin insertion, enabling the delivery of nanodiamonds ...
Siyu Fan, Maria Carmona Lobita, Thea Vedelaar, Yue Zhang, Claudia Reyes‐San‐Martin, Tomás Bauleth‐Ramos, Gésinda Geertsema‐Doornbusch, Han Gao, Mohammad‐Ali Shahbazi, Hélder A. Santos, Romana Schirhagl   +10 more
wiley   +1 more source

Disturbed Red Blood Cell Structure and Function: An Exploration of the Role of Red Blood Cells in Neurodegeneration

Frontiers in Medicine, 2018
The structure of red blood cells is affected by many inborn and acquired factors, but in most cases this does not seem to affect their function or survival in physiological conditions.
Giel J. C. G. M. Bosman
doaj   +1 more source