Results 71 to 80 of about 10,577,810 (295)
Blood Red Cells & Iron: Sialic acid-binding immunoglobulin-like lectin-9 (Siglec-9) is a neutrophil inhibitory receptor. Prior studies have shown that sickle red blood cells (SS RBCs) abnormally engage neutrophil Siglec-9, suggesting that SS RBCs may not be able to ...
Grace M. Lee +4 more
doaj +1 more source
Red Blood Cells: Chasing Interactions
Frontiers in Physiology, 2019 Human red blood cells (RBC) are highly differentiated cells that have lost all organelles and most intracellular machineries during their maturation process.
Virginia Pretini +8 more
doaj +1 more source
A guideline for transfusion of red blood cells in surgical patients
, 2000 Blood transfusion carries a real but unquantifiable risk of adverse outcome in surgical patients from infectious, immunological and cardiorespiratory morbid events.
National Blood Users Group
core
Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source
PIEZO1-driven echinocytosis in red blood cells is independent of calcium and water fluxes
Blood Red Cells & Iron: In red blood cells (RBCs), activation of the mechanosensitive channel PIEZO1 is traditionally thought to induce a large Ca 2+ influx, leading to activation of the Gárdos channel (KCNN4), cell dehydration, and echinocytosis.
Pamela Aza-Gnandji +4 more
doaj +1 more source
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Pyruvate kinase activators in the context of erythropoiesis defects
Blood Red Cells & Iron: Pyruvate kinase activators are a promising class of small molecules that boost glycolytic flux and influence cellular energy metabolism. This review covers the development of pyruvate kinase activation as a therapeutic strategy and its impact on ...
Kevin H. M. Kuo +2 more
doaj +1 more source
Superior survival of ex vivo cultured human reticulocytes following transfusion into mice
Haematologica, 2017 The generation of cultured red blood cells from stem cell sources may fill an unmet clinical need for transfusion-dependent patients, particularly in countries that lack a sufficient and safe blood supply.
Sabine Kupzig +4 more
doaj +1 more source
Molecular Oncology, EarlyView.We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth +17 more
wiley +1 more source
Diagnosis, management, and outcomes of tumor-associated erythrocytosis
Blood Red Cells & Iron: Secondary erythrocytosis (SE) refers to elevated hemoglobin (>160 g/L in females; >165 g/L in males) not because of an underlying myeloproliferative neoplasm. Tumor-associated erythrocytosis (TAE) is a rare cause of SE, with limited data on tumor types,
Sara Sadeghi +5 more
doaj +1 more source