Results 41 to 50 of about 1,060,576 (279)

Red blood cell “aggregability”

Clinical Hemorheology and Microcirculation, 2009
It is well understood that the extent of red blood cell (RBC) aggregation is determined by both plasmatic and cellular factors [10]. It is also clear that alterations of plasmatic and cellular factors may be related to separate disease processes [1]. For example, plasma composition may change (e.g., fibrinogen concentration increase) due to an acute ...
Herbert J. Meiselman, Oguz K. Baskurt
openaire   +4 more sources

The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1

FEBS Letters, EarlyView.
MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson, Robert Gustafsson Westergren, Ingrid Almlöf, Ann‐Sofie Jemth, Martin Scobie, Ulrika Warpman Berglund, Thomas Helleday, Pål Stenmark   +7 more
wiley   +1 more source

Exploration of the relationship between the storage time of leukodepleted red blood cell and transfusion adverse reactions

Zhongguo shuxue zazhi, 2023
Objective To explore the relationship between the storage time of leukodepleted red blood cells and transfusion adverse reactions by analyzing the occurrence of transfusion adverse reactions of patients after leukodepleted red blood cells transfusion ...
Liu HE, Jian LIU, Gang WU, En WANG, Fayan YI, Xingshun TAN, Shiyu ZHU, Rui YU, Guanghui LU, Yan LIU, Mei ZHAI, Qing XIANG, Ping LIU, Yanhua LIAO, Zhizhen FU, Maolin LI, Rong HUANG   +16 more
doaj   +1 more source

Red blood cells in thrombosis [PDF]

Blood, 2017
Abstract Red blood cells (RBCs) have historically been considered passive bystanders in thrombosis. However, clinical and epidemiological studies have associated quantitative and qualitative abnormalities in RBCs, including altered hematocrit, sickle cell disease, thalassemia, hemolytic anemias, and malaria, with both arterial and venous
James R. Byrnes, Alisa S. Wolberg
openaire   +3 more sources

Neutrophil deficiency increases T cell numbers at the site of tissue injury in mice

FEBS Letters, EarlyView.
In wild‐type mice, injury or acute inflammation induces neutrophil influx followed by macrophage accumulation. Mcl1ΔMyelo (neutrophil‐deficient) mice lack neutrophils, and in response to muscle injury show fewer macrophages and exhibit strikingly elevated T‐cell numbers, primarily non‐conventional “double‐negative” (DN) αβ and γδ T cells.
Hajnalka Halász, Albert Bálint Papp, Lukács Sándor Lesinszki, Attila Mócsai, Tamás Varga, László Nagy, Péter Gogolák   +6 more
wiley   +1 more source

Aplikasi self-organizing mapping sebagai alat deteksi anemia pada citra sel darah merah

Jurnal Gizi Klinik Indonesia, 2019
Application of self-organizing mapping as anemia detection using an image of red blood cells Background: Anemia is a nutritional problem characterized by changes in blood cell size, especially in microcytic or macrocytic anemia.
Evrita Lusiana Utari, Latifah Listyalina, Desty Ervira Puspaningtyas   +2 more
doaj   +1 more source

Recent advances in perioperative blood management

Indian Journal of Anaesthesia, 2023
Transfusion of blood and blood products has many adverse effects and should be done only if patient benefits outweigh the associated risks. Current understanding of blood transfusion has improved dramatically, revolutionising the care of surgical, trauma,
Handattu M Krishna, Mukesh Kumar Prasad, Milon V Mitragotri, G I Bipin, Divya Gupta, Ridhima Sharma   +5 more
doaj   +1 more source

Ergothioneine supplementation improves pup phenotype and survival in a murine model of spinal muscular atrophy

FEBS Letters, EarlyView.
Spinal muscular atrophy (SMA) is a genetic disease affecting motor neurons. Individuals with SMA experience mitochondrial dysfunction and oxidative stress. The aim of the study was to investigate the effect of an antioxidant and neuroprotective substance, ergothioneine (ERGO), on an SMNΔ7 mouse model of SMA.
Francesca Cadile, Daniela Ratto, Giorgia Rastelli, Ottavia Eleonora Ferraro, Caterina Temporini, Sunil Kumar, Simona Boncompagni, Paola Rossi, Monica Canepari   +8 more
wiley   +1 more source

THE AGGLUTINATION OF RED BLOOD CELLS [PDF]

Journal of General Physiology, 1924
1. Unsensitized sheep cells suspended in sugar solutions are agglutinated by electrolytes whenever the potential is depressed to 6 millivolts or less, except in the case of MgCl2 or CaCl2. 2. With these salts no agglutination occurs although there is practically no potential. The presence of these salts prevents acid agglutination.
John H. Northrop, Jules Freund
openaire   +3 more sources

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

Molecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin, Audrey Vinchent, Marie Fernandes, Isabelle Damour, Agathe Laratte, Rémi Tellier, Gabriella O. Estevam, Jean‐Pascal Meneboo, Céline Villenet, Clotilde Descarpentries, James S. Fraser, Martin Figeac, Alexis B. Cortot, Etienne Rouleau, David Tulasne   +14 more
wiley   +1 more source