Results 81 to 90 of about 2,648,431 (354)

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Red cell interactions with amyloid-β1–40 fibrils in a murine model

Neurobiology of Disease, 2005
Vascular amyloidosis in Alzheimer's disease (AD) results in the exposure of red blood cells to β-amyloid fibrils (Aβ). The potential in vivo ramifications of this exposure have been investigated by injecting Aβ1–40 alone or Aβ-bound mouse red blood cells
Luke B. Ravi, Suresh Poosala, Dongchoon Ahn, Francis J. Chrest, Edward L. Spangler, Rajadas Jayakumar, Enika Nagababu, Joy G. Mohanty, Mark Talan, Donald K. Ingram, Joseph M. Rifkind   +10 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Hemotrophic mycoplasmas induce programmed cell death in red blood cells [PDF]

, 2011
Hemotrophic mycoplasmas (HM) are uncultivable bacteria found on and in the red blood cells (RBCs). The main clinical sign of HM infections is the hemolytic anemia. However, anemia-inducing pathogenesis has not been totally clarified. In this work we used
Groebel, K, Ritzmann, Mathias, Hoelzle, Katharina, Kilchling, T, Mathias Ritzmann, Ritzmann, M, Felder, Kathrin M., Hoelzle, K, Ludwig E. Hoelzle, Schiele, D, Katharina Hoelzle, Heinritzi, K, Daniela Schiele, Kilchling, Tim, Kathrin M. Felder, Tim Kilchling, Karl Heinritzi, Felder, K M, Katrin Groebel, Heinritzi, Karl, Groebel, Katrin, Schiele, Daniela, Hoelzle, Ludwig E, Hoelzle, Ludwig E.   +23 more
core   +1 more source

Red blood cells in sports: Effects of exercise and training on oxygen supply by red blood cells

Frontiers in Physiology, 2013
During exercise the cardiovascular system has to warrant substrate supply to working muscle. The main function of red blood cells in exercise is the transport of O2 from the lungs to the tissues and the delivery of metabolically produced CO2 to the lungs
Heimo eMairbäurl
doaj   +1 more source

The adaptability of red blood cells [PDF]

Cardiovascular Diabetology, 2013
The most important function of red blood cells (RBCs) is the carrying of oxygen, but they are also involved in inflammatory processes and during coagulation. RBCs are extremely deformable and elastic, as they are exposed to shear forces as they travel through the vascular system.
openaire   +3 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Activation of human NK cells by Plasmodium-infected red blood cells.

, 2012
This chapter describes a protocol to assess activation of human NK cells following in vitro stimulation with malaria-infected red blood cells. Activation is assessed by flow cytometry, staining for cell surface expression of CD69 and accumulation of ...
Riley, Eleanor M, Horowitz, Amir, Amir Horowitz, Eleanor M. Riley   +3 more
core   +1 more source

Renal pericytes: regulators of medullary blood flow [PDF]

, 2012
Regulation of medullary blood flow (MBF) is essential in maintaining normal kidney function. Blood flow to the medulla is supplied by the descending vasa recta (DVR), which arise from the efferent arterioles of juxtamedullary glomeruli.
Peppiatt-Wildman, Claire M., Kennedy-Lydon, T M, Wildman, S S P, Peppiatt-Wildman, C M, Peppiatt‐Wildman, C. M., Kennedy‐Lydon, T. M., Wildman, Scott S.P., Kennedy-Lydon, T. M., Crawford, C., Crawford, C, Wildman, S. S. P.   +10 more
core   +1 more source

Mechanism of faster NO scavenging by older stored red blood cells

Redox Biology, 2014
The blood storage lesion involves morphological and biochemical changes of red blood cells (RBCs) that occur during storage. These include conversion of the biconcave disc morphology to a spherical one, decreased mean corpuscular hemoglobin concentration,
Chen Liu, Xiaohua Liu, John Janes, Ryan Stapley, Rakesh P. Patel, Mark T. Gladwin, Daniel B. Kim-Shapiro   +6 more
doaj   +1 more source