Results 121 to 130 of about 2,648,431 (354)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Research progress on the role of red blood cells in infectious diseases

Zhongguo shuxue zazhi
As the most abundant cells in blood, red blood cells have been gradually found to not only transport oxygen and carbon dioxide, but also participate in immune regulation in many ways.
Ling XIAO, Li TIAN
doaj   +1 more source

P2X and P2Y receptor signaling in red blood cells

Frontiers in Molecular Biosciences, 2015
Purinergic signaling involves the activation of cell surface P1 and P2 receptors by extracellular nucleosides and nucleotides such as adenosine and adenosine triphosphate (ATP), respectively.
R. Sluyter
semanticscholar   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Mechanics of blood flow in capillaries

, 2009
This paper was presented at the 2nd Micro and Nano Flows Conference (MNF2009), which was held at Brunel University, West London, UK. The conference was organised by Brunel University and supported by the Institution of Mechanical Engineers, IPEM, the ...
2nd Micro and Nano Flows Conference (MNF2009), Secomb, TW   +1 more
core  

Destruction of Red Blood Cells. VII. Apparent Autosensitization to Dog Red Blood Cells.

Experimental Biology and Medicine, 1949
Summary and ConclusionsSeveral attempts were made to sensitize 4 dogs to their own red blood cells. Three dogs showed no definite evidence of autosensitization. Although 2 of these 3 dogs showed occasional marked fluctuation in mechanical fragility unaccompanied by other changes during these studies this was considered to be due to technical ...
P F, WAGLEY, W B, CASTLE
openaire   +2 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

The malaria secretome: from algorithms to essential function in blood stage infection [PDF]

, 2008
The malaria agent <i>Plasmodium falciparum</i> is predicted to export a "secretome" of several hundred proteins to remodel the host erythrocyte.
Kooij Taco, John Adams, Harrison Travis, uvik So Bhattacharjee, Andrew P. Waters, Andy Waters, Waters, A.P., Harrison, T., Travis Harrison, Balu, B., van Ooij Christiaan, Haldar Kasturi, Adamson, J., Liolios Konstantinos, Kooij, T.W.A., N Luisa Hiller, Konstantinos Liolios, Souvik Bhattacharjee, Chris J. Janse, Christiaan van Ooij, Haldar, K., Balu Bharath, Hiller N. Luisa, Christiaan van Ooij, N. Luisa Hiller, Janse, C.J., Pamela Tamez, Ramesar, J., Bharath Balu, Kasturi Haldar, Chris Janse, Waters Andy, Janse Chris, Tamez Pamela, van Ooij, C., Hiller, N.L., Chris J Janse, Jai Ramesar, Tamez, P., Bhattacharjee, S., Ramesar Jai, Liolios, K., Taco Kooij, Adams John, Bhattacharjee Souvik, Andrew P Waters   +45 more
core   +1 more source

GBT440 reverses sickling of sickled red blood cells under hypoxic conditions in vitro

Hematology Reports, 2018
Sickle cell disease is characterized by hemolytic anemia, vasoocclusion and early mortality. Polymerization of hemoglobin S followed by red blood cell sickling and subsequent vascular injury are key events in the pathogenesis of sickle cell disease ...
Kobina Dufu, Donna Oksenberg
doaj   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source