Metabolic pathways that correlate with post-transfusion circulation of stored murine red blood cells
Haematologica, 2016 Transfusion of red blood cells is a very common inpatient procedure, with more than 1 in 70 people in the USA receiving a red blood cell transfusion annually.
Karen de Wolski +7 more
doaj +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Increased activity of Piezo1 channel in red blood cells is associated with Alzheimer's disease-related dementia [PDF]
INTRODUCTION: Red blood cells (RBCs) are crucial for oxygen delivery to active tissues and endure significant mechanical forces in the microcirculatory bed.
Kanninen, Katja M. +18 more
core +1 more source
Plasmodium berghei-infection induces volume-regulated anion channel-like activity in human hepatoma cells [PDF]
, 2009 Parasite infection can lead to alterations in the permeability of host plasma membranes. Presented here is the first demonstration that this phenomenon occurs in Plasmodium‐infected liver cells.
Staines, Henry M. +11 more
core +1 more source
Laboratory and clinical management of leukocytospermia and hematospermia: a review
Therapeutic Advances in Reproductive Health, 2020 Leukocytospermia and hematospermia are defined as the presence of abnormally high white blood cell and red blood cell concentration in the semen, respectively. Numerous etiologies and various implications on fertility have been identified.
Kajal Khodamoradi +7 more
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Preliminary study of alterations in human red blood cells by irradiation with high energy photons [PDF]
, 2019 Introduction: Transfusion-associated graft-versus-host disease can be prevented by treating cellular blood products with gamma irradiation. A wide range of gamma irradiation dose levels are used in routine practice, but gamma irradiation dose of 25 Gy ...
Borraz, Javier +17 more
core +1 more source
The mechanisms underlying the impact of erythrocytes on coagulation and thrombus formation
Zhongguo shuxue zazhiRed blood cells (RBCs), as a key component determining the hemorheological properties, play a significant role in the dynamic process of thrombosis by regulating blood viscosity, shear stress distribution, and complex molecular mechanisms (including ...
MIN Haolin, LU Hua
doaj +1 more source
Aplikasi self-organizing mapping sebagai alat deteksi anemia pada citra sel darah merah
Jurnal Gizi Klinik Indonesia, 2019 Application of self-organizing mapping as anemia detection using an image of red blood cells Background: Anemia is a nutritional problem characterized by changes in blood cell size, especially in microcytic or macrocytic anemia.
Evrita Lusiana Utari +2 more
doaj +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source