Results 91 to 100 of about 1,224,953 (315)

Lineage tracing of Pf4-Cre marks hematopoietic stem cells and their progeny [PDF]

, 2012
The development of a megakaryocyte lineage specific Cre deleter, using the Pf4 (CXCL4) promoter (Pf4-Cre), was a significant step forward in the specific analysis of platelet and megakaryocyte cell biology.
Calaminus, Simon, Watson, Steve P., Tessa L. Holyoake, Guitart, Amelie V., Amelie V Guitart, Calaminus, Simon D J, Machesky, Laura, Schachtner, Hannah, Steve P Watson, Amelie V. Guitart, Amy Sinclair, Amelie Guitart, Kranc, Kamil R., Machesky, Laura M, Holyoake, Tessa L., Holyoake, Tessa L, Calaminus, Simon D.J., Steve P. Watson, Watson, Steve P, Guitart, Amelie, Machesky, Laura M., Simon D J Calaminus, Kranc, Kamil R, Watson, Steve, Laura M. Machesky, Holyoake, Tessa, Sinclair, Amy, Hannah Schachtner, Simon D. J. Calaminus, Laura M Machesky, Guitart, Amelie, V, Tessa L Holyoake, Kranc, Kamil, Kamil R. Kranc, Kamil R Kranc   +34 more
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

THE INSTABILITY OF RED BLOOD CELLS [PDF]

The Lancet, 1919
n ...
openaire   +2 more sources

Reversibility of red blood cell deformation [PDF]

Physical Review E, 2012
The ability of cells to undergo reversible shape changes is often crucial to their survival. For Red Blood Cells (RBCs), irreversible alteration of the cell shape and flexibility often causes anemia. Here we show theoretically that RBCs may react irreversibly to mechanical perturbations because of tensile stress in their cytoskeleton.
Zeitz, Maria, Sens, P.
openaire   +3 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Effects of aggregation on the blood flow velocity field measured by a μPIV based technique [PDF]

, 2009
This paper was presented at the 2nd Micro and Nano Flows Conference (MNF2009), which was held at Brunel University, West London, UK. The conference was organised by Brunel University and supported by the Institution of Mechanical Engineers, IPEM, the ...
2nd Micro and Nano Flows Conference (MNF2009), Balabani, S, Kaliviotis, E, Dusting, J   +3 more
core  

ASSOCIATION OF HUMAN NEUTROPHIL ANTIGENS WITH HAPLOTYPES IN SICKLE CELL ANEMIA

Hematology, Transfusion and Cell Therapy
Introduction: The SLC44A2 gene (rs2288094) encodes a choline-like membrane transporter expressed in various cells including blood cells. Genetic variants in this gene are associated with blood antigen polymorphisms, such as the human neutrophil antigens (
JO Rios, CC Lobo, S Azouzi, CR Bonini-Domingos   +3 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

The maturation of reticulocytes. I. Following introduction of reticulocytes into polycythemic and normocythemic animals [PDF]

, 1975
Investigations were conducted on the life-span of "stress" reticulocytes and the fate of the early denucleated large-sized reticulocytes in circulating blood.
Shimada, Atsuko
core   +1 more source