Results 41 to 50 of about 10,577,810 (295)

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Characterization of erythroblastic island and tissue macrophages using a novel CD169-tdTomato-Cre mouse model and scRNA-seq

Blood Red Cells & Iron
: Macrophages play diverse roles, including supporting erythropoiesis. CD169 is a specific marker for macrophages. However, recent studies showed that anti-CD169 staining detected nonmacrophages, raising the concern for using anti-CD169 antibody to ...
Donghao Liu, Huan Zhang, Qianqian Yang, Anqi Guo, Huizhi Zhao, Xinhua Guo, Karina Yazdanbakhsh, Xiuli An   +7 more
doaj   +1 more source

Red blood cell morphology [PDF]

International Journal of Laboratory Hematology, 2013
SummaryThe foundation of laboratory hematologic diagnosis is the complete blood count and review of the peripheral smear. In patients with anemia, the peripheral smear permits interpretation of diagnostically significant red blood cell (RBC) findings. These include assessment of RBC shape, size, color, inclusions, and arrangement.
openaire   +2 more sources

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Freeze-thaw lysates of P. falciparum-infected red blood cells induce differentiation of functionally competent regulatory T cells from memory T cells. [PDF]

, 2012
: In addition to naturally occurring regulatory T (nTreg) cells derived from the thymus, functionally competent Treg cells can be induced in vitro from peripheral blood lymphocytes in response to T-cell receptor stimulation with cytokine co-stimulation ...
Finney, OC, Walther, M, Riley, EM, Gray, AP, Lawrence, E, Njie, M   +5 more
core   +3 more sources

Erythroid-derived extracellular vesicles and interplay with soluble transferrin receptor in hereditary hemolytic anemias

Blood Red Cells & Iron
: In hereditary hemolytic anemia (HHA), soluble transferrin receptor (sTfR) reflects erythropoietic activity, whereas in iron deficiency anemia, it indicates iron-restricted hematopoiesis.
Geoffrey Z. L. Kuppens, Annelies van Vuren, Stéphanie van Straaten, Richard van Wijk, Arjen M. Punt, Chi Hau, Jesper B. Petersen, Daniel El Fassi, Rienk Nieuwland, Andreas Glenthøj, Eduard J. van Beers, Marije Bartels   +11 more
doaj   +1 more source

Red blood cells contain enzymatically active GPx4 whose abundance anticorrelates with hemolysis during blood bank storage

Redox Biology, 2021
The antioxidant function of the phospholipid hydroperoxide glutathione peroxidase (GPx4) is vital for the homeostasis of many cell types, from neoplastic cells to normal erythroid precursors.
Jeffrey M. Stolwijk, Jonathan A. Stefely, Mike T. Veling, Thomas J. van ‘t Erve, Brett A. Wagner, Thomas J. Raife, Garry R. Buettner   +6 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Fetal hemoglobin in bone marrow failure syndromes: comparative utility vs PNH clones and telomere length

Blood Red Cells & Iron
: Bone marrow failure syndromes (BMFS) are rare disorders characterized by impaired hematopoiesis, and distinguishing inherited BMFS (IBMFS) from acquired aplastic anemia (AA) is essential for management.
Victoria Heigh, Xi Zhang, Maymona G. Abdelmagid, Laura Ongie, Terra L. Lasho, Alejandro Ferrer, Anand Srinivasan, Mira A. Kohorst, Ahmad H. Al-Huniti, William J. Hogan, Naseema Gangat, Aref Al-Kali, Hassan B. Alkhateeb, Mithun V. Shah, Mehrdad Hefazi, Aasiya Matin, Yael Kusne, James Foran, Mrinal M. Patnaik, Abhishek A. Mangaonkar   +19 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source