Results 101 to 110 of about 4,581,457 (304)

A Study on the Impact of Blue Light and Its Brightness on Long-Term Memory

open access: yesApplied Sciences
The purpose of this study is to evaluate the effect of blue light and its brightness on long-term memory. Blue light was tested under four distinct illuminance conditions ranging from 400 to 1000 lux, and the results were compared with those of red light
Jin-Ho Kim   +3 more
doaj   +1 more source

GRB Afterglows from Anisotropic Jets

open access: yes, 2000
Some progenitor models of gamma-ray bursts (GRBs) (e.g., collapsars) may produce anisotropic jets in which the energy per unit solid angle is a power-law function of the angle ($\propto\theta^{-k}$).
Holland S.   +5 more
core   +4 more sources

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

open access: yesMolecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu   +12 more
wiley   +1 more source

Comprehensive omics‐based classification system in adult patients with B‐cell acute lymphoblastic leukemia

open access: yesMolecular Oncology, EarlyView.
The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song   +11 more
wiley   +1 more source

Molecular imaging predicts trastuzumab‐deruxtecan (T‐DXd) response in head and neck cancer xenograft models

open access: yesMolecular Oncology, EarlyView.
Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed   +8 more
wiley   +1 more source

Host galaxy colour gradients and accretion disc obscuration in AEGIS z~1 X-ray-selected active galactic nuclei

open access: yes, 2010
We describe the effect of AGN light on host galaxy optical and UV-optical colours, as determined from X-ray-selected AGN host galaxies at z~1, and compare the AGN host galaxy colours to those of a control sample matched to the AGN sample in both redshift
A. L. Coil   +102 more
core   +1 more source

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

open access: yesMolecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp   +13 more
wiley   +1 more source

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

Optical Probe of Quantum Shot Noise Reduction at a Single-Atom Contact

open access: yes, 2010
Visible and infra-red light emitted at a Ag-Ag(111) junction has been investigated from tunneling to single atom contact conditions with a scanning tunneling microscope. The light intensity varies in a highly nonlinear fashion with the conductance of the
G. B. Lesovik   +5 more
core   +1 more source

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