Results 111 to 120 of about 4,713,444 (302)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Mid-infrared spectroscopy of CAI and AOA from the Allende CV3.2 chondrite [PDF]

, 2005
Mid-infrared spectra of bulk CAI from the CV3.2 chondrite Allende are presented and compared with astronomical spectra of cometary dust, zodiacal light,the circumstellar disk of beta Pictoris and dust around the red supergiant PR ...
Bland, P. A., Cressey, G., Grady, M. M., Koehler, M., Menzies, O. N., Morlok, A.   +5 more
core  

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Inbreeding Affects on Beetle Clustering [PDF]

, 2018
The Red Flour Beetle (Tribolium castaneum; Coleoptera: Tenebrionidae) is a common pest in many grain mills (Baldwin and Fasulo 2010) and found wherever grains or other dried foods are stored (Schröder 2008).
Key, Morgan, Marshall, Jeremy
core  

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Effects of monochromatic red and blue light on photosynthetic efficiency and nutritional quality in Chinese kale microgreens

Frontiers in Plant Science
Microgreens, a type of rapidly grown and consumed vegetable, are rich in secondary metabolites. Chlorophyll serves as a crucial component contributing to their visual quality and is also recognized as a key nutritional constituent in Chinese kale ...
Honghua Yu, Xiaodong Chen, Zhanfeng Yang, Jiaxuan Chen, Chenhao Guan, Hao Weng, Rongfang Guo, Rongfang Guo   +7 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Photoresponsive nanocapsulation of cobra neurotoxin and enhancement of its central analgesic effects under red light

International Journal of Nanomedicine, 2017
Qian Yang, Chuang Zhao, Jun Zhao, Yong Ye Department of Pharmaceutical Engineering, School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou, People’s Republic of China Abstract: Cobra neurotoxin (CNT), a ...
Yang Q, Zhao C, Zhao J, Ye Y
doaj  

Short-Term Postharvest LED Irradiation Modulates Phytochemical and Quality Dynamics of Strawberries

Turkish Journal of Agriculture: Food Science and Technology
This study investigated the potential of a short-term light-emitting diode (LED) irradiation applied immediately postharvest to enhance the phytochemical content and quality attributes of 'Festival' strawberries.
Özge Horzum
doaj   +1 more source