Results 51 to 60 of about 623,543 (256)

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Patterns of uncertainty in life-history and extinction risk for Arctic vertebrates

Arctic Science, 2018
Conserving Arctic wildlife will be challenging given the ongoing environmental changes in the region. In addition, there is a lack of fundamental biological information for many Arctic species, including a dearth of knowledge surrounding conservation ...
Cody J. Dey, David J. Yurkowski, Richard Schuster, David S. Shiffman, Sarah Joy Bittick   +4 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Conservation of Rare and Endangered Algae in Mongolia

Mongolian Journal of Biological Sciences, 2021
We analyzed the distribution area of the threatened algal species concerning Mongolia’s nationally and internationally protected areas, using Geographic Information Systems analysis.
Bukhchuluun Tsegmid
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Developing a threat risk register based on the IUCN threat hierarchy for five tropical Important Plant Areas in Guinea [PDF]

PeerJ
A pilot study to develop a threat risk register for Tropical Important Plant Areas in Guinea using the IUCN threat hierarchy is outlined. Guinea lost 92% of its total original forest before the end of the 20th Century.
Charlotte Couch, Faya Julien Simbiano, Mamadou Diawara, EdgarFrançois Loua, Léonce Mamy, Martin Cheek, Sékou Magassouba   +6 more
doaj   +2 more sources

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Seeing Red: Inside the Science and Politics of the IUCN Red List

Conservation & Society, 2012
The Red List of Threatened Species™ (hereafter Red List) is the International Union for the Conservation of Nature′s most recognisable product. The Red List categorises the conservation status of species on a global scale using ′the most objective ...
Lisa M Campbell
doaj   +1 more source

Updated Red List of bryophytes of Slovenia [PDF]

Hacquetia, 2016
Abstract Based on floristic data and applied taxonomy there are currently 813 species and subspecies in Slovenia – 638 mosses, 173 liverworts and 2 hornworts. Based on the IUCN 3.1 criteria, which we applied to bryophytes following Hallingbäck et al. (1998), there are 164 species (20.17%) listed under threatened categories, of which 121 (
openaire   +2 more sources