Results 51 to 60 of about 10,577,810 (295)
Reversible regulation of γ-globin expression by LRF through a BCL11A-independent mechanism
Blood Red Cells & Iron: Leukemia/lymphoma-related factor (LRF; encoded by ZBTB7A ) is a key repressor of γ-globin expression that functions with BCL11A through recruitment of the nucleosome remodeling and deacetylase (NuRD) complex.
Manaka Miyazaki +9 more
doaj +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
In silico postscreening study of antisickling agents to treat sickle cell disease
Blood Red Cells & Iron: Sickle cell disease (SCD) affects ∼100 000 people in the United States and millions worldwide. Although curative therapies exist, their application is limited by cost and donor availability, making drug therapy the most accessible option for most ...
Ying Qian +7 more
doaj +1 more source
A novel method to count the red blood cells in thin blood films
, 2011 This paper describes a novel idea to identify the total number of red blood cells (RBCs) as well as their location in a Giemsa stained thin blood film image.
Morling, R.C.S. +3 more
core +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Blood Red Cells & Iron: Acute anemia is a medical emergency that impairs oxygen delivery to tissues and organs in patients and is usually treated with red blood cell transfusion.
Danielle Olonoff +4 more
doaj +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Blood Red Cells & Iron: Hepcidin is the central hormonal regulator of systemic iron homeostasis and a critical mediator and biomarker of iron disorders. Extensive basic and clinical studies have clarified hepcidin’s role in controlling dietary iron absorption, iron recycling ...
Elizabeta Nemeth, Tomas Ganz
doaj +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Blood Red Cells & Iron: Diamond-Blackfan anemia (DBA) is an inherited anemia characterized by ribosome defects that reduce globin chain production, producing an excess of toxic heme.
David J. Young +8 more
doaj +1 more source