Results 51 to 60 of about 596,834 (302)

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Red blood cell distribution width to platelet ratio in neonatal foals with sepsis

Journal of Veterinary Internal Medicine, 2023
Background Rapid and accurate markers to aid diagnosis of sepsis are needed in neonatal foals. The CBC variable red blood cell distribution width (RDW) to platelet ratio (RPR) is associated with inflammatory response and linked to poor outcomes of sepsis
Rebeca Scalco, Gabriela Novo deOliveira, Bruna daRosa Curcio, McCaide Wooten, K. Gary Magdesian, Stephanie Takako Hidai, Pranav Pandit, Monica Aleman   +7 more
doaj   +1 more source

Relation between red blood cell distribution width and acute kidney injury in patients with sepsis

Einstein (São Paulo), 2022
Objective The objective of the present study is to evaluate the association of red blood cell distribution width with acute kidney injury in sepsis. Methods This is a retrospective study of 849 critically ill patients with sepsis in intensive care ...
Marina Larissa Vettorello Ramires, Manoela Fidelis Batista Leite, Daniel Zu Yow Lo, Leonardo Bonilla da Silveira, Leonardo José Rolim Ferraz, Andreia Pardini, Araci Massami Sakashita, Andrea Tiemi Kondo, Guilherme Benfatti Olivato, Marcelino de Souza Durão Junior, Adelson Marçal Rodrigues, Daniela Mendes Chiloff, Danilo Candido de Almeida, Miguel Angelo Goes   +13 more
doaj   +1 more source

Accurate simulations of the interplay between process and statistical variability for nanoscale FinFET-based SRAM cell stability [PDF]

, 2014
In this paper we illustrate how by using advanced atomistic TCAD tools the interplay between long-range process variation and short-range statistical variability in FinFETs can be accurately modelled and simulated for the purposes of Design-Technology Co-
Asenov, A., Brown, A.R., Cheng, B., Millar, C., Wang, X.   +4 more
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Investigating the role of red cell and platelet distribution width-to-platelet ratios in diagnosing early-onset neonatal sepsis

Iraqi Journal of Hematology
BACKGROUND: Early and accurate diagnosis of early-onset neonatal sepsis (EONS) is vital in improving survival and outcome in affected neonates. To date, no single inflammatory biomarker has demonstrated both high sensitivity and specificity for the ...
Nabeeha Najatee Akram, Shahad Ali Ahmed Al-Baldawi, Essam Ahmed Abdullah, Shaymaa Khalid Abdulqader   +3 more
doaj   +1 more source

Red Cell Distribution Width: an Unacknowledged Predictor of Mortality and Length of Stay following Revision Arthroplasty [PDF]

, 2015
Introduction Red blood cell distribution width (RDW), a measure of variability in size of circulating erythrocytes, is routinely reported in complete blood cell analysis, and together with mean cell volume (MCV) has conventionally been used to ...
Alijanipour, MD, Pouya, Heller, MD, Snir, Kucukdurmaz, MD, Fatih, Parvizi, MD, FRCS, Javad, Rezapoor, MS, Maryam, Zmistowski, MD, Benjamin   +5 more
core   +1 more source

Logarithmic distributions prove that intrinsic learning is Hebbian

, 2017
In this paper, we present data for the lognormal distributions of spike rates, synaptic weights and intrinsic excitability (gain) for neurons in various brain areas, such as auditory or visual cortex, hippocampus, cerebellum, striatum, midbrain nuclei ...
Scheler, Gabriele
core   +2 more sources

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source