Results 121 to 130 of about 1,224,953 (315)

Destruction of Red Blood Cells. VII. Apparent Autosensitization to Dog Red Blood Cells.

Experimental Biology and Medicine, 1949
Summary and ConclusionsSeveral attempts were made to sensitize 4 dogs to their own red blood cells. Three dogs showed no definite evidence of autosensitization. Although 2 of these 3 dogs showed occasional marked fluctuation in mechanical fragility unaccompanied by other changes during these studies this was considered to be due to technical ...
P F, WAGLEY, W B, CASTLE
openaire   +2 more sources

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

Red cell transfusion triggers in critically ill patients:time for some new TRICCs? [PDF]

, 2010
Current evidence suggests that critically ill patients tolerate anaemia well and that blood transfusions may increase the risk of adverse outcomes. Dr Sakr and colleagues present a contradictory analysis of a surgical ICU cohort, finding an association ...
Walsh, Timothy S; id_orcid, Timothy S Walsh   +1 more
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

The malaria secretome: from algorithms to essential function in blood stage infection [PDF]

, 2008
The malaria agent <i>Plasmodium falciparum</i> is predicted to export a "secretome" of several hundred proteins to remodel the host erythrocyte.
Kooij Taco, John Adams, Harrison Travis, uvik So Bhattacharjee, Andrew P. Waters, Andy Waters, Waters, A.P., Harrison, T., Travis Harrison, Balu, B., van Ooij Christiaan, Haldar Kasturi, Adamson, J., Liolios Konstantinos, Kooij, T.W.A., N Luisa Hiller, Konstantinos Liolios, Souvik Bhattacharjee, Chris J. Janse, Christiaan van Ooij, Haldar, K., Balu Bharath, Hiller N. Luisa, Christiaan van Ooij, N. Luisa Hiller, Janse, C.J., Pamela Tamez, Ramesar, J., Bharath Balu, Kasturi Haldar, Chris Janse, Waters Andy, Janse Chris, Tamez Pamela, van Ooij, C., Hiller, N.L., Chris J Janse, Jai Ramesar, Tamez, P., Bhattacharjee, S., Ramesar Jai, Liolios, K., Taco Kooij, Adams John, Bhattacharjee Souvik, Andrew P Waters   +45 more
core   +1 more source

GBT440 reverses sickling of sickled red blood cells under hypoxic conditions in vitro

Hematology Reports, 2018
Sickle cell disease is characterized by hemolytic anemia, vasoocclusion and early mortality. Polymerization of hemoglobin S followed by red blood cell sickling and subsequent vascular injury are key events in the pathogenesis of sickle cell disease ...
Kobina Dufu, Donna Oksenberg
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Advances in Red Blood Cells Research

Cells
This Editorial ‘Advances in Red Blood Cell Research’ is the preface for the special issue with the same title which files 14 contributions listed in Table 1 [...]
Anna Bogdanova, Lars Kaestner
doaj   +1 more source

Fluorescence Exclusion: A Simple Method to Assess Projected Surface, Volume and Morphology of Red Blood Cells Stored in Blood Bank

Frontiers in Medicine, 2018
Red blood cells (RBC) ability to circulate is closely related to their surface area-to-volume ratio. A decrease in this ratio induces a decrease in RBC deformability that can lead to their retention and elimination in the spleen.
Camille Roussel, Camille Roussel, Camille Roussel, Camille Roussel, Camille Roussel, Sylvain Monnier, Michael Dussiot, Michael Dussiot, Elisabeth Farcy, Olivier Hermine, Olivier Hermine, Olivier Hermine, Olivier Hermine, Caroline Le Van Kim, Caroline Le Van Kim, Caroline Le Van Kim, Yves Colin, Yves Colin, Yves Colin, Matthieu Piel, Matthieu Piel, Pascal Amireault, Pascal Amireault, Pascal Amireault, Pascal Amireault, Pierre A. Buffet, Pierre A. Buffet, Pierre A. Buffet, Pierre A. Buffet, Pierre A. Buffet   +29 more
doaj   +1 more source