Results 101 to 110 of about 2,648,431 (354)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Laboratory and clinical management of leukocytospermia and hematospermia: a review

Therapeutic Advances in Reproductive Health, 2020
Leukocytospermia and hematospermia are defined as the presence of abnormally high white blood cell and red blood cell concentration in the semen, respectively. Numerous etiologies and various implications on fertility have been identified.
Kajal Khodamoradi, Manish Kuchakulla, Manish Narasimman, Zahra Khosravizadeh, Aleena Ali, Nancy Brackett, Emad Ibrahim, Ranjith Ramasamy   +7 more
doaj   +1 more source

Combining Biomimetic Block Copolymer Worms with an Ice‐Inhibiting Polymer for the Solvent‐Free Cryopreservation of Red Blood Cells

Angewandte Chemie, 2016
The first fully synthetic polymer‐based approach for red‐blood‐cell cryopreservation without the need for any (toxic) organic solvents is reported. Highly hydroxylated block copolymer worms are shown to be a suitable replacement for hydroxyethyl starch ...
Daniel E. Mitchell, J. Lovett, S. Armes, M. Gibson   +3 more
semanticscholar   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

The mechanisms underlying the impact of erythrocytes on coagulation and thrombus formation

Zhongguo shuxue zazhi
Red blood cells (RBCs), as a key component determining the hemorheological properties, play a significant role in the dynamic process of thrombosis by regulating blood viscosity, shear stress distribution, and complex molecular mechanisms (including ...
MIN Haolin, LU Hua
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

ASSOCIATION OF HUMAN NEUTROPHIL ANTIGENS WITH HAPLOTYPES IN SICKLE CELL ANEMIA

Hematology, Transfusion and Cell Therapy
Introduction: The SLC44A2 gene (rs2288094) encodes a choline-like membrane transporter expressed in various cells including blood cells. Genetic variants in this gene are associated with blood antigen polymorphisms, such as the human neutrophil antigens (
JO Rios, CC Lobo, S Azouzi, CR Bonini-Domingos   +3 more
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Hemochromatosis alters the sensitivity of red blood cells to mechanical stress

, 2020
Background: Hemochromatosis (HH) is characterized by chronic iron accumulation, leading to deleterious effects to various organ systems. A common approach to managing iron load involves large-volume venesection.
Michael J. Simmonds, Richardson, KJ, Antony P. McNamee, McNamee, AP, Kieran J. Richardson, Simmonds, MJ   +5 more
core   +1 more source

Preliminary study of alterations in human red blood cells by irradiation with high energy photons [PDF]

, 2019
Introduction: Transfusion-associated graft-versus-host disease can be prevented by treating cellular blood products with gamma irradiation. A wide range of gamma irradiation dose levels are used in routine practice, but gamma irradiation dose of 25 Gy ...
Borraz, Javier, Bibiana Riquelme, Acosta, Andrea, Ivan Tac, Horacio Castellini, Castellini, Horacio V., Alejandro Chinelatto, Mariel E. Galassi, Estrada, Ezequiel, Tack, Ivan, Andrea Acosta, Di Tullio, Liliana, Galassi, Mariel Elisa, Javier Borraz, Ezequiel Estrada, Liliana Di Tullio, Riquelme, Bibiana Doris, Chinelatto, Alejandro   +17 more
core   +1 more source