Results 81 to 90 of about 10,577,810 (295)

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

open access: yesMolecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu   +9 more
wiley   +1 more source

Safety and efficacy of voxelotor in adult patients with sickle cell disease

open access: yesBlood Red Cells & Iron
: On 25 September 2024, Pfizer announced the voluntary withdrawal of voxelotor because of an imbalance in vaso-occlusive crises (VOCs) and fatal events.
Friederike Poppenborg   +5 more
doaj   +1 more source

Endovascular Treatment of Aortic Aneurysms and Blood Transfusion. What do We Need?

open access: yesActa Médica Portuguesa, 2016
Introduction: Comparatively to open repair, endovascular aneurysm repair has reduced transfusion rates but there’s no recommendation about number of red blood cells units to be crossmatched preoperatively.
Rui Machado   +4 more
doaj   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

open access: yesFEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar   +4 more
wiley   +1 more source

Parameter-Reduced YOLOv8n with GhostConv and C3Ghost for Automated Blood Cell Detection

open access: yesBioengineering
Accurate detection of blood cells in microscopic images plays a crucial role in automated hematological analysis and clinical diagnosis. Herein, we proposed an improved YOLOv8n-based model for efficient and precise detection of red blood cells (RBCs ...
Jing Yang   +4 more
doaj   +1 more source

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

open access: yesFEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta   +7 more
wiley   +1 more source

Red blood cell survival in sickle cell disease: evaluating the determinants of interindividual heterogeneity

open access: yesBlood Red Cells & Iron
: Because donor red blood cell (RBC) survival varies significantly between patients with sickle cell disease (SCD), it is important to identify determinants of RBC survival to allow for improvement of transfusion therapy.
Lydian A. de Ligt   +11 more
doaj   +1 more source

The influence of age, sex and altitude on the morphometry of red blood cells in bovines [PDF]

open access: yes, 2013
Aim: This study was conducted on local bovine breed (black and white breed) in the east and the south of Algeria in order to reveal the influence of age, sex and altitude on the morphometry of red blood cells.
Mohamed Melizi   +2 more
core   +2 more sources

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

open access: yesFEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin   +12 more
wiley   +1 more source

Hemolysis and liver failure after acetaminophen ingestion in a patient with glutathione reductase deficiency

open access: yesBlood Red Cells & Iron
: We describe the case of a 47-year-old woman who developed severe hemolytic anemia, methemoglobinemia, acute liver injury, and acute kidney injury after acetaminophen ingestion.
John Schell   +4 more
doaj   +1 more source

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