Results 101 to 110 of about 10,577,810 (295)
FEBS Open Bio, EarlyView.The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley +1 more source
Safety and hematologic impact of high-dose
Blood Red Cells & Iron: Sickle cell disease (SCD) is characterized by oxidative stress, erythrocyte dehydration, and endothelial activation, promoting vaso-occlusion through the expression of adhesion molecules, including von Willebrand factor (VWF), and the presence of rigid
Junmei Chen +14 more
doaj +1 more source
FEBS Open Bio, EarlyView.Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill +6 more
wiley +1 more source
Heme-induced metabolic stress mediates ferroptosis response in sickle erythroblasts
Blood Red Cells & Iron: Sickle cell disease (SCD) is characterized by chronic hemolysis and excess free heme, which drive oxidative stress, inflammation, and progressive organ damage.
Caixia Xi +4 more
doaj +1 more source
In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols
FEBS Open Bio, EarlyView.Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton +6 more
wiley +1 more source
Reflections on the dual nature of iron in life
Blood Red Cells & Iron: Iron is the elemental hinge on which biological existence turns. Earth’s early oceans offered life a ready chemistry of electron exchange; in oxygenated worlds it became both the engine and the hazard.
Z. Ioav Cabantchik
doaj +1 more source
Production of hematopoietic cells from umbilical cord blood stem cells for transfusion purposes: Focus on ex vivo generation of red blood cells [PDF]
Scripta Medica, 2012 Cord blood contains a heterogeneous population of stem cells and progenitors and, in addition to transplantation these cells could be used also for ex vivo production of mature cells, as red blood cells (RBC).
Ivanović Zoran, Vlaski Marija
doaj
FEBS Open Bio, EarlyView.The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti +5 more
wiley +1 more source
Holographic cytometry assesses therapeutic effects in sickle cell disease
Blood Red Cells & Iron: Sickle cell disease (SCD) is a genetic blood disorder that causes red blood cells (RBCs) to become rigid and crescent-shaped when exposed to low oxygen tensions because of polymerization of variant hemoglobin S (HbS).
Robert E. Highland, III +7 more
doaj +1 more source
FEBS Open Bio, EarlyView.Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta +7 more
wiley +1 more source